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Sonographic evaluation of gallbladder motility in children with chronic functional constipation.

Mehra R, Sodhi KS, Saxena A, Thapa BR, Khandelwal N - Gut Liver (2015)

Bottom Line: The mean value of the contractility index for the patients (15.77±24.68) was significantly lower than the mean value for the controls (43.66±11.58) (p=0.001).The mean postprandial gallbladder volumes and areas were larger in children with gallbladder hypomotility (p<0.05).This study contributes to the understanding of the underlying pathophysiology, which will enable advancement in and improved management of children with chronic constipation and associated gallbladder hypomotility.

View Article: PubMed Central - PubMed

Affiliation: Department of Radio Diagnosis, Institute of Medical Education and Research (PGIMER), Chandigarh, India.

ABSTRACT

Background/aims: Studies in adults suggest that constipation may not be a purely colonic pathology and may be a component of a generalized gastrointestinal (GI) motor disorder in which proximal GI motility can be impaired. Pediatric data are scarce, and the natural history of the disorder remains undefined. We aimed to evaluate gallbladder motility in a subset of Asian children with chronic functional constipation.

Methods: Abdominal ultrasound was performed on 105 children, including 55 patients (aged 3 to 13 years) with chronic functional constipation who met the inclusion criteria and 50 age- and gender-matched controls. The gallbladder contractility index was calculated based on the preprandial and postprandial gallbladder areas. Preprandial and postprandial values for gallbladder volume and wall thickness were evaluated.

Results: The mean value of the contractility index for the patients (15.77±24.68) was significantly lower than the mean value for the controls (43.66±11.58) (p=0.001). The mean postprandial gallbladder volumes and areas were larger in children with gallbladder hypomotility (p<0.05). The mean duration of constipation (4.8 months) was significantly higher (p=0.004) in the children with gallbladder hypomotility.

Conclusions: Gallbladder motility is significantly impaired in children with chronic functional constipation. This study contributes to the understanding of the underlying pathophysiology, which will enable advancement in and improved management of children with chronic constipation and associated gallbladder hypomotility.

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Related in: MedlinePlus

Ultrasound evaluation of gallbladder wall (anterior) thickness.
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f3-gnl-09-388: Ultrasound evaluation of gallbladder wall (anterior) thickness.

Mentions: Where L is the length, W is the width, and H is the height, or depth, of the gallbladder. The constant Π/6 reduces to 0.52 (Figs 1–3).


Sonographic evaluation of gallbladder motility in children with chronic functional constipation.

Mehra R, Sodhi KS, Saxena A, Thapa BR, Khandelwal N - Gut Liver (2015)

Ultrasound evaluation of gallbladder wall (anterior) thickness.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4413973&req=5

f3-gnl-09-388: Ultrasound evaluation of gallbladder wall (anterior) thickness.
Mentions: Where L is the length, W is the width, and H is the height, or depth, of the gallbladder. The constant Π/6 reduces to 0.52 (Figs 1–3).

Bottom Line: The mean value of the contractility index for the patients (15.77±24.68) was significantly lower than the mean value for the controls (43.66±11.58) (p=0.001).The mean postprandial gallbladder volumes and areas were larger in children with gallbladder hypomotility (p<0.05).This study contributes to the understanding of the underlying pathophysiology, which will enable advancement in and improved management of children with chronic constipation and associated gallbladder hypomotility.

View Article: PubMed Central - PubMed

Affiliation: Department of Radio Diagnosis, Institute of Medical Education and Research (PGIMER), Chandigarh, India.

ABSTRACT

Background/aims: Studies in adults suggest that constipation may not be a purely colonic pathology and may be a component of a generalized gastrointestinal (GI) motor disorder in which proximal GI motility can be impaired. Pediatric data are scarce, and the natural history of the disorder remains undefined. We aimed to evaluate gallbladder motility in a subset of Asian children with chronic functional constipation.

Methods: Abdominal ultrasound was performed on 105 children, including 55 patients (aged 3 to 13 years) with chronic functional constipation who met the inclusion criteria and 50 age- and gender-matched controls. The gallbladder contractility index was calculated based on the preprandial and postprandial gallbladder areas. Preprandial and postprandial values for gallbladder volume and wall thickness were evaluated.

Results: The mean value of the contractility index for the patients (15.77±24.68) was significantly lower than the mean value for the controls (43.66±11.58) (p=0.001). The mean postprandial gallbladder volumes and areas were larger in children with gallbladder hypomotility (p<0.05). The mean duration of constipation (4.8 months) was significantly higher (p=0.004) in the children with gallbladder hypomotility.

Conclusions: Gallbladder motility is significantly impaired in children with chronic functional constipation. This study contributes to the understanding of the underlying pathophysiology, which will enable advancement in and improved management of children with chronic constipation and associated gallbladder hypomotility.

Show MeSH
Related in: MedlinePlus