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The Lao Experience in Deploying Influenza A(H1N1)pdm09 Vaccine: Lessons Made Relevant in Preparing for Present Day Pandemic Threats.

Xeuatvongsa A, Mirza S, Winter C, Feldon K, Vongphrachanh P, Phonekeo D, Denny J, Khanthamaly V, Kounnavong B, Lylianou D, Phousavath S, Norasingh S, Boutta N, Olsen S, Bresee J, Moen A, Corwin A - PLoS ONE (2015)

Bottom Line: Public acceptability of the vaccine campaign was high (98%).Challenges to vaccine deployment included: 1) no previous experience in fielding a seasonal influenza vaccine, 2) safety and efficacy concerns, and 3) late arrival of vaccine 10 months into the pandemic.The Lao "lessons learned" from pandemic vaccine deployment are made even more relevant four years on, given the many avian influenza strains circulating in the region, all with pandemic potential.

View Article: PubMed Central - PubMed

Affiliation: National Immunization Program, Ministry of Health, Vientiane, Lao People's Democratic Republic (Lao PDR).

ABSTRACT
The Lao PDR, as did most countries of the Mekong Region, embarked on a pandemic vaccine initiative to counter the threat posed by influenza A(H1N1)pdm09. Overall, estimated vaccine coverage of the Lao population was 14%, with uptake in targeted health care workers and pregnant women 99% and 41%, respectively. Adverse Events Following Immunization accounted for only 6% of survey driven, reported vaccination experiences, with no severe consequences or deaths. Public acceptability of the vaccine campaign was high (98%). Challenges to vaccine deployment included: 1) no previous experience in fielding a seasonal influenza vaccine, 2) safety and efficacy concerns, and 3) late arrival of vaccine 10 months into the pandemic. The Lao success in surmounting these hurdles was in large measure attributed to the oversight assigned the National Immunization Program, and national sensitivities in responding to the avian influenza A(H5N1) crisis in the years leading up to the pandemic. The Lao "lessons learned" from pandemic vaccine deployment are made even more relevant four years on, given the many avian influenza strains circulating in the region, all with pandemic potential.

No MeSH data available.


Related in: MedlinePlus

Reported AEFIs by Targeted Populations Surveyed.Lao PDR National Immunization Program (NIP), Anonh Xeuatvongsa, Director of National Immunization Program, Ministry of Health, Lao Peoples Democratic Republic, email address: anonhxeuat@gmail.com.
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pone.0121717.g002: Reported AEFIs by Targeted Populations Surveyed.Lao PDR National Immunization Program (NIP), Anonh Xeuatvongsa, Director of National Immunization Program, Ministry of Health, Lao Peoples Democratic Republic, email address: anonhxeuat@gmail.com.

Mentions: Among survey participants, 69 (5.7%) reported at least one mild AEFI. No serious adverse events such as seizure, paralysis or death were reported. Of AEFIs reported, most common was myalgia (72%), followed by reported fever (32%), headaches (22%) and localized reaction (7.2%) (Fig 2). The majority of participants (58%) reported only one symptom, 25% reported two symptoms and < 10% reported three or more. Overall, 122 (10%) respondents were pregnant among whom 8 (7%) reported an AEFI. No spontaneous abortions were reported. Of the 1,204 respondents, 315 (26%) reported having a maternal tetanus toxoid vaccination at the same time. Of those 42 (13%) reported an AEFI. Persons who received tetanus vaccine and influenza vaccine simultaneously were more likely to report AEFI compared to those only receiving an influenza vaccine (42/315, 13% vs. 27/889, 3%, p<0.01).


The Lao Experience in Deploying Influenza A(H1N1)pdm09 Vaccine: Lessons Made Relevant in Preparing for Present Day Pandemic Threats.

Xeuatvongsa A, Mirza S, Winter C, Feldon K, Vongphrachanh P, Phonekeo D, Denny J, Khanthamaly V, Kounnavong B, Lylianou D, Phousavath S, Norasingh S, Boutta N, Olsen S, Bresee J, Moen A, Corwin A - PLoS ONE (2015)

Reported AEFIs by Targeted Populations Surveyed.Lao PDR National Immunization Program (NIP), Anonh Xeuatvongsa, Director of National Immunization Program, Ministry of Health, Lao Peoples Democratic Republic, email address: anonhxeuat@gmail.com.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414524&req=5

pone.0121717.g002: Reported AEFIs by Targeted Populations Surveyed.Lao PDR National Immunization Program (NIP), Anonh Xeuatvongsa, Director of National Immunization Program, Ministry of Health, Lao Peoples Democratic Republic, email address: anonhxeuat@gmail.com.
Mentions: Among survey participants, 69 (5.7%) reported at least one mild AEFI. No serious adverse events such as seizure, paralysis or death were reported. Of AEFIs reported, most common was myalgia (72%), followed by reported fever (32%), headaches (22%) and localized reaction (7.2%) (Fig 2). The majority of participants (58%) reported only one symptom, 25% reported two symptoms and < 10% reported three or more. Overall, 122 (10%) respondents were pregnant among whom 8 (7%) reported an AEFI. No spontaneous abortions were reported. Of the 1,204 respondents, 315 (26%) reported having a maternal tetanus toxoid vaccination at the same time. Of those 42 (13%) reported an AEFI. Persons who received tetanus vaccine and influenza vaccine simultaneously were more likely to report AEFI compared to those only receiving an influenza vaccine (42/315, 13% vs. 27/889, 3%, p<0.01).

Bottom Line: Public acceptability of the vaccine campaign was high (98%).Challenges to vaccine deployment included: 1) no previous experience in fielding a seasonal influenza vaccine, 2) safety and efficacy concerns, and 3) late arrival of vaccine 10 months into the pandemic.The Lao "lessons learned" from pandemic vaccine deployment are made even more relevant four years on, given the many avian influenza strains circulating in the region, all with pandemic potential.

View Article: PubMed Central - PubMed

Affiliation: National Immunization Program, Ministry of Health, Vientiane, Lao People's Democratic Republic (Lao PDR).

ABSTRACT
The Lao PDR, as did most countries of the Mekong Region, embarked on a pandemic vaccine initiative to counter the threat posed by influenza A(H1N1)pdm09. Overall, estimated vaccine coverage of the Lao population was 14%, with uptake in targeted health care workers and pregnant women 99% and 41%, respectively. Adverse Events Following Immunization accounted for only 6% of survey driven, reported vaccination experiences, with no severe consequences or deaths. Public acceptability of the vaccine campaign was high (98%). Challenges to vaccine deployment included: 1) no previous experience in fielding a seasonal influenza vaccine, 2) safety and efficacy concerns, and 3) late arrival of vaccine 10 months into the pandemic. The Lao success in surmounting these hurdles was in large measure attributed to the oversight assigned the National Immunization Program, and national sensitivities in responding to the avian influenza A(H5N1) crisis in the years leading up to the pandemic. The Lao "lessons learned" from pandemic vaccine deployment are made even more relevant four years on, given the many avian influenza strains circulating in the region, all with pandemic potential.

No MeSH data available.


Related in: MedlinePlus