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Traditional chinese medicine Xuebijing treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning.

Gong P, Lu Z, Xing J, Wang N, Zhang Y - PLoS ONE (2015)

Bottom Line: After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group.Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group.In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

View Article: PubMed Central - PubMed

Affiliation: Emergency Department, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning province, People's Republic of China.

ABSTRACT
Paraquat poisoning causes multiple organ injury and high mortality due to severe toxicity and lack of effective treatment. Xuebijing (XBJ) injection, a traditional Chinese medicine preparation of five Chinese herbs (Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra), has an anti-inflammatory effect and is widely used in the treatment of sepsis. This retrospective study was designed to evaluate the effects of XBJ combined with conventional therapy on mortality risk of patients with acute paraquat poisoning. Out of 68 patients, 27 were treated with conventional therapy (control group) and 41 were treated with intravenous administration of XBJ (100 ml, twice a day, up to 7 days) plus conventional therapy (XBJ group). Vital organ function, survival time within 28 days and adverse events during the treatment were reviewed. Results indicated that XBJ treatment significantly increased median survival time among patients ingesting 10-30 ml of paraquat (P=0.02) compared with the control group. After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group. Additionally, compared with Day 1, on Day 3 the value of PaO2/FiO2 was significantly decreased, and the values of serum alanine aminotransferase, creatinine and troponin T were significantly increased in the control group (all P<0.05), but these values were significant improved in the XBJ group (all P<0.05). Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group. In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

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Kaplan-Meier Survival Curves for (A) all patients and (B) patients ingesting 10–30 ml of 20% liquid paraquat (w/v).The differences in survival curves between the control and XBJ groups were not significant in A (P = 0.06), but significant in B (P = 0.02), as compared using a Log rank test. XBJ, Xuebijing injection.
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pone.0123504.g002: Kaplan-Meier Survival Curves for (A) all patients and (B) patients ingesting 10–30 ml of 20% liquid paraquat (w/v).The differences in survival curves between the control and XBJ groups were not significant in A (P = 0.06), but significant in B (P = 0.02), as compared using a Log rank test. XBJ, Xuebijing injection.

Mentions: Patients treated with XBJ had a slight increase in 28-day survival rate, compared with their counterparts in the control group, but this difference (15.5%) did not reach statistical significance (48.8% vs.33.3%, P = 0.21, Fig 2A). Similarly, the Kaplan—Meier survival curves (Fig 2A) showed that median survival time was slightly increased from 5.0 days (95% CI 3.3–6.7 days) with conventional therapy to 13 days (95% CI 6.5–18.6 days) with XBJ treatment plus conventional therapy, however Log rank tests indicated that there was no significant difference between the two survival curves (P = 0.06).


Traditional chinese medicine Xuebijing treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning.

Gong P, Lu Z, Xing J, Wang N, Zhang Y - PLoS ONE (2015)

Kaplan-Meier Survival Curves for (A) all patients and (B) patients ingesting 10–30 ml of 20% liquid paraquat (w/v).The differences in survival curves between the control and XBJ groups were not significant in A (P = 0.06), but significant in B (P = 0.02), as compared using a Log rank test. XBJ, Xuebijing injection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414552&req=5

pone.0123504.g002: Kaplan-Meier Survival Curves for (A) all patients and (B) patients ingesting 10–30 ml of 20% liquid paraquat (w/v).The differences in survival curves between the control and XBJ groups were not significant in A (P = 0.06), but significant in B (P = 0.02), as compared using a Log rank test. XBJ, Xuebijing injection.
Mentions: Patients treated with XBJ had a slight increase in 28-day survival rate, compared with their counterparts in the control group, but this difference (15.5%) did not reach statistical significance (48.8% vs.33.3%, P = 0.21, Fig 2A). Similarly, the Kaplan—Meier survival curves (Fig 2A) showed that median survival time was slightly increased from 5.0 days (95% CI 3.3–6.7 days) with conventional therapy to 13 days (95% CI 6.5–18.6 days) with XBJ treatment plus conventional therapy, however Log rank tests indicated that there was no significant difference between the two survival curves (P = 0.06).

Bottom Line: After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group.Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group.In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

View Article: PubMed Central - PubMed

Affiliation: Emergency Department, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning province, People's Republic of China.

ABSTRACT
Paraquat poisoning causes multiple organ injury and high mortality due to severe toxicity and lack of effective treatment. Xuebijing (XBJ) injection, a traditional Chinese medicine preparation of five Chinese herbs (Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra), has an anti-inflammatory effect and is widely used in the treatment of sepsis. This retrospective study was designed to evaluate the effects of XBJ combined with conventional therapy on mortality risk of patients with acute paraquat poisoning. Out of 68 patients, 27 were treated with conventional therapy (control group) and 41 were treated with intravenous administration of XBJ (100 ml, twice a day, up to 7 days) plus conventional therapy (XBJ group). Vital organ function, survival time within 28 days and adverse events during the treatment were reviewed. Results indicated that XBJ treatment significantly increased median survival time among patients ingesting 10-30 ml of paraquat (P=0.02) compared with the control group. After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group. Additionally, compared with Day 1, on Day 3 the value of PaO2/FiO2 was significantly decreased, and the values of serum alanine aminotransferase, creatinine and troponin T were significantly increased in the control group (all P<0.05), but these values were significant improved in the XBJ group (all P<0.05). Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group. In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

Show MeSH
Related in: MedlinePlus