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Virtual Touch tissue quantification cannot assess breast cancer lesions except for ductal carcinomas in situ and small invasive cancers: a retrospective study.

Tada K, Nishioka K, Kikuchi Y, Niwa T, Seto Y - World J Surg Oncol (2015)

Bottom Line: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue.To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.Seventy-six percent of the malignant lesions could not be assessed using VTTQ.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast and Endocrine Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. ktada-tky@umin.ac.jp.

ABSTRACT

Background: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue. However, the clinical impact of this device on the assessment of breast cancer is unclear.

Methods: This study aimed to review the ultrasound records of patients with breast lesions where VTTQ was used to assess 123 normal breast tissues, 18 benign tumors, and 117 histopathologically confirmed breast cancers in a total of 129 patients. To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.

Results: Seventy-six percent of the malignant lesions could not be assessed using VTTQ. Among the malignant lesions, ductal carcinomas in situ (DCIS) and invasive breast cancers smaller than 1.6 cm tended to be 'measurable.' Only 17 and 1% of benign breast lesions and areas of normal breast tissue, respectively, were considered to be 'unmeasurable' (P<0.001).

Conclusions: A breast lesion that could not be quantitatively assessed by VTTQ was suspicious for malignancy. By contrast, DCIS lesions and small invasive breast cancers tended to be 'measurable.' These findings indicate that VTTQ may be a useful application for assessing breast tumors.

No MeSH data available.


Related in: MedlinePlus

Box-and-whisker plots of breast lesion sizes according to whether lesions were measurable or unmeasurable by Virtual Touch tissue quantification. Nonparametric analysis found a significant difference in the sizes of measureable versus unmeasureable lesions. The horizontal line in the box indicates the median size of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of the samples.
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Fig2: Box-and-whisker plots of breast lesion sizes according to whether lesions were measurable or unmeasurable by Virtual Touch tissue quantification. Nonparametric analysis found a significant difference in the sizes of measureable versus unmeasureable lesions. The horizontal line in the box indicates the median size of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of the samples.

Mentions: Figure 2 shows the relationship between tumor size and measurability for lesions of invasive breast cancer. Smaller lesions of invasive breast cancer were more likely to be measurable (Mann-Whitney test, P = 0.002). Figure 3 shows the ROC curve of lesion size and measurability. The Youden index was 1.6 cm, which was the estimate for the cutoff value for the size of tumors assessable using VTTQ.Figure 2


Virtual Touch tissue quantification cannot assess breast cancer lesions except for ductal carcinomas in situ and small invasive cancers: a retrospective study.

Tada K, Nishioka K, Kikuchi Y, Niwa T, Seto Y - World J Surg Oncol (2015)

Box-and-whisker plots of breast lesion sizes according to whether lesions were measurable or unmeasurable by Virtual Touch tissue quantification. Nonparametric analysis found a significant difference in the sizes of measureable versus unmeasureable lesions. The horizontal line in the box indicates the median size of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of the samples.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4404122&req=5

Fig2: Box-and-whisker plots of breast lesion sizes according to whether lesions were measurable or unmeasurable by Virtual Touch tissue quantification. Nonparametric analysis found a significant difference in the sizes of measureable versus unmeasureable lesions. The horizontal line in the box indicates the median size of the samples. The upper and lower sides of the box represent the 75th and 25th percentiles, respectively. The upper and lower sides of the whiskers represent the 90th and 10th percentiles, respectively. ‘M’ is the mean value of the samples.
Mentions: Figure 2 shows the relationship between tumor size and measurability for lesions of invasive breast cancer. Smaller lesions of invasive breast cancer were more likely to be measurable (Mann-Whitney test, P = 0.002). Figure 3 shows the ROC curve of lesion size and measurability. The Youden index was 1.6 cm, which was the estimate for the cutoff value for the size of tumors assessable using VTTQ.Figure 2

Bottom Line: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue.To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.Seventy-six percent of the malignant lesions could not be assessed using VTTQ.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast and Endocrine Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. ktada-tky@umin.ac.jp.

ABSTRACT

Background: Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue. However, the clinical impact of this device on the assessment of breast cancer is unclear.

Methods: This study aimed to review the ultrasound records of patients with breast lesions where VTTQ was used to assess 123 normal breast tissues, 18 benign tumors, and 117 histopathologically confirmed breast cancers in a total of 129 patients. To determine the VTTQ value, a 5×5 mm region of interest was placed in the center of the area of interest, and the target lesion was measured at least three times by VTTQ.

Results: Seventy-six percent of the malignant lesions could not be assessed using VTTQ. Among the malignant lesions, ductal carcinomas in situ (DCIS) and invasive breast cancers smaller than 1.6 cm tended to be 'measurable.' Only 17 and 1% of benign breast lesions and areas of normal breast tissue, respectively, were considered to be 'unmeasurable' (P<0.001).

Conclusions: A breast lesion that could not be quantitatively assessed by VTTQ was suspicious for malignancy. By contrast, DCIS lesions and small invasive breast cancers tended to be 'measurable.' These findings indicate that VTTQ may be a useful application for assessing breast tumors.

No MeSH data available.


Related in: MedlinePlus