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Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human.

Wang Q, Zhang M, Xu M, Gu W, Xi Y, Qi L, Li B, Wang W - PLoS ONE (2015)

Bottom Line: We found that the prevalence of BAT was around 2.7% in our study participants, with a significant sexual difference (5.5% in the females vs. 1.3% in the males; p<0.0001).The BAT positive subjects had lower BMI (P<0.0001), less SFA (P<0.01), VFA (P<0.0001), WC (P<0.0001), lower fasting glucose and triglyceride levels (both P<0.01) and increased HDL cholesterol concentrations (P<0.0001), compared with the BAT negative subjects.Our data suggest that decreased amount of active BAT might be associated with accumulation of visceral fat content and unfavorable metabolic outcomes.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.

ABSTRACT

Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity. However, the supporting evidence on the relationship between BAT and central obesity and metabolic profile in large population based studies is sparse.

Methodology/principal findings: We studied 4011 (2688 males and 1323 females) tumor-free Chinese adults aged 18-89 for BAT activities, visceral/subcutaneous fat areas (VFA/SFA), waist circumferences (WC) and metabolic parameters. We found that the prevalence of BAT was around 2.7% in our study participants, with a significant sexual difference (5.5% in the females vs. 1.3% in the males; p<0.0001). BAT detection was increased in low temperature and declined in elderly subjects. The BAT positive subjects had lower BMI (P<0.0001), less SFA (P<0.01), VFA (P<0.0001), WC (P<0.0001), lower fasting glucose and triglyceride levels (both P<0.01) and increased HDL cholesterol concentrations (P<0.0001), compared with the BAT negative subjects. Robust logistic regression revealed that after adjustment for covariates (including age, sex, BMI, VFA, SFA and WC), age and BMI in the males (0.92 [95%CI, 0.88-0.96] and 0.84 [95% CI, 0.75-0.96], both P ≤0.008) while age and VFA in the females (0.87 [95%CI, 0.83-0.91] and 0.98 [95%CI, 0.97-0.99], respectively, P<0.05) were independently associated with detectable BAT.

Conclusions/significance: Our data suggest that decreased amount of active BAT might be associated with accumulation of visceral fat content and unfavorable metabolic outcomes.

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Related in: MedlinePlus

Correlation between the prevalence of badipose tissue and temperature, age and gender.Panel A shows the prevalence of detectable BAT in men and women. Panel B shows the percentage of patients in different age ranges that had detectable BAT. In panel C, for the patients with detectable BAT, the activity of BAT in grams times the mean standardized uptake value (SUV) in grams per milliliter was shown in each month during a 3 year period from May 2007-Feb 2010. In Panel D, outdoor temperatures in Shanghai for the dates of scans were obtained and the percentage of subjects with detectable BAT in different temperature ranges was determined. A univariate analysis was used to assess the significance of differences in the percentages with the use of a chi-square test.
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pone.0123795.g001: Correlation between the prevalence of badipose tissue and temperature, age and gender.Panel A shows the prevalence of detectable BAT in men and women. Panel B shows the percentage of patients in different age ranges that had detectable BAT. In panel C, for the patients with detectable BAT, the activity of BAT in grams times the mean standardized uptake value (SUV) in grams per milliliter was shown in each month during a 3 year period from May 2007-Feb 2010. In Panel D, outdoor temperatures in Shanghai for the dates of scans were obtained and the percentage of subjects with detectable BAT in different temperature ranges was determined. A univariate analysis was used to assess the significance of differences in the percentages with the use of a chi-square test.

Mentions: The prevalence of BAT was significantly higher in female than that in male subjects (5.52% vs. 1.34%, P < 0.0001, table 1, Fig 1A). The detection rate of BAT was 13.43%, 4.11%, 0.27% and 0% in subjects less than 30, 30–50, 50–70 and more than 70 years old, respectively (Fig 1B). The average age was significantly lower in BAT positive subjects both in the male and the female subjects (Table 2). The probability of the detection of BAT presented seasonal variation (Fig 1C), i.e. being lowest for subjects measured in summer (0.18%, June-August), moderate in spring (2.71%, March-May) and autumn (2.11%, September-November) and highest in winter (6.93%, December-February, P<0.001). It has been reported that a relative low temperature at 19–21°C may be more appropriate to detect BAT [12,26]. Indeed, the prevalence of BAT was significantly higher when outdoor temperature was below than above 20°C (5.00% vs. 0.45%, P < 0.0001, Fig 1D). Moreover, mean outdoor temperature was significantly lower in subjects bearing detectable BAT in both the males and the females (P<0.0001, Table 2)


Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human.

