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Field evaluation of a push-pull system to reduce malaria transmission.

Menger DJ, Omusula P, Holdinga M, Homan T, Carreira AS, Vandendaele P, Derycke JL, Mweresa CK, Mukabana WR, van Loon JJ, Takken W - PLoS ONE (2015)

Bottom Line: Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations.Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes.Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Entomology, Wageningen University, P.O. Box 8031, 6700 EH, Wageningen, The Netherlands.

ABSTRACT
Malaria continues to place a disease burden on millions of people throughout the tropics, especially in sub-Saharan Africa. Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations. A mosquito-directed push-pull system based on the simultaneous use of attractive and repellent volatiles offers a complementary tool to existing vector-control methods. In this study, the combination of a trap baited with a five-compound attractant and a strip of net-fabric impregnated with micro-encapsulated repellent and placed in the eaves of houses, was tested in a malaria-endemic village in western Kenya. Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes. Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate. Reductions of such magnitude are also predicted when mosquitoes exhibit a high resistance against insecticides. We conclude that a push-pull system based on non-toxic volatiles provides an important addition to existing strategies for malaria prevention.

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Related in: MedlinePlus

The components of the push-pull system.Panels A and B: The 10 cm wide strip of fabric as it was applied inside the eave, around the full circumference of the house. Panel C: The attractant baited MM-X trap as it was installed outside the house.
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pone.0123415.g007: The components of the push-pull system.Panels A and B: The 10 cm wide strip of fabric as it was applied inside the eave, around the full circumference of the house. Panel C: The attractant baited MM-X trap as it was installed outside the house.

Mentions: The repellent was released from a 10 cm wide strip of the fabric described above, which was applied inside the eave, around the full circumference of the house (Fig 7A and 7B). The strip was stretched in the lower part of the eave, closing off only the bottom 10 cm but leaving ample space for mosquitoes to enter the house. The control and pull-only treatments received an untreated strip of fabric that was applied the same way as the treated fabric used in the push and push-pull treatments. Strips remained in place over the entire study. See Table 4 for a comprehensive overview of the presence/absence of the specific elements during the treatments.


Field evaluation of a push-pull system to reduce malaria transmission.

Menger DJ, Omusula P, Holdinga M, Homan T, Carreira AS, Vandendaele P, Derycke JL, Mweresa CK, Mukabana WR, van Loon JJ, Takken W - PLoS ONE (2015)

The components of the push-pull system.Panels A and B: The 10 cm wide strip of fabric as it was applied inside the eave, around the full circumference of the house. Panel C: The attractant baited MM-X trap as it was installed outside the house.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4414508&req=5

pone.0123415.g007: The components of the push-pull system.Panels A and B: The 10 cm wide strip of fabric as it was applied inside the eave, around the full circumference of the house. Panel C: The attractant baited MM-X trap as it was installed outside the house.
Mentions: The repellent was released from a 10 cm wide strip of the fabric described above, which was applied inside the eave, around the full circumference of the house (Fig 7A and 7B). The strip was stretched in the lower part of the eave, closing off only the bottom 10 cm but leaving ample space for mosquitoes to enter the house. The control and pull-only treatments received an untreated strip of fabric that was applied the same way as the treated fabric used in the push and push-pull treatments. Strips remained in place over the entire study. See Table 4 for a comprehensive overview of the presence/absence of the specific elements during the treatments.

Bottom Line: Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations.Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes.Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Entomology, Wageningen University, P.O. Box 8031, 6700 EH, Wageningen, The Netherlands.

ABSTRACT
Malaria continues to place a disease burden on millions of people throughout the tropics, especially in sub-Saharan Africa. Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations. A mosquito-directed push-pull system based on the simultaneous use of attractive and repellent volatiles offers a complementary tool to existing vector-control methods. In this study, the combination of a trap baited with a five-compound attractant and a strip of net-fabric impregnated with micro-encapsulated repellent and placed in the eaves of houses, was tested in a malaria-endemic village in western Kenya. Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes. Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate. Reductions of such magnitude are also predicted when mosquitoes exhibit a high resistance against insecticides. We conclude that a push-pull system based on non-toxic volatiles provides an important addition to existing strategies for malaria prevention.

Show MeSH
Related in: MedlinePlus