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Traditional chinese medicine Xuebijing treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning.

Gong P, Lu Z, Xing J, Wang N, Zhang Y - PLoS ONE (2015)

Bottom Line: After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group.Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group.In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

View Article: PubMed Central - PubMed

Affiliation: Emergency Department, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning province, People's Republic of China.

ABSTRACT
Paraquat poisoning causes multiple organ injury and high mortality due to severe toxicity and lack of effective treatment. Xuebijing (XBJ) injection, a traditional Chinese medicine preparation of five Chinese herbs (Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra), has an anti-inflammatory effect and is widely used in the treatment of sepsis. This retrospective study was designed to evaluate the effects of XBJ combined with conventional therapy on mortality risk of patients with acute paraquat poisoning. Out of 68 patients, 27 were treated with conventional therapy (control group) and 41 were treated with intravenous administration of XBJ (100 ml, twice a day, up to 7 days) plus conventional therapy (XBJ group). Vital organ function, survival time within 28 days and adverse events during the treatment were reviewed. Results indicated that XBJ treatment significantly increased median survival time among patients ingesting 10-30 ml of paraquat (P=0.02) compared with the control group. After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group. Additionally, compared with Day 1, on Day 3 the value of PaO2/FiO2 was significantly decreased, and the values of serum alanine aminotransferase, creatinine and troponin T were significantly increased in the control group (all P<0.05), but these values were significant improved in the XBJ group (all P<0.05). Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group. In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

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Fingerprint chromatograph of XBJ.
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pone.0123504.g001: Fingerprint chromatograph of XBJ.

Mentions: Xuebijing (XBJ) injection, a traditional Chinese medicine preparation, is widely used in the treatment of sepsis in China; the possible mechanisms are believed to be associated with antagonizing pro-inflammatory factors [7–9]. XBJ is extracted from five Chinese herbs including Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra; at least 21 compounds have been found in XBJ, including amino acids, phenolic acids, flavonoid glycoside, terpene glycoside, and phthalide [8,10]. Radix Salviae Miltiorrhiae [11–15], Rhizoma Chuanxiong [16,17], Flos Carthami [18,19] and Angelica Sinensis [20–22] are known to exert anti-inflammatory effects. The quality of XBJ has been strictly controlled according to the standards of the China Ministry of Public Health, and fingerprint technology is adopted in the production as a quality control measure (Fig 1), so XBJ quality does not vary substantially from batch to batch or from laboratory to laboratory. Recently, XBJ has been used in patients with acute paraquat poisoning in China [23,24]. Zheng et al have reported that the treatment with XBJ plus conventional therapy significantly decreases transforming growth factor (TGF)-beta I and procollagen type III peptide (PIIIP) levels in patients with paraquat poisoning [24]. However, the clinical therapeutic efficacy of XBJ in patients with acute paraquat poisoning has not been well established. In the present study, we retrospectively reviewed laboratory and clinical data to determine the effects of XBJ in combination with conventional therapy on vital organ function and the survival of patients with acute paraquat poisoning.


Traditional chinese medicine Xuebijing treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning.

Gong P, Lu Z, Xing J, Wang N, Zhang Y - PLoS ONE (2015)

Fingerprint chromatograph of XBJ.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414552&req=5

pone.0123504.g001: Fingerprint chromatograph of XBJ.
Mentions: Xuebijing (XBJ) injection, a traditional Chinese medicine preparation, is widely used in the treatment of sepsis in China; the possible mechanisms are believed to be associated with antagonizing pro-inflammatory factors [7–9]. XBJ is extracted from five Chinese herbs including Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra; at least 21 compounds have been found in XBJ, including amino acids, phenolic acids, flavonoid glycoside, terpene glycoside, and phthalide [8,10]. Radix Salviae Miltiorrhiae [11–15], Rhizoma Chuanxiong [16,17], Flos Carthami [18,19] and Angelica Sinensis [20–22] are known to exert anti-inflammatory effects. The quality of XBJ has been strictly controlled according to the standards of the China Ministry of Public Health, and fingerprint technology is adopted in the production as a quality control measure (Fig 1), so XBJ quality does not vary substantially from batch to batch or from laboratory to laboratory. Recently, XBJ has been used in patients with acute paraquat poisoning in China [23,24]. Zheng et al have reported that the treatment with XBJ plus conventional therapy significantly decreases transforming growth factor (TGF)-beta I and procollagen type III peptide (PIIIP) levels in patients with paraquat poisoning [24]. However, the clinical therapeutic efficacy of XBJ in patients with acute paraquat poisoning has not been well established. In the present study, we retrospectively reviewed laboratory and clinical data to determine the effects of XBJ in combination with conventional therapy on vital organ function and the survival of patients with acute paraquat poisoning.

Bottom Line: After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group.Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group.In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

View Article: PubMed Central - PubMed

Affiliation: Emergency Department, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning province, People's Republic of China.

ABSTRACT
Paraquat poisoning causes multiple organ injury and high mortality due to severe toxicity and lack of effective treatment. Xuebijing (XBJ) injection, a traditional Chinese medicine preparation of five Chinese herbs (Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra), has an anti-inflammatory effect and is widely used in the treatment of sepsis. This retrospective study was designed to evaluate the effects of XBJ combined with conventional therapy on mortality risk of patients with acute paraquat poisoning. Out of 68 patients, 27 were treated with conventional therapy (control group) and 41 were treated with intravenous administration of XBJ (100 ml, twice a day, up to 7 days) plus conventional therapy (XBJ group). Vital organ function, survival time within 28 days and adverse events during the treatment were reviewed. Results indicated that XBJ treatment significantly increased median survival time among patients ingesting 10-30 ml of paraquat (P=0.02) compared with the control group. After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001) compared with the control group. Additionally, compared with Day 1, on Day 3 the value of PaO2/FiO2 was significantly decreased, and the values of serum alanine aminotransferase, creatinine and troponin T were significantly increased in the control group (all P<0.05), but these values were significant improved in the XBJ group (all P<0.05). Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group. In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

Show MeSH
Related in: MedlinePlus