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Relationship between Antibody-Positive Rate against Plasmodium vivax Circumsporozoite Protein and Incidence of Malaria.

Lee HW, Kang YJ, Cho SH, Na BK, Pak JH, Nam HW, Park YK, Sohn Y, Kim TS - Korean J. Parasitol. (2015)

Bottom Line: The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively).The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years.The positive rates of CSP-ELISA were closely related to the APIs in the study areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, FL 32610, USA.

ABSTRACT
The relationship between anti- Plasmodium vivax circumsporozoite protein (CSP) antibody levels and the prevalence of malaria in epidemic areas of South Korea was evaluated. Blood samples were collected from inhabitants of Gimpo-si (city), Paju-si, and Yeoncheon-gun (county) in Gyeonggi-do (province), as well as Cheorwon-gun in Gangwon-do from November to December 2004. Microscopic examinations were used to identify malaria parasites. ELISA was used to quantitate anti-circumsporozoite protein (CSP) antibodies against P. vivax. A total of 1,774 blood samples were collected. The overall CSP-ELISA-positive rate was 7.7% (n=139). The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively). The positive rate in Gimpo (10.4%, 44/425) was the highest identified by CSP-ELISA. The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years. The positive rates of CSP-ELISA were closely related to the APIs in the study areas. These results suggest that seroepidemiological studies based on CSP may be helpful in estimating the malaria prevalence in certain areas. In addition, this assay can be used to establish and evaluate malaria control and eradication programs in affected areas.

No MeSH data available.


Related in: MedlinePlus

The number of malaria patients from 1993-2013 in the study areas. ●, Gimpo-si; ■, Paju-si; ▲, Yeoncheon-gun; ▼, Cheorwon-gun.
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f2-kjp-53-2-169: The number of malaria patients from 1993-2013 in the study areas. ●, Gimpo-si; ■, Paju-si; ▲, Yeoncheon-gun; ▼, Cheorwon-gun.

Mentions: The study locations are shown on the map in Fig. 1. All areas are near the DMZ, a known high-risk area for malaria. Blood samples were collected from participants residing in 23 villages in 3 cities (Gimpo, Paju, and Yeoncheon) located in Gyeonggi Province and from 6 villages in Cheorwon in Gangwon Province, South Korea. The total number of inhabitants in the study areas in 2004 was 92,246; thus, 1.92% of the whole population was sampled. In Paju, 1 malaria case was reported in 1993, and subsequently, 3,264 patients were reported up to 2013. In Gimpo, 1 patient was reported in 1995, and subsequently, 1,142 patients were reported up to 2013. In Yeoncheon, 2 patients were reported in 1995, and subsequently, 1,935 patients were reported up to 2013. In Cheorwon, 9 patients were reported in 1997, and subsequently, 1,388 patients were reported up to 2013. As shown in Fig. 2, the incidences of malaria patients reached its lowest levels in 2004, and then increased thereafter once a blood collection program had been initiated. The highest number of patients was reported in 2001 at 835 cases; however, only 90 cases were reported in the study areas (Fig. 2) (KCDC, personal communication).


Relationship between Antibody-Positive Rate against Plasmodium vivax Circumsporozoite Protein and Incidence of Malaria.

Lee HW, Kang YJ, Cho SH, Na BK, Pak JH, Nam HW, Park YK, Sohn Y, Kim TS - Korean J. Parasitol. (2015)

The number of malaria patients from 1993-2013 in the study areas. ●, Gimpo-si; ■, Paju-si; ▲, Yeoncheon-gun; ▼, Cheorwon-gun.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4416367&req=5

f2-kjp-53-2-169: The number of malaria patients from 1993-2013 in the study areas. ●, Gimpo-si; ■, Paju-si; ▲, Yeoncheon-gun; ▼, Cheorwon-gun.
Mentions: The study locations are shown on the map in Fig. 1. All areas are near the DMZ, a known high-risk area for malaria. Blood samples were collected from participants residing in 23 villages in 3 cities (Gimpo, Paju, and Yeoncheon) located in Gyeonggi Province and from 6 villages in Cheorwon in Gangwon Province, South Korea. The total number of inhabitants in the study areas in 2004 was 92,246; thus, 1.92% of the whole population was sampled. In Paju, 1 malaria case was reported in 1993, and subsequently, 3,264 patients were reported up to 2013. In Gimpo, 1 patient was reported in 1995, and subsequently, 1,142 patients were reported up to 2013. In Yeoncheon, 2 patients were reported in 1995, and subsequently, 1,935 patients were reported up to 2013. In Cheorwon, 9 patients were reported in 1997, and subsequently, 1,388 patients were reported up to 2013. As shown in Fig. 2, the incidences of malaria patients reached its lowest levels in 2004, and then increased thereafter once a blood collection program had been initiated. The highest number of patients was reported in 2001 at 835 cases; however, only 90 cases were reported in the study areas (Fig. 2) (KCDC, personal communication).

Bottom Line: The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively).The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years.The positive rates of CSP-ELISA were closely related to the APIs in the study areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, FL 32610, USA.

ABSTRACT
The relationship between anti- Plasmodium vivax circumsporozoite protein (CSP) antibody levels and the prevalence of malaria in epidemic areas of South Korea was evaluated. Blood samples were collected from inhabitants of Gimpo-si (city), Paju-si, and Yeoncheon-gun (county) in Gyeonggi-do (province), as well as Cheorwon-gun in Gangwon-do from November to December 2004. Microscopic examinations were used to identify malaria parasites. ELISA was used to quantitate anti-circumsporozoite protein (CSP) antibodies against P. vivax. A total of 1,774 blood samples were collected. The overall CSP-ELISA-positive rate was 7.7% (n=139). The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively). The positive rate in Gimpo (10.4%, 44/425) was the highest identified by CSP-ELISA. The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years. The positive rates of CSP-ELISA were closely related to the APIs in the study areas. These results suggest that seroepidemiological studies based on CSP may be helpful in estimating the malaria prevalence in certain areas. In addition, this assay can be used to establish and evaluate malaria control and eradication programs in affected areas.

No MeSH data available.


Related in: MedlinePlus