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Asthma, Airway Symptoms and Rhinitis in Office Workers in Malaysia: Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust.

Lim FL, Hashim Z, Than LT, Md Said S, Hisham Hashim J, Norbäck D - PLoS ONE (2015)

Bottom Line: Der f 1 level in dust was associated with daytime breathlessness (p= 0.033) especially among those with HDM allergy.In conclusion, HDM and cat allergies were common and independently associated with asthma, airway symptoms and rhinitis.Der f 1 allergen can be a risk factor for daytime breathlessness.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia.

ABSTRACT
A prevalence study was conducted among office workers in Malaysia (N= 695). The aim of this study was to examine associations between asthma, airway symptoms, rhinitis and house dust mites (HDM) and cat allergy and HDM levels in office dust. Medical data was collected by a questionnaire. Skin prick tests were performed for HDM allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) and cat allergen Felis domesticus. Indoor temperature and relative air humidity (RH) were measured in the offices and vacuumed dust samples were analyzed for HDM allergens. The prevalence of D. pteronyssinus, D. farinae and cat allergy were 50.3%, 49.0% and 25.5% respectively. Totally 9.6% had doctor-diagnosed asthma, 15.5% had current wheeze and 53.0% had current rhinitis. The Der p 1 (from D. pteronyssinus) and Der f 1 (from D. farinae) allergens levels in dust were 556 ng/g and 658 ng/g respectively. Statistical analysis was conducted by multilevel logistic regression, adjusting for age, gender, current smoking, HDM or cat allergy, home dampness and recent indoor painting at home. Office workers with HDM allergy had more wheeze (p= 0.035), any airway symptoms (p= 0.032), doctor-diagnosed asthma (p= 0.005), current asthma (p= 0.007), current rhinitis (p= 0.021) and rhinoconjuctivitis (p< 0.001). Cat allergy was associated with wheeze (p= 0.021), wheeze when not having a cold (p= 0.033), any airway symptoms (p= 0.034), doctor-diagnosed asthma (p= 0.010), current asthma (p= 0.020) and nasal allergy medication (p= 0.042). Der f 1 level in dust was associated with daytime breathlessness (p= 0.033) especially among those with HDM allergy. Der f 1 levels were correlated with indoor temperature (p< 0.001) and inversely correlated with RH (p< 0.001). In conclusion, HDM and cat allergies were common and independently associated with asthma, airway symptoms and rhinitis. Der f 1 allergen can be a risk factor for daytime breathlessness.

No MeSH data available.


Related in: MedlinePlus

Venn diagram for the distribution of subjects with a positive skin prick test to D. pteronyssinus, D. farinae and Felis domesticus in the group with skin prick test (n = 463).
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pone.0124905.g001: Venn diagram for the distribution of subjects with a positive skin prick test to D. pteronyssinus, D. farinae and Felis domesticus in the group with skin prick test (n = 463).

Mentions: We compared prevalence of asthma, rhinitis and eczema among participants and non-participants groups in the questionnaire study, the skin prick test, and the environment measurement. There were no significant differences between participants and non-participants (Table 2). A total of 16 office workers (3.5%) were sensitized only to Der p 1, 10 (2.2%) were sensitized only to Der f 1, and 217 (52.5%) were sensitized to Der p 1 or Der f 1. Many respondents were sensitized to cat allergy, but most of them were sensitized to both HDM and cat allergy (Fig 1). Participants with HDM allergy or cat allergy had significantly higher prevalence of asthma and respiratory symptoms (Table 3). In this study, 19.9% had cats in their current home. Those with cats at home had more daytime breathlessness at rest (OR = 1.81, 95%CI 1.05–3.13, p = 0.041) but there was no significant association between cat keeping and other types of respiratory symptoms. Moreover, there was no association between cat keeping and cat allergy (OR = 1.01, 95%CI 0.59–1.70, p = 1.000).


