Limits...
Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network.

Dong Y, Kuang Q, Dai X, Li R, Wu Y, Leng W, Li Y, Li M - Biomed Res Int (2015)

Bottom Line: Furthermore, not only was HPV16 highly prone to interact with hub proteins and bottleneck proteins, but also it could effectively affect a breadth of signaling pathways.In addition, we found that the HPV16 evolved into high carcinogenicity on the condition that its own reproduction had been ensured.Meanwhile, this work will contribute to providing potential new targets for antiviral therapeutics and help experimental research in the future.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China.

ABSTRACT
The human papillomavirus 16 (HPV16) has high risk to lead various cancers and afflictions, especially, the cervical cancer. Therefore, investigating the pathogenesis of HPV16 is very important for public health. Protein-protein interaction (PPI) network between HPV16 and human was used as a measure to improve our understanding of its pathogenesis. By adopting sequence and topological features, a support vector machine (SVM) model was built to predict new interactions between HPV16 and human proteins. All interactions were comprehensively investigated and analyzed. The analysis indicated that HPV16 enlarged its scope of influence by interacting with human proteins as much as possible. These interactions alter a broad array of cell cycle progression. Furthermore, not only was HPV16 highly prone to interact with hub proteins and bottleneck proteins, but also it could effectively affect a breadth of signaling pathways. In addition, we found that the HPV16 evolved into high carcinogenicity on the condition that its own reproduction had been ensured. Meanwhile, this work will contribute to providing potential new targets for antiviral therapeutics and help experimental research in the future.

No MeSH data available.


Related in: MedlinePlus

Significantly enriched GO biological process terms. (a) Enriched results of E1, E2, L2, and L1. (b) Enriched results of E4. (c) Enriched results of E5, E6, and E7. Here only fifteen most significant terms are shown. Bonferroni collected P values were transformed by −log⁡10⁡.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4414230&req=5

fig6: Significantly enriched GO biological process terms. (a) Enriched results of E1, E2, L2, and L1. (b) Enriched results of E4. (c) Enriched results of E5, E6, and E7. Here only fifteen most significant terms are shown. Bonferroni collected P values were transformed by −log⁡10⁡.

Mentions: Five proteins (E1, E2 (and E4), L1, and L2) are encoded by all known PVs. There is a hypothesis that the ancestral papillomavirus did not contain adaptive proteins and only need the core set to meet the basic requirements of a viral infection [11]. In the process of evolution, HPV16 produced all of the adaptive proteins. It was surprising that the top four of biological process enrichment of all adaptive proteins were the same as core set's top four, and then processes involving apoptosis and death were enriched for core set (Figures 6(a) and 6(c)). This showed that HPV16 would evolve carcinogenicity, but only on the condition that its own reproduction had been ensured. The E4 protein has the functions of adaptive proteins and core set (Figure 6) but prefers the latter. In other words, as a part of the proteins encoded by all known PVs E4 must first guarantee viral reproduction and then together with adaptive proteins enhance the carcinogenicity of HPV16.


Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network.

Dong Y, Kuang Q, Dai X, Li R, Wu Y, Leng W, Li Y, Li M - Biomed Res Int (2015)

Significantly enriched GO biological process terms. (a) Enriched results of E1, E2, L2, and L1. (b) Enriched results of E4. (c) Enriched results of E5, E6, and E7. Here only fifteen most significant terms are shown. Bonferroni collected P values were transformed by −log⁡10⁡.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4414230&req=5

fig6: Significantly enriched GO biological process terms. (a) Enriched results of E1, E2, L2, and L1. (b) Enriched results of E4. (c) Enriched results of E5, E6, and E7. Here only fifteen most significant terms are shown. Bonferroni collected P values were transformed by −log⁡10⁡.
Mentions: Five proteins (E1, E2 (and E4), L1, and L2) are encoded by all known PVs. There is a hypothesis that the ancestral papillomavirus did not contain adaptive proteins and only need the core set to meet the basic requirements of a viral infection [11]. In the process of evolution, HPV16 produced all of the adaptive proteins. It was surprising that the top four of biological process enrichment of all adaptive proteins were the same as core set's top four, and then processes involving apoptosis and death were enriched for core set (Figures 6(a) and 6(c)). This showed that HPV16 would evolve carcinogenicity, but only on the condition that its own reproduction had been ensured. The E4 protein has the functions of adaptive proteins and core set (Figure 6) but prefers the latter. In other words, as a part of the proteins encoded by all known PVs E4 must first guarantee viral reproduction and then together with adaptive proteins enhance the carcinogenicity of HPV16.

Bottom Line: Furthermore, not only was HPV16 highly prone to interact with hub proteins and bottleneck proteins, but also it could effectively affect a breadth of signaling pathways.In addition, we found that the HPV16 evolved into high carcinogenicity on the condition that its own reproduction had been ensured.Meanwhile, this work will contribute to providing potential new targets for antiviral therapeutics and help experimental research in the future.

View Article: PubMed Central - PubMed

Affiliation: College of Life Sciences, Sichuan University, Chengdu 610064, China.

ABSTRACT
The human papillomavirus 16 (HPV16) has high risk to lead various cancers and afflictions, especially, the cervical cancer. Therefore, investigating the pathogenesis of HPV16 is very important for public health. Protein-protein interaction (PPI) network between HPV16 and human was used as a measure to improve our understanding of its pathogenesis. By adopting sequence and topological features, a support vector machine (SVM) model was built to predict new interactions between HPV16 and human proteins. All interactions were comprehensively investigated and analyzed. The analysis indicated that HPV16 enlarged its scope of influence by interacting with human proteins as much as possible. These interactions alter a broad array of cell cycle progression. Furthermore, not only was HPV16 highly prone to interact with hub proteins and bottleneck proteins, but also it could effectively affect a breadth of signaling pathways. In addition, we found that the HPV16 evolved into high carcinogenicity on the condition that its own reproduction had been ensured. Meanwhile, this work will contribute to providing potential new targets for antiviral therapeutics and help experimental research in the future.

No MeSH data available.


Related in: MedlinePlus