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Seroepidemiology of varicella-zoster virus in Korean adolescents and adults using fluorescent antibody to membrane antigen test.

Han SB, Kang KR, Huh DH, Lee HC, Kim JH, Kang JH, Ma SH - Epidemiol. Infect. (2014)

Bottom Line: Residual serum samples were collected from 1196 healthy adults and adolescents aged ⩾10 years between November 2012 and March 2013.The seroprevalences of VZV were compared between six age groups: 10-19, 20-29, 30-39, 40-49, 50-59, and ⩾60 years.Thus, strategies to increase protective immunity against VZV in teenagers are necessary.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics,College of Medicine,The Catholic University of Korea,Seoul,Republic of Korea.

ABSTRACT
We conducted a cross-sectional seroepidemiological study in 2012-2013 to determine the seroprevalence of varicella-zoster virus (VZV) in adolescents and adults living in Korea, where varicella vaccination has been recommended universally at age 12-15 months since 2005. Residual serum samples were collected from 1196 healthy adults and adolescents aged ⩾10 years between November 2012 and March 2013. The fluorescent antibody to membrane antigen (FAMA) test and enzyme-linked immunosorbent assay (ELISA) were performed to determine the seroprevalence of VZV. The seroprevalences of VZV were compared between six age groups: 10-19, 20-29, 30-39, 40-49, 50-59, and ⩾60 years. The seroprevalence of VZV in the entire study cohort was 99·1% according to the FAMA test and 93·1% as determined by ELISA. The seroprevalences of the six age groups were as follows: 96·0%, 99·5%, 99·5%, 99·5%, 100%, and 100%, respectively, by the FAMA test, and 83·3%, 93·0%, 93·0%, 97·5%, 94·5%, and 97·5%, respectively, by ELISA. Seroprevalence increased significantly with age (P < 0·001); moreover, the seroprevalence in subjects aged 10-19 years was significantly lower than in other age groups (P < 0·001), as measured by both the FAMA test and ELISA. Thus, strategies to increase protective immunity against VZV in teenagers are necessary.

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Proportion of cases according to the fluorescent antibody to membrane antigen titres in each age group.
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fig03: Proportion of cases according to the fluorescent antibody to membrane antigen titres in each age group.

Mentions: Eleven (0·9%) of the 1196 subjects were VZV-negative and 1185 (99·1%) were positive according to the FAMA test (Table 2). Of the subjects who were positive on the FAMA test, only four (0·3%) subjects showed weakly positive results; the remaining 1181 (98·8%) subjects had strongly positive titres of ⩾1:16 (Table 2). The seroprevalences of groups 1–6 were 96·0% (190/198), 99·5% (198/199), 99·5% (199/200), 99·5% (199/200), 100·0% (199/199) and 100·0% (200/200), respectively (Fig. 2). The seroprevalence of VZV tended to increase with age (P < 0·001), and group 1 (10–19 years) had a significantly lower seroprevalence compared to the older age groups (P < 0·001). The proportion of strongly positive subjects also increased significantly with age (P < 0·001), and all of the subjects in group 6 (⩾60 years) had strongly positive results (Fig. 3).Fig. 2.


Seroepidemiology of varicella-zoster virus in Korean adolescents and adults using fluorescent antibody to membrane antigen test.

Han SB, Kang KR, Huh DH, Lee HC, Kim JH, Kang JH, Ma SH - Epidemiol. Infect. (2014)

Proportion of cases according to the fluorescent antibody to membrane antigen titres in each age group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4416359&req=5

fig03: Proportion of cases according to the fluorescent antibody to membrane antigen titres in each age group.
Mentions: Eleven (0·9%) of the 1196 subjects were VZV-negative and 1185 (99·1%) were positive according to the FAMA test (Table 2). Of the subjects who were positive on the FAMA test, only four (0·3%) subjects showed weakly positive results; the remaining 1181 (98·8%) subjects had strongly positive titres of ⩾1:16 (Table 2). The seroprevalences of groups 1–6 were 96·0% (190/198), 99·5% (198/199), 99·5% (199/200), 99·5% (199/200), 100·0% (199/199) and 100·0% (200/200), respectively (Fig. 2). The seroprevalence of VZV tended to increase with age (P < 0·001), and group 1 (10–19 years) had a significantly lower seroprevalence compared to the older age groups (P < 0·001). The proportion of strongly positive subjects also increased significantly with age (P < 0·001), and all of the subjects in group 6 (⩾60 years) had strongly positive results (Fig. 3).Fig. 2.

Bottom Line: Residual serum samples were collected from 1196 healthy adults and adolescents aged ⩾10 years between November 2012 and March 2013.The seroprevalences of VZV were compared between six age groups: 10-19, 20-29, 30-39, 40-49, 50-59, and ⩾60 years.Thus, strategies to increase protective immunity against VZV in teenagers are necessary.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics,College of Medicine,The Catholic University of Korea,Seoul,Republic of Korea.

ABSTRACT
We conducted a cross-sectional seroepidemiological study in 2012-2013 to determine the seroprevalence of varicella-zoster virus (VZV) in adolescents and adults living in Korea, where varicella vaccination has been recommended universally at age 12-15 months since 2005. Residual serum samples were collected from 1196 healthy adults and adolescents aged ⩾10 years between November 2012 and March 2013. The fluorescent antibody to membrane antigen (FAMA) test and enzyme-linked immunosorbent assay (ELISA) were performed to determine the seroprevalence of VZV. The seroprevalences of VZV were compared between six age groups: 10-19, 20-29, 30-39, 40-49, 50-59, and ⩾60 years. The seroprevalence of VZV in the entire study cohort was 99·1% according to the FAMA test and 93·1% as determined by ELISA. The seroprevalences of the six age groups were as follows: 96·0%, 99·5%, 99·5%, 99·5%, 100%, and 100%, respectively, by the FAMA test, and 83·3%, 93·0%, 93·0%, 97·5%, 94·5%, and 97·5%, respectively, by ELISA. Seroprevalence increased significantly with age (P < 0·001); moreover, the seroprevalence in subjects aged 10-19 years was significantly lower than in other age groups (P < 0·001), as measured by both the FAMA test and ELISA. Thus, strategies to increase protective immunity against VZV in teenagers are necessary.

Show MeSH
Related in: MedlinePlus