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NeuroPep: a comprehensive resource of neuropeptides.

Wang Y, Wang M, Yin S, Jang R, Wang J, Xue Z, Xu T - Database (Oxford) (2015)

Bottom Line: Information derived from these peptide sequences such as amino acid compositions, isoelectric points, molecular weight and other physicochemical properties of peptides are also provided.A quick search feature allows users to search the database with keywords such as sequence, name, family, etc., and an advanced search page helps users to combine queries with logical operators like AND/OR.In addition, user-friendly web tools like browsing, sequence alignment and mapping are also integrated into the NeuroPep database.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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(A) The amino acid composition distribution of neuropeptides in NeuroPep database. (B) The amino acid length distribution of neuropeptides in NeuroPep database.
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bav038-F3: (A) The amino acid composition distribution of neuropeptides in NeuroPep database. (B) The amino acid length distribution of neuropeptides in NeuroPep database.

Mentions: The amino acid composition and length distribution of neuropeptides of the current database are shown in Figure 3A and B, respectively. It is observed that residues like Leu, Ala, Ser, Glu and Gly are more abundant while residues like Trp, Cys, Met, His and Tyr are the least abundant. We have also computed separately the amino acid composition of invertebrate and vertebrate neuropeptides in the NeuroPep database. It is found that the Phe abundance in invertebrate neuropeptides is 2.6 times of that in vertebrate neuropeptides, while the Lys abundance in vertebrate neuropeptides is 3 times of that in invertebrate neuropeptides (Supplementary Figure S1). As shown in Figure 3B, the length of the majority of the neuropeptides (79%) is <30. There are 18 entries in the database with the shortest length of three-amino-acids long. A small portion (6%) of sequences are >100 amino acids in length, most of which (341/346) are annotated as ‘CHAIN’ in the feature line of UniProt.Figure 3.


NeuroPep: a comprehensive resource of neuropeptides.

Wang Y, Wang M, Yin S, Jang R, Wang J, Xue Z, Xu T - Database (Oxford) (2015)

(A) The amino acid composition distribution of neuropeptides in NeuroPep database. (B) The amino acid length distribution of neuropeptides in NeuroPep database.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414954&req=5

bav038-F3: (A) The amino acid composition distribution of neuropeptides in NeuroPep database. (B) The amino acid length distribution of neuropeptides in NeuroPep database.
Mentions: The amino acid composition and length distribution of neuropeptides of the current database are shown in Figure 3A and B, respectively. It is observed that residues like Leu, Ala, Ser, Glu and Gly are more abundant while residues like Trp, Cys, Met, His and Tyr are the least abundant. We have also computed separately the amino acid composition of invertebrate and vertebrate neuropeptides in the NeuroPep database. It is found that the Phe abundance in invertebrate neuropeptides is 2.6 times of that in vertebrate neuropeptides, while the Lys abundance in vertebrate neuropeptides is 3 times of that in invertebrate neuropeptides (Supplementary Figure S1). As shown in Figure 3B, the length of the majority of the neuropeptides (79%) is <30. There are 18 entries in the database with the shortest length of three-amino-acids long. A small portion (6%) of sequences are >100 amino acids in length, most of which (341/346) are annotated as ‘CHAIN’ in the feature line of UniProt.Figure 3.

Bottom Line: Information derived from these peptide sequences such as amino acid compositions, isoelectric points, molecular weight and other physicochemical properties of peptides are also provided.A quick search feature allows users to search the database with keywords such as sequence, name, family, etc., and an advanced search page helps users to combine queries with logical operators like AND/OR.In addition, user-friendly web tools like browsing, sequence alignment and mapping are also integrated into the NeuroPep database.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, School of Software Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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Related in: MedlinePlus