Limits...
CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations.

Rohde G, Message SD, Haas JJ, Kebadze T, Parker H, Laza-Stanca V, Khaitov MR, Kon OM, Stanciu LA, Mallia P, Edwards MR, Johnston SL - Clin. Exp. Allergy (2014)

Bottom Line: BAL HNP 1-3 and Elafin were higher, CXCL7/NAP-2 was lower in asthmatics compared with controls at day 4 (P = 0.035, P = 0.048, and P = 0.025, respectively).BAL HNP 1-3 and CXCL8/IL-8 were increased during infection (P = 0.003 and P = 0.011, respectively).Strategies to inhibit CXCL8/IL-8 may be useful in treatment of virus-induced asthma exacerbations.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma & Centre for Respiratory Infection, Imperial College London, London, UK; Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Show MeSH

Related in: MedlinePlus

(a) The relationship between bronchoalveolar lavage (BAL) HNP 1–3 levels and BAL viral load at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between HNP 1–3 and BAL viral load at day 4 post-infection, which was not present in the normal group (□). (b) The relationship between BAL HNP 1–3 levels and BAL neutrophils at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant correlation between HNP 1–3 and BAL neutrophils at day 4 post-infection. The same relationship was observed in the normal group (□). (c) The relationship between BAL elafin levels at day 4 post-infection and peak flow maximal fall was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between BAL elafin and peak flow maximal fall at day 4 post-infection, which was not present in the normal group (□).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4403958&req=5

fig02: (a) The relationship between bronchoalveolar lavage (BAL) HNP 1–3 levels and BAL viral load at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between HNP 1–3 and BAL viral load at day 4 post-infection, which was not present in the normal group (□). (b) The relationship between BAL HNP 1–3 levels and BAL neutrophils at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant correlation between HNP 1–3 and BAL neutrophils at day 4 post-infection. The same relationship was observed in the normal group (□). (c) The relationship between BAL elafin levels at day 4 post-infection and peak flow maximal fall was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between BAL elafin and peak flow maximal fall at day 4 post-infection, which was not present in the normal group (□).

Mentions: BAL HNP 1–3 measured at baseline was negatively correlated with BAL viral load (r = −0.880, P = 0.049) in asthmatics only (Fig.2a). BAL viral load was available in 5 asthmatic subjects only. Unfortunately, the other 5 samples got lost during a liquid nitrogen thawing over Christmas/New Year and were not available for analysis. BAL HNP 1–3 at baseline was correlated with BAL CXCL8/IL-8 at baseline in asthmatics only (r = 0.753, P = 0.031). BAL HNP 1–3 was the only parameter to be positively correlated with relative BAL neutrophil numbers at day 4 post-infection (in all subjects; Fig.2b). At week 6, BAL HNP 1–3 was also correlated with BAL CXCL8/IL-8 (r = 0.469, P = 0.028) in all subjects.


CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations.

Rohde G, Message SD, Haas JJ, Kebadze T, Parker H, Laza-Stanca V, Khaitov MR, Kon OM, Stanciu LA, Mallia P, Edwards MR, Johnston SL - Clin. Exp. Allergy (2014)

(a) The relationship between bronchoalveolar lavage (BAL) HNP 1–3 levels and BAL viral load at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between HNP 1–3 and BAL viral load at day 4 post-infection, which was not present in the normal group (□). (b) The relationship between BAL HNP 1–3 levels and BAL neutrophils at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant correlation between HNP 1–3 and BAL neutrophils at day 4 post-infection. The same relationship was observed in the normal group (□). (c) The relationship between BAL elafin levels at day 4 post-infection and peak flow maximal fall was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between BAL elafin and peak flow maximal fall at day 4 post-infection, which was not present in the normal group (□).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403958&req=5

fig02: (a) The relationship between bronchoalveolar lavage (BAL) HNP 1–3 levels and BAL viral load at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between HNP 1–3 and BAL viral load at day 4 post-infection, which was not present in the normal group (□). (b) The relationship between BAL HNP 1–3 levels and BAL neutrophils at day 4 post-infection was investigated in the two subject groups. In the asthmatic group (▪), there was a significant correlation between HNP 1–3 and BAL neutrophils at day 4 post-infection. The same relationship was observed in the normal group (□). (c) The relationship between BAL elafin levels at day 4 post-infection and peak flow maximal fall was investigated in the two subject groups. In the asthmatic group (▪), there was a significant inverse correlation between BAL elafin and peak flow maximal fall at day 4 post-infection, which was not present in the normal group (□).
Mentions: BAL HNP 1–3 measured at baseline was negatively correlated with BAL viral load (r = −0.880, P = 0.049) in asthmatics only (Fig.2a). BAL viral load was available in 5 asthmatic subjects only. Unfortunately, the other 5 samples got lost during a liquid nitrogen thawing over Christmas/New Year and were not available for analysis. BAL HNP 1–3 at baseline was correlated with BAL CXCL8/IL-8 at baseline in asthmatics only (r = 0.753, P = 0.031). BAL HNP 1–3 was the only parameter to be positively correlated with relative BAL neutrophil numbers at day 4 post-infection (in all subjects; Fig.2b). At week 6, BAL HNP 1–3 was also correlated with BAL CXCL8/IL-8 (r = 0.469, P = 0.028) in all subjects.

Bottom Line: BAL HNP 1-3 and Elafin were higher, CXCL7/NAP-2 was lower in asthmatics compared with controls at day 4 (P = 0.035, P = 0.048, and P = 0.025, respectively).BAL HNP 1-3 and CXCL8/IL-8 were increased during infection (P = 0.003 and P = 0.011, respectively).Strategies to inhibit CXCL8/IL-8 may be useful in treatment of virus-induced asthma exacerbations.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma & Centre for Respiratory Infection, Imperial College London, London, UK; Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Show MeSH
Related in: MedlinePlus