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Usefulness of the controlled attenuation parameter for detecting liver steatosis in health checkup examinees.

Kim JK, Lee KS, Choi JR, Chung HJ, Jung da H, Lee KA, Lee JI - Gut Liver (2015)

Bottom Line: CAP values were correlated with body weight (r=0.404, p<0.001), body mass index (r=0.445, p<0.001), and the fatty liver grade by US (r=0.472, p<0.001).The CAP seems to be useful for detecting very low-grade hepatic steatosis in health checkup examinees.Its role in predicting subjects with a risk of metabolic derangement needs to be evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Background/aims: The controlled attenuation parameter (CAP) implemented in FibroScan® is reported to be a noninvasive means of detecting steatosis (>10% steatosis). We aimed to evaluate the usefulness of CAP in detecting steatosis among health checkup examinees and to assess its correlation with ultrasonography (US).

Methods: Consecutive CAP results were retrospectively collected. A total of 280 subjects were included.

Results: Fatty liver was detected in 119 subjects (42.5%) by US, whereas it was detected in 160 subjects (57.1%) by the CAP. The numbers of subjects with S0S1S2S3 steatosis according to the CAP value were 120595843, respectively. The mean CAP values were 203.34±28.39 dB/m for S0, 248.83±6.14 dB/m for S1, 274.33±8.53 dB/m for S2, and 322.35±22.20 dB/m for S3. CAP values were correlated with body weight (r=0.404, p<0.001), body mass index (r=0.445, p<0.001), and the fatty liver grade by US (r=0.472, p<0.001). Among the 161 subjects with normal US findings, steatosis was detected in 65 subjects (40.4%) using the CAP.

Conclusions: The CAP seems to be useful for detecting very low-grade hepatic steatosis in health checkup examinees. Its role in predicting subjects with a risk of metabolic derangement needs to be evaluated.

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Related in: MedlinePlus

Scatterplot and regression line showing a positive correlation between the grade of fatty change (0, normal; 1, mild; 2, moderate; and 3, severe) detected by ultrasonography and the controlled attenuation parameter in the checkup subjects.
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f1-gnl-09-405: Scatterplot and regression line showing a positive correlation between the grade of fatty change (0, normal; 1, mild; 2, moderate; and 3, severe) detected by ultrasonography and the controlled attenuation parameter in the checkup subjects.

Mentions: US identified fatty liver in 119 subjects (42.5%), while CAP measurement revealed S1-3 grade steatosis in 160 subjects (57.1%). By US, 65 subjects (54.6%) had mild fatty liver, 44 subjects (37.0%) had moderate fatty liver, and 10 subjects (8.4%) had severe fatty liver. By CAP value, subjects with S1, S2, and S3 grade steatosis were 59 (36.9%), 58 (36.2%) and 43 (26.9%), respectively. The mean values of CAP in S0, S1, S2, and S3 groups were 203.3±28.4 dB/m, 248.8±6.1 dB/m, 274.3±8.5 dB/m, and 322.4±22.2 dB/m, respectively (Table 2). Distribution of CAP was plotted by the degree of fatty change in US (Fig. 1).


Usefulness of the controlled attenuation parameter for detecting liver steatosis in health checkup examinees.

Kim JK, Lee KS, Choi JR, Chung HJ, Jung da H, Lee KA, Lee JI - Gut Liver (2015)

Scatterplot and regression line showing a positive correlation between the grade of fatty change (0, normal; 1, mild; 2, moderate; and 3, severe) detected by ultrasonography and the controlled attenuation parameter in the checkup subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4413975&req=5

f1-gnl-09-405: Scatterplot and regression line showing a positive correlation between the grade of fatty change (0, normal; 1, mild; 2, moderate; and 3, severe) detected by ultrasonography and the controlled attenuation parameter in the checkup subjects.
Mentions: US identified fatty liver in 119 subjects (42.5%), while CAP measurement revealed S1-3 grade steatosis in 160 subjects (57.1%). By US, 65 subjects (54.6%) had mild fatty liver, 44 subjects (37.0%) had moderate fatty liver, and 10 subjects (8.4%) had severe fatty liver. By CAP value, subjects with S1, S2, and S3 grade steatosis were 59 (36.9%), 58 (36.2%) and 43 (26.9%), respectively. The mean values of CAP in S0, S1, S2, and S3 groups were 203.3±28.4 dB/m, 248.8±6.1 dB/m, 274.3±8.5 dB/m, and 322.4±22.2 dB/m, respectively (Table 2). Distribution of CAP was plotted by the degree of fatty change in US (Fig. 1).

Bottom Line: CAP values were correlated with body weight (r=0.404, p<0.001), body mass index (r=0.445, p<0.001), and the fatty liver grade by US (r=0.472, p<0.001).The CAP seems to be useful for detecting very low-grade hepatic steatosis in health checkup examinees.Its role in predicting subjects with a risk of metabolic derangement needs to be evaluated.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Background/aims: The controlled attenuation parameter (CAP) implemented in FibroScan® is reported to be a noninvasive means of detecting steatosis (>10% steatosis). We aimed to evaluate the usefulness of CAP in detecting steatosis among health checkup examinees and to assess its correlation with ultrasonography (US).

Methods: Consecutive CAP results were retrospectively collected. A total of 280 subjects were included.

Results: Fatty liver was detected in 119 subjects (42.5%) by US, whereas it was detected in 160 subjects (57.1%) by the CAP. The numbers of subjects with S0S1S2S3 steatosis according to the CAP value were 120595843, respectively. The mean CAP values were 203.34±28.39 dB/m for S0, 248.83±6.14 dB/m for S1, 274.33±8.53 dB/m for S2, and 322.35±22.20 dB/m for S3. CAP values were correlated with body weight (r=0.404, p<0.001), body mass index (r=0.445, p<0.001), and the fatty liver grade by US (r=0.472, p<0.001). Among the 161 subjects with normal US findings, steatosis was detected in 65 subjects (40.4%) using the CAP.

Conclusions: The CAP seems to be useful for detecting very low-grade hepatic steatosis in health checkup examinees. Its role in predicting subjects with a risk of metabolic derangement needs to be evaluated.

Show MeSH
Related in: MedlinePlus