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Increased of serum high-mobility group box chromosomal protein 1 correlated with intestinal mucosal barrier injury in patients with severe acute pancreatitis.

Xu GF, Guo M, Tian ZQ, Wu GZ, Zou XP, Zhang WJ - World J Emerg Surg (2014)

Bottom Line: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL).Serum HMGB1 levels were significantly positively correlated with the Ranson score.The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Nanjing Drum tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

ABSTRACT

Background: Secondary infections are the leading cause of death in patients with severe acute pancreatitis (SAP). The gut represents the main source of pancreatic contamination and related septic complications. High-mobility group box chromosomal protein 1 (HMGB1) was recently identified to play an important role in the SAP intestinal mucosal barrier dysfunction.

Objective: To investigate the correlation of high-mobility group box 1 (HMGB1) with intestinal barrier injury and infections in patients with severe acute pancreatitis (SAP).

Methods: The serum levels of HMGB1, amylase, lipase, and biochemical indicators were measured in 80 patients with SAP at the time of admission. Furthermore, relationship between their serum HMGB1 levels and intestinal barrier injury, infection and other clinical factors were analyzed.

Results: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL). Serum HMGB1 levels were significantly positively correlated with the Ranson score. The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

Conclusions: HMGBl level of patients with severe acute pancreatitis was significantly increased, and can be used as an important indicator to determine the intestinal barrier dysfunction and infection.

No MeSH data available.


Related in: MedlinePlus

Correlation efficient of serum HMGB1 levels with intestinal mucosal barrier parameters (plasma DAO activity, serum endotoxin, urinary L/M ratio).
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Fig3: Correlation efficient of serum HMGB1 levels with intestinal mucosal barrier parameters (plasma DAO activity, serum endotoxin, urinary L/M ratio).

Mentions: Correlation efficient of serum HMGB1 levels with intestinal mucosal barrier parameters on admission was investigated, and found that plasma DAO activity, serum endotoxin, urinary lactulose and mannitol ratio (L/M) were significantly positively correlated with serum HMGB1 levels (R = 0.484, P < 0.01, Figure 3).Figure 3


Increased of serum high-mobility group box chromosomal protein 1 correlated with intestinal mucosal barrier injury in patients with severe acute pancreatitis.

Xu GF, Guo M, Tian ZQ, Wu GZ, Zou XP, Zhang WJ - World J Emerg Surg (2014)

Correlation efficient of serum HMGB1 levels with intestinal mucosal barrier parameters (plasma DAO activity, serum endotoxin, urinary L/M ratio).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4414458&req=5

Fig3: Correlation efficient of serum HMGB1 levels with intestinal mucosal barrier parameters (plasma DAO activity, serum endotoxin, urinary L/M ratio).
Mentions: Correlation efficient of serum HMGB1 levels with intestinal mucosal barrier parameters on admission was investigated, and found that plasma DAO activity, serum endotoxin, urinary lactulose and mannitol ratio (L/M) were significantly positively correlated with serum HMGB1 levels (R = 0.484, P < 0.01, Figure 3).Figure 3

Bottom Line: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL).Serum HMGB1 levels were significantly positively correlated with the Ranson score.The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Nanjing Drum tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

ABSTRACT

Background: Secondary infections are the leading cause of death in patients with severe acute pancreatitis (SAP). The gut represents the main source of pancreatic contamination and related septic complications. High-mobility group box chromosomal protein 1 (HMGB1) was recently identified to play an important role in the SAP intestinal mucosal barrier dysfunction.

Objective: To investigate the correlation of high-mobility group box 1 (HMGB1) with intestinal barrier injury and infections in patients with severe acute pancreatitis (SAP).

Methods: The serum levels of HMGB1, amylase, lipase, and biochemical indicators were measured in 80 patients with SAP at the time of admission. Furthermore, relationship between their serum HMGB1 levels and intestinal barrier injury, infection and other clinical factors were analyzed.

Results: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL). Serum HMGB1 levels were significantly positively correlated with the Ranson score. The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

Conclusions: HMGBl level of patients with severe acute pancreatitis was significantly increased, and can be used as an important indicator to determine the intestinal barrier dysfunction and infection.

No MeSH data available.


Related in: MedlinePlus