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Increased of serum high-mobility group box chromosomal protein 1 correlated with intestinal mucosal barrier injury in patients with severe acute pancreatitis.

Xu GF, Guo M, Tian ZQ, Wu GZ, Zou XP, Zhang WJ - World J Emerg Surg (2014)

Bottom Line: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL).Serum HMGB1 levels were significantly positively correlated with the Ranson score.The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Nanjing Drum tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

ABSTRACT

Background: Secondary infections are the leading cause of death in patients with severe acute pancreatitis (SAP). The gut represents the main source of pancreatic contamination and related septic complications. High-mobility group box chromosomal protein 1 (HMGB1) was recently identified to play an important role in the SAP intestinal mucosal barrier dysfunction.

Objective: To investigate the correlation of high-mobility group box 1 (HMGB1) with intestinal barrier injury and infections in patients with severe acute pancreatitis (SAP).

Methods: The serum levels of HMGB1, amylase, lipase, and biochemical indicators were measured in 80 patients with SAP at the time of admission. Furthermore, relationship between their serum HMGB1 levels and intestinal barrier injury, infection and other clinical factors were analyzed.

Results: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL). Serum HMGB1 levels were significantly positively correlated with the Ranson score. The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

Conclusions: HMGBl level of patients with severe acute pancreatitis was significantly increased, and can be used as an important indicator to determine the intestinal barrier dysfunction and infection.

No MeSH data available.


Related in: MedlinePlus

Correlation of serum high-mobility group box chromosomal protein 1 levels with blood biochemical parameters on admission in patients with severe acute pancreatitis.
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Fig1: Correlation of serum high-mobility group box chromosomal protein 1 levels with blood biochemical parameters on admission in patients with severe acute pancreatitis.

Mentions: Correlation efficient of serum HMGB1 levels with various blood biochemical parameters on admission was investigated. Procalcitonin, total bilirubin and C-reactive protein were significantly positively correlated with serum HMGB1 levels (R = 0.393, P < 0.05, Figure 1). We could not find the significant correlation between other parameters (amylase, etc.) and serum HMGB1 levels. The value of HMGB1 versus amylase, lipase, ALT, and AST was R = 0.118, P = 0.297; R = 0.175, P = 0.120; R = 0.122 p = 0.286, and R = 0.156 p = 0.174, respectively.Figure 1


Increased of serum high-mobility group box chromosomal protein 1 correlated with intestinal mucosal barrier injury in patients with severe acute pancreatitis.

Xu GF, Guo M, Tian ZQ, Wu GZ, Zou XP, Zhang WJ - World J Emerg Surg (2014)

Correlation of serum high-mobility group box chromosomal protein 1 levels with blood biochemical parameters on admission in patients with severe acute pancreatitis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4414458&req=5

Fig1: Correlation of serum high-mobility group box chromosomal protein 1 levels with blood biochemical parameters on admission in patients with severe acute pancreatitis.
Mentions: Correlation efficient of serum HMGB1 levels with various blood biochemical parameters on admission was investigated. Procalcitonin, total bilirubin and C-reactive protein were significantly positively correlated with serum HMGB1 levels (R = 0.393, P < 0.05, Figure 1). We could not find the significant correlation between other parameters (amylase, etc.) and serum HMGB1 levels. The value of HMGB1 versus amylase, lipase, ALT, and AST was R = 0.118, P = 0.297; R = 0.175, P = 0.120; R = 0.122 p = 0.286, and R = 0.156 p = 0.174, respectively.Figure 1

Bottom Line: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL).Serum HMGB1 levels were significantly positively correlated with the Ranson score.The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Nanjing Drum tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

ABSTRACT

Background: Secondary infections are the leading cause of death in patients with severe acute pancreatitis (SAP). The gut represents the main source of pancreatic contamination and related septic complications. High-mobility group box chromosomal protein 1 (HMGB1) was recently identified to play an important role in the SAP intestinal mucosal barrier dysfunction.

Objective: To investigate the correlation of high-mobility group box 1 (HMGB1) with intestinal barrier injury and infections in patients with severe acute pancreatitis (SAP).

Methods: The serum levels of HMGB1, amylase, lipase, and biochemical indicators were measured in 80 patients with SAP at the time of admission. Furthermore, relationship between their serum HMGB1 levels and intestinal barrier injury, infection and other clinical factors were analyzed.

Results: The mean value of serum HMGB1 levels was significantly higher in patients with SAP (6.02 ± 2.42 ng/mL) than that in healthy volunteers (1.87 ± 0.63 ng/mL). Serum HMGB1 levels were significantly positively correlated with the Ranson score. The HMGB1 levels were higher in patients with infection during the clinical course, the HMGB1 levels in non-survivors were higher than those in survivors, and positively correlated with DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01).

Conclusions: HMGBl level of patients with severe acute pancreatitis was significantly increased, and can be used as an important indicator to determine the intestinal barrier dysfunction and infection.

No MeSH data available.


Related in: MedlinePlus