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Extracorporeal photopheresis for graft-versus-host disease: the role of patient, transplant, and classification criteria and hematologic values on outcome-results from a large single-center study.

Berger M, Albiani R, Sini B, Fagioli F - Transfusion (2014)

Bottom Line: The aGVHD-free survival was associated with aGVHD grading (Grade II 81%, Grade III 33%, and Grade IV 0%, p ≤ 0.00) and the absence of visceral involvement (77% vs. 33%, p = 0.03).The cGVHD-free survival was associated with the female sex (67% vs. 25%, p = 0.01) and with the limited form according to the Seattle classification (67% vs. 20%, p = 0.003).No role for hematologic values or apheresis cell count was found, except for the cGVHD ORR (p = 0.037).

View Article: PubMed Central - PubMed

Affiliation: Pediatric Onco-Hematology and Stem Cell Transplant Division, Regina Margherita Children's Hospital, Turin, Italy.

No MeSH data available.


Related in: MedlinePlus

aGVHD-free survival, TRM, and RI for patients who underwent ECP for aGVHD.
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fig01: aGVHD-free survival, TRM, and RI for patients who underwent ECP for aGVHD.

Mentions: For all patients the aGVHD-free survival was 50% (95% confidence interval [CI], 34%-73%; Fig. 1). In univariate analysis the aGVHD grades were significantly associated with different outcomes: Grade II had 81% (95% CI, 64%-100%), Grade III aGVHD had 33% (95% CI, 15%-74%), and Grade IV aGVHD had 0% (p < 0.0008). When we considered the collected TNCs or lymphocytes or the hematologic values before ECP the probability of aGVHD-free survival did not differ even when the patients were stratified according to quartiles (data not reported). The multivariate analysis showed how only the GVHD grade was the sole independent factor with relative risk (RR) of 3.37 (95% CI, 2.44-5.07, p = 0.0015).


Extracorporeal photopheresis for graft-versus-host disease: the role of patient, transplant, and classification criteria and hematologic values on outcome-results from a large single-center study.

Berger M, Albiani R, Sini B, Fagioli F - Transfusion (2014)

aGVHD-free survival, TRM, and RI for patients who underwent ECP for aGVHD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403977&req=5

fig01: aGVHD-free survival, TRM, and RI for patients who underwent ECP for aGVHD.
Mentions: For all patients the aGVHD-free survival was 50% (95% confidence interval [CI], 34%-73%; Fig. 1). In univariate analysis the aGVHD grades were significantly associated with different outcomes: Grade II had 81% (95% CI, 64%-100%), Grade III aGVHD had 33% (95% CI, 15%-74%), and Grade IV aGVHD had 0% (p < 0.0008). When we considered the collected TNCs or lymphocytes or the hematologic values before ECP the probability of aGVHD-free survival did not differ even when the patients were stratified according to quartiles (data not reported). The multivariate analysis showed how only the GVHD grade was the sole independent factor with relative risk (RR) of 3.37 (95% CI, 2.44-5.07, p = 0.0015).

Bottom Line: The aGVHD-free survival was associated with aGVHD grading (Grade II 81%, Grade III 33%, and Grade IV 0%, p ≤ 0.00) and the absence of visceral involvement (77% vs. 33%, p = 0.03).The cGVHD-free survival was associated with the female sex (67% vs. 25%, p = 0.01) and with the limited form according to the Seattle classification (67% vs. 20%, p = 0.003).No role for hematologic values or apheresis cell count was found, except for the cGVHD ORR (p = 0.037).

View Article: PubMed Central - PubMed

Affiliation: Pediatric Onco-Hematology and Stem Cell Transplant Division, Regina Margherita Children's Hospital, Turin, Italy.

No MeSH data available.


Related in: MedlinePlus