Asthma, Airway Symptoms and Rhinitis in Office Workers in Malaysia: Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust.

Lim FL, Hashim Z, Than LT, Md Said S, Hisham Hashim J, Norbäck D - PLoS ONE (2015)

Venn diagram for the distribution of subjects with a positive skin prick test to D. pteronyssinus, D. farinae and Felis domesticus in the group with skin prick test (n = 463).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414577&req=5

pone.0124905.g001: Venn diagram for the distribution of subjects with a positive skin prick test to D. pteronyssinus, D. farinae and Felis domesticus in the group with skin prick test (n = 463).
Mentions: We compared prevalence of asthma, rhinitis and eczema among participants and non-participants groups in the questionnaire study, the skin prick test, and the environment measurement. There were no significant differences between participants and non-participants (Table 2). A total of 16 office workers (3.5%) were sensitized only to Der p 1, 10 (2.2%) were sensitized only to Der f 1, and 217 (52.5%) were sensitized to Der p 1 or Der f 1. Many respondents were sensitized to cat allergy, but most of them were sensitized to both HDM and cat allergy (Fig 1). Participants with HDM allergy or cat allergy had significantly higher prevalence of asthma and respiratory symptoms (Table 3). In this study, 19.9% had cats in their current home. Those with cats at home had more daytime breathlessness at rest (OR = 1.81, 95%CI 1.05–3.13, p = 0.041) but there was no significant association between cat keeping and other types of respiratory symptoms. Moreover, there was no association between cat keeping and cat allergy (OR = 1.01, 95%CI 0.59–1.70, p = 1.000).

Bottom Line: Der f 1 level in dust was associated with daytime breathlessness (p= 0.033) especially among those with HDM allergy.In conclusion, HDM and cat allergies were common and independently associated with asthma, airway symptoms and rhinitis.Der f 1 allergen can be a risk factor for daytime breathlessness.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia.

ABSTRACT
A prevalence study was conducted among office workers in Malaysia (N= 695). The aim of this study was to examine associations between asthma, airway symptoms, rhinitis and house dust mites (HDM) and cat allergy and HDM levels in office dust. Medical data was collected by a questionnaire. Skin prick tests were performed for HDM allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) and cat allergen Felis domesticus. Indoor temperature and relative air humidity (RH) were measured in the offices and vacuumed dust samples were analyzed for HDM allergens. The prevalence of D. pteronyssinus, D. farinae and cat allergy were 50.3%, 49.0% and 25.5% respectively. Totally 9.6% had doctor-diagnosed asthma, 15.5% had current wheeze and 53.0% had current rhinitis. The Der p 1 (from D. pteronyssinus) and Der f 1 (from D. farinae) allergens levels in dust were 556 ng/g and 658 ng/g respectively. Statistical analysis was conducted by multilevel logistic regression, adjusting for age, gender, current smoking, HDM or cat allergy, home dampness and recent indoor painting at home. Office workers with HDM allergy had more wheeze (p= 0.035), any airway symptoms (p= 0.032), doctor-diagnosed asthma (p= 0.005), current asthma (p= 0.007), current rhinitis (p= 0.021) and rhinoconjuctivitis (p< 0.001). Cat allergy was associated with wheeze (p= 0.021), wheeze when not having a cold (p= 0.033), any airway symptoms (p= 0.034), doctor-diagnosed asthma (p= 0.010), current asthma (p= 0.020) and nasal allergy medication (p= 0.042). Der f 1 level in dust was associated with daytime breathlessness (p= 0.033) especially among those with HDM allergy. Der f 1 levels were correlated with indoor temperature (p< 0.001) and inversely correlated with RH (p< 0.001). In conclusion, HDM and cat allergies were common and independently associated with asthma, airway symptoms and rhinitis. Der f 1 allergen can be a risk factor for daytime breathlessness.

No MeSH data available.


Related in: MedlinePlus