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Anal Human Papillomavirus Genotyping among HIV-Positive Men Who Have Sex with Men in Xi'an, China.

Li Z, Zhang H, Li X, Yang Y, Xin H, Li M, Feng B, Gao L - PLoS ONE (2015)

Bottom Line: As for low-risk types, HPV11, HPV 6 and HPV 81 were most commonly observe.High-risk HPV infection was found to be associated with the status of antiretroviral therapy (ART), the distribution of low-risk types was observed to be varied by CD4+ T cell level.Almost all HIV-positive MSM were anal HPV infected in our study.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Dan San Tiao No. 9, Beijing, 100730, China.

ABSTRACT

Background: Anal human papillomavirus (HPV) infection and its related diseases are relatively common in men who have sex with men (MSM), especially in those HIV positive. In China, molecular epidemiology of anal HPV infection among HIV-positive MSM has been sparsely studied.

Methods: A cross-sectional study was conducted among HIV-positive MSM in Xi'an, China between April and July 2014. Anal swabs were collected for HPV genotyping.

Results: A total of 195 HIV-positive MSM were included in this study. HPV genotyping showed that 99.0% (191/193) of participants were positive for at least one of the targeted 37 HPV genotypes. 183 (94.8%) of them were infected with multiple high-risk types and 154 (79.8%) of them with low-risk HPV types. HPV 18 was the most frequently identified high-risk type, followed by HPV 16 and HPV 51. As for low-risk types, HPV11, HPV 6 and HPV 81 were most commonly observe. High-risk HPV infection was found to be associated with the status of antiretroviral therapy (ART), the distribution of low-risk types was observed to be varied by CD4+ T cell level.

Conclusion: Almost all HIV-positive MSM were anal HPV infected in our study. It is highly recommended to consider regular active screening and preventive intervention of HPV infection among this high risk population.

No MeSH data available.


Related in: MedlinePlus

Prevalence of HPV types in 193 HIV-positive MSM.The numbers above the bars indicate the proportion of the patients in each category. HPV 11 and HPV 6 were found to be the most prevalent low-risk types, HPV 18 and HPV 16 were most common high-risk types among the study population.
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pone.0125120.g001: Prevalence of HPV types in 193 HIV-positive MSM.The numbers above the bars indicate the proportion of the patients in each category. HPV 11 and HPV 6 were found to be the most prevalent low-risk types, HPV 18 and HPV 16 were most common high-risk types among the study population.

Mentions: Fig 1A showed the prevalence of type-specific HPV infection. HPV 11 (59.7%) and HPV 6 (39.6%) were found to be the most frequently identified LR-HPV. The following prevalent LR-HPV genotypes were: HPV 81 (23.4%), HPV 61 (18.2%), HPV 84 (11.0%), HPV 73 (10.4%), and HPV 70 (9.1%). As depicted in Fig 1B, among the HR-HPV types, HPV 18, HPV 16, and HPV 51 were most frequently identified (40.4%, 33.9% and 31.7%, respectively). HPV 33, along with HPV 39, HPV 58, HPV 52, HPV 53, HPV 68, HPV 66, HPV 31, and HPV 59 were the following common detected HR-HPV types, with prevalence of 26.2%, 24.6%, 24.6%, 24.0%, 20.2%, 19.7%, 19.1%, 15.3%, and 11.5%, respectively.


Anal Human Papillomavirus Genotyping among HIV-Positive Men Who Have Sex with Men in Xi'an, China.

Li Z, Zhang H, Li X, Yang Y, Xin H, Li M, Feng B, Gao L - PLoS ONE (2015)

Prevalence of HPV types in 193 HIV-positive MSM.The numbers above the bars indicate the proportion of the patients in each category. HPV 11 and HPV 6 were found to be the most prevalent low-risk types, HPV 18 and HPV 16 were most common high-risk types among the study population.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414525&req=5

pone.0125120.g001: Prevalence of HPV types in 193 HIV-positive MSM.The numbers above the bars indicate the proportion of the patients in each category. HPV 11 and HPV 6 were found to be the most prevalent low-risk types, HPV 18 and HPV 16 were most common high-risk types among the study population.
Mentions: Fig 1A showed the prevalence of type-specific HPV infection. HPV 11 (59.7%) and HPV 6 (39.6%) were found to be the most frequently identified LR-HPV. The following prevalent LR-HPV genotypes were: HPV 81 (23.4%), HPV 61 (18.2%), HPV 84 (11.0%), HPV 73 (10.4%), and HPV 70 (9.1%). As depicted in Fig 1B, among the HR-HPV types, HPV 18, HPV 16, and HPV 51 were most frequently identified (40.4%, 33.9% and 31.7%, respectively). HPV 33, along with HPV 39, HPV 58, HPV 52, HPV 53, HPV 68, HPV 66, HPV 31, and HPV 59 were the following common detected HR-HPV types, with prevalence of 26.2%, 24.6%, 24.6%, 24.0%, 20.2%, 19.7%, 19.1%, 15.3%, and 11.5%, respectively.

Bottom Line: As for low-risk types, HPV11, HPV 6 and HPV 81 were most commonly observe.High-risk HPV infection was found to be associated with the status of antiretroviral therapy (ART), the distribution of low-risk types was observed to be varied by CD4+ T cell level.Almost all HIV-positive MSM were anal HPV infected in our study.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Dan San Tiao No. 9, Beijing, 100730, China.

ABSTRACT

Background: Anal human papillomavirus (HPV) infection and its related diseases are relatively common in men who have sex with men (MSM), especially in those HIV positive. In China, molecular epidemiology of anal HPV infection among HIV-positive MSM has been sparsely studied.

Methods: A cross-sectional study was conducted among HIV-positive MSM in Xi'an, China between April and July 2014. Anal swabs were collected for HPV genotyping.

Results: A total of 195 HIV-positive MSM were included in this study. HPV genotyping showed that 99.0% (191/193) of participants were positive for at least one of the targeted 37 HPV genotypes. 183 (94.8%) of them were infected with multiple high-risk types and 154 (79.8%) of them with low-risk HPV types. HPV 18 was the most frequently identified high-risk type, followed by HPV 16 and HPV 51. As for low-risk types, HPV11, HPV 6 and HPV 81 were most commonly observe. High-risk HPV infection was found to be associated with the status of antiretroviral therapy (ART), the distribution of low-risk types was observed to be varied by CD4+ T cell level.

Conclusion: Almost all HIV-positive MSM were anal HPV infected in our study. It is highly recommended to consider regular active screening and preventive intervention of HPV infection among this high risk population.

No MeSH data available.


Related in: MedlinePlus