Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.
Bottom Line: A mixed effect model was used to measure the intra- and inter-scanner coefficient of variation (CV) for each of the five parameters.No major difference in the inter-scanner CV for ADC, D, MD and FA was observed when analysing the 1.5T and 3T scanners separately.ADC, D, MD and FA all showed good intra-scanner reproducibility, with the inter-scanner reproducibility being comparable or faring slightly worse, suggesting that using data from multiple scanners does not have an adverse effect compared with using data from the same scanner.
Affiliation: Developmental Imaging and Biophysics Section, UCL Institute of Child Health, University College London, London, UK.Show MeSH
Related in: MedlinePlus
Mentions: Box plots showing the range of values observed in all volunteers across all scanners are shown for grey matter in Figure4 and for white matter in Figure5. Results for reproducibility of ADC, D, f, MD and FA in grey matter and white matter (depicted in Figure6) and the eight brain regions for volunteer scans are given in Tables4–8 respectively. The tables show the mean, standard deviation and CV results from the mixed-effect model describing the variation expected if the same volunteer is scanned on a different scanner (inter-scanner reproducibility), if a different volunteer is scanned on the same scanner (inter-volunteer) and if the same volunteer is scanned on the same scanner (intra-scanner reproducibility).
Affiliation: Developmental Imaging and Biophysics Section, UCL Institute of Child Health, University College London, London, UK.