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Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis.

Yang Y, Wang Z, Zhou Y, Wang X, Xiang J, Chen Z - World J Surg Oncol (2015)

Bottom Line: Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).The level of IL-32 expression could influence the N grade of CRC.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Floor 16, Building 2, 12 Wulumuqizhong Road, Shanghai, 200040, China. fengwu822@qq.com.

ABSTRACT

Background: Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.

Methods: Our study investigated whether IL-32 expression has clinical significance in the metastases of colorectal cancer (CRC). A total of 70 CRC patients were enrolled, 47 cases of which were single CRC organic metastasis lesions while the rest of which were primary CRC lesions (T4NxM0). IL-32 expression was detected by immunohistochemistry, and the correlation between IL-32 expression and CRC metastases was analyzed.

Results: The positive rates of IL-32 in the CRC organic metastasis group were more severe than those in the primary CRC group (P < 0.05). The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).

Conclusions: The level of IL-32 expression could influence the N grade of CRC. Thus, IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of CRC.

No MeSH data available.


Related in: MedlinePlus

IL-32 staining scored 0 (A); IL-32 staining scored 1+ (B); IL-32 staining scored 2+ (C); and IL-32 staining scored 3+ (D) magnification × 100.
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Fig1: IL-32 staining scored 0 (A); IL-32 staining scored 1+ (B); IL-32 staining scored 2+ (C); and IL-32 staining scored 3+ (D) magnification × 100.

Mentions: Immunohistochemistry (IHC) IL-32 expression pattern is described in Table 2: 22 cases score 0 (31.44%), 12 cases score 1+ (17.14%), 18 cases score 2+ (25.71%), and 18 cases score 3+ (25.71%). Figure 1 shows the comparison of the IHC slides for IL-32.Table 2


Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis.

Yang Y, Wang Z, Zhou Y, Wang X, Xiang J, Chen Z - World J Surg Oncol (2015)

IL-32 staining scored 0 (A); IL-32 staining scored 1+ (B); IL-32 staining scored 2+ (C); and IL-32 staining scored 3+ (D) magnification × 100.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4414001&req=5

Fig1: IL-32 staining scored 0 (A); IL-32 staining scored 1+ (B); IL-32 staining scored 2+ (C); and IL-32 staining scored 3+ (D) magnification × 100.
Mentions: Immunohistochemistry (IHC) IL-32 expression pattern is described in Table 2: 22 cases score 0 (31.44%), 12 cases score 1+ (17.14%), 18 cases score 2+ (25.71%), and 18 cases score 3+ (25.71%). Figure 1 shows the comparison of the IHC slides for IL-32.Table 2

Bottom Line: Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).The level of IL-32 expression could influence the N grade of CRC.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Floor 16, Building 2, 12 Wulumuqizhong Road, Shanghai, 200040, China. fengwu822@qq.com.

ABSTRACT

Background: Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.

Methods: Our study investigated whether IL-32 expression has clinical significance in the metastases of colorectal cancer (CRC). A total of 70 CRC patients were enrolled, 47 cases of which were single CRC organic metastasis lesions while the rest of which were primary CRC lesions (T4NxM0). IL-32 expression was detected by immunohistochemistry, and the correlation between IL-32 expression and CRC metastases was analyzed.

Results: The positive rates of IL-32 in the CRC organic metastasis group were more severe than those in the primary CRC group (P < 0.05). The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).

Conclusions: The level of IL-32 expression could influence the N grade of CRC. Thus, IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of CRC.

No MeSH data available.


Related in: MedlinePlus