Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat.
Bottom Line: Spinal administration of ProTxII significantly reduced neuronal responses evoked by mechanical punctate (von Frey (vF) 8-60g) and noxious thermal (45 and 48°C) stimuli in MIA rats only.The observed selective inhibitory effect of ProTxII and A-803467 for the MIA-treated group suggests an increased role of Nav1.7 and 1.8 within nociceptive pathways in the arthritic condition, located at peripheral and central sites.These findings demonstrate the importance of, and add to, the mechanistic understanding of these channels in osteoarthritic pain.
Affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: firstname.lastname@example.org.Show MeSH
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Mentions: Spinal administration of A-803467 reduced some of the electrical evoked neuronal responses in both MIA and sham groups, but these effects did not reach significance (Fig. 2a, b). In complete contrast, A-803467 produced a clear MIA group-dependent inhibition of many of the mechanical- and thermal evoked neuronal responses; in particular the mechanical evoked responses in the MIA group were highly sensitive to the inhibitory effects of A-803467 (Fig. 2d, f).
Affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: email@example.com.