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Virtual Touch tissue quantification cannot assess breast cancer lesions except for ductal carcinomas in situ and small invasive cancers: a retrospective study.

Tada K, Nishioka K, Kikuchi Y, Niwa T, Seto Y - World J Surg Oncol (2015)

Bottom Line: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue.To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.Seventy-six percent of the malignant lesions could not be assessed using VTTQ.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast and Endocrine Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. ktada-tky@umin.ac.jp.

ABSTRACT

Background: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue. However, the clinical impact of this device on the assessment of breast cancer is unclear.

Methods: This study aimed to review the ultrasound records of patients with breast lesions where VTTQ was used to assess 123 normal breast tissues, 18 benign tumors, and 117 histopathologically confirmed breast cancers in a total of 129 patients. To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.

Results: Seventy-six percent of the malignant lesions could not be assessed using VTTQ. Among the malignant lesions, ductal carcinomas in situ (DCIS) and invasive breast cancers smaller than 1.6 cm tended to be 'measurable.' Only 17 and 1% of benign breast lesions and areas of normal breast tissue, respectively, were considered to be 'unmeasurable' (P<0.001).

Conclusions: A breast lesion that could not be quantitatively assessed by VTTQ was suspicious for malignancy. By contrast, DCIS lesions and small invasive breast cancers tended to be 'measurable.' These findings indicate that VTTQ may be a useful application for assessing breast tumors.

No MeSH data available.


Related in: MedlinePlus

Box-and-whisker plot of Virtual Touch tissue quantification of the region of interest in normal breast, benign breast lesions, and malignant lesions. There was a significant difference between the velocity of the shear waves produced by these three types of lesions according to nonparametric analysis. However, there was no significant difference between benign and malignant lesions. The horizontal line in the box indicates the median of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of these samples.
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Fig4: Box-and-whisker plot of Virtual Touch tissue quantification of the region of interest in normal breast, benign breast lesions, and malignant lesions. There was a significant difference between the velocity of the shear waves produced by these three types of lesions according to nonparametric analysis. However, there was no significant difference between benign and malignant lesions. The horizontal line in the box indicates the median of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of these samples.

Mentions: Figure 4 shows the distribution of mean VTTQ values of measureable normal breast tissues, benign lesions, and malignant lesions. The degree of elasticity decreased from normal to benign to malignant lesions. Nonparametric analysis found a significant difference between the three types of tissues measured (P < 0.001). However, the difference between benign and malignant lesions was not significant (P = 0.534).Figure 4


Virtual Touch tissue quantification cannot assess breast cancer lesions except for ductal carcinomas in situ and small invasive cancers: a retrospective study.

Tada K, Nishioka K, Kikuchi Y, Niwa T, Seto Y - World J Surg Oncol (2015)

Box-and-whisker plot of Virtual Touch tissue quantification of the region of interest in normal breast, benign breast lesions, and malignant lesions. There was a significant difference between the velocity of the shear waves produced by these three types of lesions according to nonparametric analysis. However, there was no significant difference between benign and malignant lesions. The horizontal line in the box indicates the median of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of these samples.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4404122&req=5

Fig4: Box-and-whisker plot of Virtual Touch tissue quantification of the region of interest in normal breast, benign breast lesions, and malignant lesions. There was a significant difference between the velocity of the shear waves produced by these three types of lesions according to nonparametric analysis. However, there was no significant difference between benign and malignant lesions. The horizontal line in the box indicates the median of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of these samples.
Mentions: Figure 4 shows the distribution of mean VTTQ values of measureable normal breast tissues, benign lesions, and malignant lesions. The degree of elasticity decreased from normal to benign to malignant lesions. Nonparametric analysis found a significant difference between the three types of tissues measured (P < 0.001). However, the difference between benign and malignant lesions was not significant (P = 0.534).Figure 4

Bottom Line: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue.To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.Seventy-six percent of the malignant lesions could not be assessed using VTTQ.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast and Endocrine Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. ktada-tky@umin.ac.jp.

ABSTRACT

Background: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue. However, the clinical impact of this device on the assessment of breast cancer is unclear.

Methods: This study aimed to review the ultrasound records of patients with breast lesions where VTTQ was used to assess 123 normal breast tissues, 18 benign tumors, and 117 histopathologically confirmed breast cancers in a total of 129 patients. To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.

Results: Seventy-six percent of the malignant lesions could not be assessed using VTTQ. Among the malignant lesions, ductal carcinomas in situ (DCIS) and invasive breast cancers smaller than 1.6 cm tended to be 'measurable.' Only 17 and 1% of benign breast lesions and areas of normal breast tissue, respectively, were considered to be 'unmeasurable' (P<0.001).

Conclusions: A breast lesion that could not be quantitatively assessed by VTTQ was suspicious for malignancy. By contrast, DCIS lesions and small invasive breast cancers tended to be 'measurable.' These findings indicate that VTTQ may be a useful application for assessing breast tumors.

No MeSH data available.


Related in: MedlinePlus