Wang Q, Zhang M, Xu M, Gu W, Xi Y, Qi L, Li B, Wang W - PLoS ONE (2015)

Correlation between the prevalence of badipose tissue and temperature, age and gender.Panel A shows the prevalence of detectable BAT in men and women. Panel B shows the percentage of patients in different age ranges that had detectable BAT. In panel C, for the patients with detectable BAT, the activity of BAT in grams times the mean standardized uptake value (SUV) in grams per milliliter was shown in each month during a 3 year period from May 2007-Feb 2010. In Panel D, outdoor temperatures in Shanghai for the dates of scans were obtained and the percentage of subjects with detectable BAT in different temperature ranges was determined. A univariate analysis was used to assess the significance of differences in the percentages with the use of a chi-square test.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403996&req=5

pone.0123795.g001: Correlation between the prevalence of badipose tissue and temperature, age and gender.Panel A shows the prevalence of detectable BAT in men and women. Panel B shows the percentage of patients in different age ranges that had detectable BAT. In panel C, for the patients with detectable BAT, the activity of BAT in grams times the mean standardized uptake value (SUV) in grams per milliliter was shown in each month during a 3 year period from May 2007-Feb 2010. In Panel D, outdoor temperatures in Shanghai for the dates of scans were obtained and the percentage of subjects with detectable BAT in different temperature ranges was determined. A univariate analysis was used to assess the significance of differences in the percentages with the use of a chi-square test.
Mentions: The prevalence of BAT was significantly higher in female than that in male subjects (5.52% vs. 1.34%, P < 0.0001, table 1, Fig 1A). The detection rate of BAT was 13.43%, 4.11%, 0.27% and 0% in subjects less than 30, 30–50, 50–70 and more than 70 years old, respectively (Fig 1B). The average age was significantly lower in BAT positive subjects both in the male and the female subjects (Table 2). The probability of the detection of BAT presented seasonal variation (Fig 1C), i.e. being lowest for subjects measured in summer (0.18%, June-August), moderate in spring (2.71%, March-May) and autumn (2.11%, September-November) and highest in winter (6.93%, December-February, P<0.001). It has been reported that a relative low temperature at 19–21°C may be more appropriate to detect BAT [12,26]. Indeed, the prevalence of BAT was significantly higher when outdoor temperature was below than above 20°C (5.00% vs. 0.45%, P < 0.0001, Fig 1D). Moreover, mean outdoor temperature was significantly lower in subjects bearing detectable BAT in both the males and the females (P<0.0001, Table 2)

Bottom Line: We found that the prevalence of BAT was around 2.7% in our study participants, with a significant sexual difference (5.5% in the females vs. 1.3% in the males; p<0.0001).The BAT positive subjects had lower BMI (P<0.0001), less SFA (P<0.01), VFA (P<0.0001), WC (P<0.0001), lower fasting glucose and triglyceride levels (both P<0.01) and increased HDL cholesterol concentrations (P<0.0001), compared with the BAT negative subjects.Our data suggest that decreased amount of active BAT might be associated with accumulation of visceral fat content and unfavorable metabolic outcomes.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.

ABSTRACT

Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity. However, the supporting evidence on the relationship between BAT and central obesity and metabolic profile in large population based studies is sparse.

Methodology/principal findings: We studied 4011 (2688 males and 1323 females) tumor-free Chinese adults aged 18-89 for BAT activities, visceral/subcutaneous fat areas (VFA/SFA), waist circumferences (WC) and metabolic parameters. We found that the prevalence of BAT was around 2.7% in our study participants, with a significant sexual difference (5.5% in the females vs. 1.3% in the males; p<0.0001). BAT detection was increased in low temperature and declined in elderly subjects. The BAT positive subjects had lower BMI (P<0.0001), less SFA (P<0.01), VFA (P<0.0001), WC (P<0.0001), lower fasting glucose and triglyceride levels (both P<0.01) and increased HDL cholesterol concentrations (P<0.0001), compared with the BAT negative subjects. Robust logistic regression revealed that after adjustment for covariates (including age, sex, BMI, VFA, SFA and WC), age and BMI in the males (0.92 [95%CI, 0.88-0.96] and 0.84 [95% CI, 0.75-0.96], both P ≤0.008) while age and VFA in the females (0.87 [95%CI, 0.83-0.91] and 0.98 [95%CI, 0.97-0.99], respectively, P<0.05) were independently associated with detectable BAT.

Conclusions/significance: Our data suggest that decreased amount of active BAT might be associated with accumulation of visceral fat content and unfavorable metabolic outcomes.

Show MeSH
Related in: MedlinePlus