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Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.

Grech-Sollars M, Hales PW, Miyazaki K, Raschke F, Rodriguez D, Wilson M, Gill SK, Banks T, Saunders DE, Clayden JD, Gwilliam MN, Barrick TR, Morgan PS, Davies NP, Rossiter J, Auer DP, Grundy R, Leach MO, Howe FA, Peet AC, Clark CA - NMR Biomed (2015)

Bottom Line: A mixed effect model was used to measure the intra- and inter-scanner coefficient of variation (CV) for each of the five parameters.No major difference in the inter-scanner CV for ADC, D, MD and FA was observed when analysing the 1.5T and 3T scanners separately.ADC, D, MD and FA all showed good intra-scanner reproducibility, with the inter-scanner reproducibility being comparable or faring slightly worse, suggesting that using data from multiple scanners does not have an adverse effect compared with using data from the same scanner.

View Article: PubMed Central - PubMed

Affiliation: Developmental Imaging and Biophysics Section, UCL Institute of Child Health, University College London, London, UK.

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Inter- and intra-scanner CV in volunteers. The graph shows the inter- and intra-scanner CV for all parameters in overall grey matter (GM) and overall white matter (WM), together with the mean values for each of the parameters. The inter-scanner CV was less than 4% for all parameters except for the perfusion fraction. The higher intra-scanner CV for FA in grey matter is likely to be due to an increased noise effect on FA values closer to zero, driving the intra-scanner variation up.
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fig06: Inter- and intra-scanner CV in volunteers. The graph shows the inter- and intra-scanner CV for all parameters in overall grey matter (GM) and overall white matter (WM), together with the mean values for each of the parameters. The inter-scanner CV was less than 4% for all parameters except for the perfusion fraction. The higher intra-scanner CV for FA in grey matter is likely to be due to an increased noise effect on FA values closer to zero, driving the intra-scanner variation up.

Mentions: Box plots showing the range of values observed in all volunteers across all scanners are shown for grey matter in Figure4 and for white matter in Figure5. Results for reproducibility of ADC, D, f, MD and FA in grey matter and white matter (depicted in Figure6) and the eight brain regions for volunteer scans are given in Tables4–8 respectively. The tables show the mean, standard deviation and CV results from the mixed-effect model describing the variation expected if the same volunteer is scanned on a different scanner (inter-scanner reproducibility), if a different volunteer is scanned on the same scanner (inter-volunteer) and if the same volunteer is scanned on the same scanner (intra-scanner reproducibility).


Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.

Grech-Sollars M, Hales PW, Miyazaki K, Raschke F, Rodriguez D, Wilson M, Gill SK, Banks T, Saunders DE, Clayden JD, Gwilliam MN, Barrick TR, Morgan PS, Davies NP, Rossiter J, Auer DP, Grundy R, Leach MO, Howe FA, Peet AC, Clark CA - NMR Biomed (2015)

Inter- and intra-scanner CV in volunteers. The graph shows the inter- and intra-scanner CV for all parameters in overall grey matter (GM) and overall white matter (WM), together with the mean values for each of the parameters. The inter-scanner CV was less than 4% for all parameters except for the perfusion fraction. The higher intra-scanner CV for FA in grey matter is likely to be due to an increased noise effect on FA values closer to zero, driving the intra-scanner variation up.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403968&req=5

fig06: Inter- and intra-scanner CV in volunteers. The graph shows the inter- and intra-scanner CV for all parameters in overall grey matter (GM) and overall white matter (WM), together with the mean values for each of the parameters. The inter-scanner CV was less than 4% for all parameters except for the perfusion fraction. The higher intra-scanner CV for FA in grey matter is likely to be due to an increased noise effect on FA values closer to zero, driving the intra-scanner variation up.
Mentions: Box plots showing the range of values observed in all volunteers across all scanners are shown for grey matter in Figure4 and for white matter in Figure5. Results for reproducibility of ADC, D, f, MD and FA in grey matter and white matter (depicted in Figure6) and the eight brain regions for volunteer scans are given in Tables4–8 respectively. The tables show the mean, standard deviation and CV results from the mixed-effect model describing the variation expected if the same volunteer is scanned on a different scanner (inter-scanner reproducibility), if a different volunteer is scanned on the same scanner (inter-volunteer) and if the same volunteer is scanned on the same scanner (intra-scanner reproducibility).

Bottom Line: A mixed effect model was used to measure the intra- and inter-scanner coefficient of variation (CV) for each of the five parameters.No major difference in the inter-scanner CV for ADC, D, MD and FA was observed when analysing the 1.5T and 3T scanners separately.ADC, D, MD and FA all showed good intra-scanner reproducibility, with the inter-scanner reproducibility being comparable or faring slightly worse, suggesting that using data from multiple scanners does not have an adverse effect compared with using data from the same scanner.

View Article: PubMed Central - PubMed

Affiliation: Developmental Imaging and Biophysics Section, UCL Institute of Child Health, University College London, London, UK.

Show MeSH
Related in: MedlinePlus