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Diagnostic accuracy of computed tomography for chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis.

Dong C, Zhou M, Liu D, Long X, Guo T, Kong X - PLoS ONE (2015)

Bottom Line: This resulted in a pooled diagnostic odds ratio (DOR) of 191 (95%CI: 75 to 486).This resulted in a pooled diagnostic odds ratio of 76 (95%CI: 23 to 254),751 (95%CI: 57 to 9905) and 189 (95%CI: 21 to 1072), respectively.In the near future, CT could position itself as the key for screening consideration and for surgical and interventional operability.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

ABSTRACT
This study aimed to determine the diagnostic accuracy of computed tomography imaging for the diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH). Additionally, the effect of test and study characteristics was explored. Studies published between 1990 and 2015 identified by PubMed, OVID search and citation tracking were examined. Of the 613 citations, 11 articles (n=712) met the inclusion criteria. The patient-based analysis demonstrated a pooled sensitivity of 76% (95% confidence interval [CI]: 69% to 82%), and a pooled specificity of 96% (95%CI: 93% to 98%). This resulted in a pooled diagnostic odds ratio (DOR) of 191 (95%CI: 75 to 486). The vessel-based analyses were divided into 3 levels: total arteries、main+ lobar arteries and segmental arteries. The pooled sensitivity were 88% (95%CI: 87% to 90%)、95% (95%CI: 92% to 97%) and 88% (95%CI: 87% to 90%), respectively, with a pooled specificity of 90% (95%CI: 88% to 91%)、96% (95%CI: 94% to 97%) and 89% (95% CI: 87% to 91%). This resulted in a pooled diagnostic odds ratio of 76 (95%CI: 23 to 254),751 (95%CI: 57 to 9905) and 189 (95%CI: 21 to 1072), respectively. In conclusion, CT is a favorable method to rule in CTEPH and to rule out pulmonary endarterectomy (PEA) patients for proximal branches. Furthermore, dual-energy and 320-slices CT can increase the sensitivity for subsegmental arterials, which are promising imaging techniques for balloon pulmonary angioplasty (BPA) approach. In the near future, CT could position itself as the key for screening consideration and for surgical and interventional operability.

No MeSH data available.


Related in: MedlinePlus

Deek’s test to measure the funnel plot asymmetric.P-values less than 0.05 were considered representative of publication bias. (A) patient basis; (B) total arteries.
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pone.0126985.g007: Deek’s test to measure the funnel plot asymmetric.P-values less than 0.05 were considered representative of publication bias. (A) patient basis; (B) total arteries.

Mentions: The effective sample size funnel plot and associated regression test of asymmetry (Deeks 2005) were used to detect publication bias[17]. The results were shown in Fig 7. There was no evidence of publication bias in both patient-based and vessel-based analysis.


Diagnostic accuracy of computed tomography for chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis.

Dong C, Zhou M, Liu D, Long X, Guo T, Kong X - PLoS ONE (2015)

Deek’s test to measure the funnel plot asymmetric.P-values less than 0.05 were considered representative of publication bias. (A) patient basis; (B) total arteries.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414539&req=5

pone.0126985.g007: Deek’s test to measure the funnel plot asymmetric.P-values less than 0.05 were considered representative of publication bias. (A) patient basis; (B) total arteries.
Mentions: The effective sample size funnel plot and associated regression test of asymmetry (Deeks 2005) were used to detect publication bias[17]. The results were shown in Fig 7. There was no evidence of publication bias in both patient-based and vessel-based analysis.

Bottom Line: This resulted in a pooled diagnostic odds ratio (DOR) of 191 (95%CI: 75 to 486).This resulted in a pooled diagnostic odds ratio of 76 (95%CI: 23 to 254),751 (95%CI: 57 to 9905) and 189 (95%CI: 21 to 1072), respectively.In the near future, CT could position itself as the key for screening consideration and for surgical and interventional operability.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

ABSTRACT
This study aimed to determine the diagnostic accuracy of computed tomography imaging for the diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH). Additionally, the effect of test and study characteristics was explored. Studies published between 1990 and 2015 identified by PubMed, OVID search and citation tracking were examined. Of the 613 citations, 11 articles (n=712) met the inclusion criteria. The patient-based analysis demonstrated a pooled sensitivity of 76% (95% confidence interval [CI]: 69% to 82%), and a pooled specificity of 96% (95%CI: 93% to 98%). This resulted in a pooled diagnostic odds ratio (DOR) of 191 (95%CI: 75 to 486). The vessel-based analyses were divided into 3 levels: total arteries、main+ lobar arteries and segmental arteries. The pooled sensitivity were 88% (95%CI: 87% to 90%)、95% (95%CI: 92% to 97%) and 88% (95%CI: 87% to 90%), respectively, with a pooled specificity of 90% (95%CI: 88% to 91%)、96% (95%CI: 94% to 97%) and 89% (95% CI: 87% to 91%). This resulted in a pooled diagnostic odds ratio of 76 (95%CI: 23 to 254),751 (95%CI: 57 to 9905) and 189 (95%CI: 21 to 1072), respectively. In conclusion, CT is a favorable method to rule in CTEPH and to rule out pulmonary endarterectomy (PEA) patients for proximal branches. Furthermore, dual-energy and 320-slices CT can increase the sensitivity for subsegmental arterials, which are promising imaging techniques for balloon pulmonary angioplasty (BPA) approach. In the near future, CT could position itself as the key for screening consideration and for surgical and interventional operability.

No MeSH data available.


Related in: MedlinePlus