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Role of Soluble ST2 as a Prognostic Marker in Patients with Acute Heart Failure and Renal Insufficiency.

Kim MS, Jeong TD, Han SB, Min WK, Kim JJ - J. Korean Med. Sci. (2015)

Bottom Line: BNP was sampled at the same time and compared to sST2.During 3 month follow-up, 9 (13.6%) died and 16 (24.2%) were readmitted due to HF aggravation.On multivariate analysis, sST2 at discharge was independently associated with death or HF readmission during 3 months after discharge (hazard ratio, 1.038; 95% confidence interval, 1.011-1.066, P = 0.006).In conclusion, sST2 is not affected by renal function compared with BNP in acute HF patients.

View Article: PubMed Central - PubMed

Affiliation: Asan Medical Center Heart Institute, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.

ABSTRACT
This study sought to assess the relationship between serum concentrations of the soluble ST2 (sST2) and B-type natriuretic peptide (BNP) and investigate the role of sST2 as a prognosticator in patients hospitalized with acute heart failure (HF) and renal insufficiency. sST2 was measured at admission and discharge in 66 patients hospitalized with acute decompensated HF and renal insufficiency (estimated glomerular filtration rate [eGFR] < 90 mL/min/1.73 m(2)) using a high sensitivity immunoassay. BNP was sampled at the same time and compared to sST2. Demographical, biochemical, and echocardiographic data were also obtained during hospitalization.There were positive correlations between sST2 and BNP levels at admission (r = 0.330, P = 0.007) and at discharge (r = 0.320, P = 0.009) in overall patients. However, there was no correlation between them at each timepoint in patients with severe renal insufficiency (eGFR < 30 mL/min/1.73 m(2), n = 17). sST2 level was not changed with the degree of renal function, even though BNP level was much higher in patients with severe renal insufficiency. During 3 month follow-up, 9 (13.6%) died and 16 (24.2%) were readmitted due to HF aggravation.On multivariate analysis, sST2 at discharge was independently associated with death or HF readmission during 3 months after discharge (hazard ratio, 1.038; 95% confidence interval, 1.011-1.066, P = 0.006). In conclusion, sST2 is not affected by renal function compared with BNP in acute HF patients. The measurement of predischarge sST2 can be helpful in predicting short-term outcomes in acute decompensated HF patients with renal insufficiency.

No MeSH data available.


Related in: MedlinePlus

Correlations between sST2 and BNP levels. The correlations between sST2 and BNP levels at admission (A) and at discharge (B) in total patients (n = 66). The correlation between sST2 and BNP levels at admission (C) and at discharge (D) in acute HF patients with mild to moderate renal insufficiency (n = 49). The correlation between sST2 and BNP levels at admission (E) and at discharge (F) in acute HF patients with severe renal insufficiency (n = 17).
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Figure 2: Correlations between sST2 and BNP levels. The correlations between sST2 and BNP levels at admission (A) and at discharge (B) in total patients (n = 66). The correlation between sST2 and BNP levels at admission (C) and at discharge (D) in acute HF patients with mild to moderate renal insufficiency (n = 49). The correlation between sST2 and BNP levels at admission (E) and at discharge (F) in acute HF patients with severe renal insufficiency (n = 17).

Mentions: There were mild correlations between sST2 and BNP at admission (r=0.330, P=0.007) and at discharge (r=0.320, P=0.009) in total patients (Fig. 2). In addition, there was mild correlation between them in patients with mild to moderate renal insufficiency (eGFR in 89-30 mL/min/1.73 m2, n=49: r=0.390, P= 0.006 for admission: r=0.367, P=0.029 for discharge). However, there was no correlation between them at each timepoint in patients with severe renal insufficiency (eGFR<30 mL/min/1.73 m2, n=17).


Role of Soluble ST2 as a Prognostic Marker in Patients with Acute Heart Failure and Renal Insufficiency.

Kim MS, Jeong TD, Han SB, Min WK, Kim JJ - J. Korean Med. Sci. (2015)

Correlations between sST2 and BNP levels. The correlations between sST2 and BNP levels at admission (A) and at discharge (B) in total patients (n = 66). The correlation between sST2 and BNP levels at admission (C) and at discharge (D) in acute HF patients with mild to moderate renal insufficiency (n = 49). The correlation between sST2 and BNP levels at admission (E) and at discharge (F) in acute HF patients with severe renal insufficiency (n = 17).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414640&req=5

Figure 2: Correlations between sST2 and BNP levels. The correlations between sST2 and BNP levels at admission (A) and at discharge (B) in total patients (n = 66). The correlation between sST2 and BNP levels at admission (C) and at discharge (D) in acute HF patients with mild to moderate renal insufficiency (n = 49). The correlation between sST2 and BNP levels at admission (E) and at discharge (F) in acute HF patients with severe renal insufficiency (n = 17).
Mentions: There were mild correlations between sST2 and BNP at admission (r=0.330, P=0.007) and at discharge (r=0.320, P=0.009) in total patients (Fig. 2). In addition, there was mild correlation between them in patients with mild to moderate renal insufficiency (eGFR in 89-30 mL/min/1.73 m2, n=49: r=0.390, P= 0.006 for admission: r=0.367, P=0.029 for discharge). However, there was no correlation between them at each timepoint in patients with severe renal insufficiency (eGFR<30 mL/min/1.73 m2, n=17).

Bottom Line: BNP was sampled at the same time and compared to sST2.During 3 month follow-up, 9 (13.6%) died and 16 (24.2%) were readmitted due to HF aggravation.On multivariate analysis, sST2 at discharge was independently associated with death or HF readmission during 3 months after discharge (hazard ratio, 1.038; 95% confidence interval, 1.011-1.066, P = 0.006).In conclusion, sST2 is not affected by renal function compared with BNP in acute HF patients.

View Article: PubMed Central - PubMed

Affiliation: Asan Medical Center Heart Institute, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.

ABSTRACT
This study sought to assess the relationship between serum concentrations of the soluble ST2 (sST2) and B-type natriuretic peptide (BNP) and investigate the role of sST2 as a prognosticator in patients hospitalized with acute heart failure (HF) and renal insufficiency. sST2 was measured at admission and discharge in 66 patients hospitalized with acute decompensated HF and renal insufficiency (estimated glomerular filtration rate [eGFR] < 90 mL/min/1.73 m(2)) using a high sensitivity immunoassay. BNP was sampled at the same time and compared to sST2. Demographical, biochemical, and echocardiographic data were also obtained during hospitalization.There were positive correlations between sST2 and BNP levels at admission (r = 0.330, P = 0.007) and at discharge (r = 0.320, P = 0.009) in overall patients. However, there was no correlation between them at each timepoint in patients with severe renal insufficiency (eGFR < 30 mL/min/1.73 m(2), n = 17). sST2 level was not changed with the degree of renal function, even though BNP level was much higher in patients with severe renal insufficiency. During 3 month follow-up, 9 (13.6%) died and 16 (24.2%) were readmitted due to HF aggravation.On multivariate analysis, sST2 at discharge was independently associated with death or HF readmission during 3 months after discharge (hazard ratio, 1.038; 95% confidence interval, 1.011-1.066, P = 0.006). In conclusion, sST2 is not affected by renal function compared with BNP in acute HF patients. The measurement of predischarge sST2 can be helpful in predicting short-term outcomes in acute decompensated HF patients with renal insufficiency.

No MeSH data available.


Related in: MedlinePlus