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Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors.

Liu JH, Tian SF, Ju Y, Li Y, Chen AL, Chen LH, Liu AL - BMC Cancer (2015)

Bottom Line: Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues.ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 222, Xigang District, Dalian, 116011, P. R China. liujinghong704@126.com.

ABSTRACT

Background: To determine the clinical value of apparent diffusion coefficient (ADC) measurement by diffusion weighted magnetic resonance imaging (DW-MRI) in differentiating renal tumors.

Methods: Electronic databases were searched using combinations of keywords and free words relating to renal tumor, ADC and DW-MRI. Based on carefully selected inclusion and exclusion criteria, relevant case-control studies were identified and the related clinical data was acquired. Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).

Results: Sixteen case-control studies were ultimately included in the present meta-analysis. These 16 high quality studies contained a combined total of 438 normal renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues. ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

Conclusions: ADC measurement by DW-MRI provided clinically useful information on the internal structure of renal tumors and could be an important radiographic index for differentiation of malignant renal tumors from benign renal tumors.

No MeSH data available.


Related in: MedlinePlus

Sensitivity analyses and funnel plots of apparent diffusion coefficient values of diffusion-weighted magnetic resonance imaging in differentiation of renal tumors (A: Sensitivity analysis comparing normal renal tissues and malignant renal tumor tissues; B: Sensitivity analysis comparing benign and malignant renal tumor tissues; C: Sensitivity analysis comparing normal renal tissues and benign renal tumor tissues; D: Publication bias comparing normal renal tissues and malignant renal tumor tissues; E: Publication bias comparing benign and malignant renal tumor tissues; F: Publication bias comparing normal renal tissues and benign renal tumor tissues).
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Fig4: Sensitivity analyses and funnel plots of apparent diffusion coefficient values of diffusion-weighted magnetic resonance imaging in differentiation of renal tumors (A: Sensitivity analysis comparing normal renal tissues and malignant renal tumor tissues; B: Sensitivity analysis comparing benign and malignant renal tumor tissues; C: Sensitivity analysis comparing normal renal tissues and benign renal tumor tissues; D: Publication bias comparing normal renal tissues and malignant renal tumor tissues; E: Publication bias comparing benign and malignant renal tumor tissues; F: Publication bias comparing normal renal tissues and benign renal tumor tissues).

Mentions: All studies related to comparisons between normal renal tissue and malignant renal tumor tissue, and the comparisons between malignant renal tumor tissue and benign renal tumor tissue showed no evident effect on the pooled SMD. The Contour-enhanced funnel plots, of studies investigating the comparisons between normal renal tissue and malignant renal tumor tissue as well as the comparisons between benign renal tumor tissue and malignant renal tumor tissue, indicated there was publication bias (P > 0.05) which was further confirmed by the Egger test (P > 0.05). There was no publication bias across studies that explored comparisons between normal tumor tissue and benign renal tumor tissue (P < 0.01), which was also confirmed by the Egger test (P = 0.002) (as shown in Figure 4).Figure 4


Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors.

Liu JH, Tian SF, Ju Y, Li Y, Chen AL, Chen LH, Liu AL - BMC Cancer (2015)

Sensitivity analyses and funnel plots of apparent diffusion coefficient values of diffusion-weighted magnetic resonance imaging in differentiation of renal tumors (A: Sensitivity analysis comparing normal renal tissues and malignant renal tumor tissues; B: Sensitivity analysis comparing benign and malignant renal tumor tissues; C: Sensitivity analysis comparing normal renal tissues and benign renal tumor tissues; D: Publication bias comparing normal renal tissues and malignant renal tumor tissues; E: Publication bias comparing benign and malignant renal tumor tissues; F: Publication bias comparing normal renal tissues and benign renal tumor tissues).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403953&req=5

Fig4: Sensitivity analyses and funnel plots of apparent diffusion coefficient values of diffusion-weighted magnetic resonance imaging in differentiation of renal tumors (A: Sensitivity analysis comparing normal renal tissues and malignant renal tumor tissues; B: Sensitivity analysis comparing benign and malignant renal tumor tissues; C: Sensitivity analysis comparing normal renal tissues and benign renal tumor tissues; D: Publication bias comparing normal renal tissues and malignant renal tumor tissues; E: Publication bias comparing benign and malignant renal tumor tissues; F: Publication bias comparing normal renal tissues and benign renal tumor tissues).
Mentions: All studies related to comparisons between normal renal tissue and malignant renal tumor tissue, and the comparisons between malignant renal tumor tissue and benign renal tumor tissue showed no evident effect on the pooled SMD. The Contour-enhanced funnel plots, of studies investigating the comparisons between normal renal tissue and malignant renal tumor tissue as well as the comparisons between benign renal tumor tissue and malignant renal tumor tissue, indicated there was publication bias (P > 0.05) which was further confirmed by the Egger test (P > 0.05). There was no publication bias across studies that explored comparisons between normal tumor tissue and benign renal tumor tissue (P < 0.01), which was also confirmed by the Egger test (P = 0.002) (as shown in Figure 4).Figure 4

Bottom Line: Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues.ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 222, Xigang District, Dalian, 116011, P. R China. liujinghong704@126.com.

ABSTRACT

Background: To determine the clinical value of apparent diffusion coefficient (ADC) measurement by diffusion weighted magnetic resonance imaging (DW-MRI) in differentiating renal tumors.

Methods: Electronic databases were searched using combinations of keywords and free words relating to renal tumor, ADC and DW-MRI. Based on carefully selected inclusion and exclusion criteria, relevant case-control studies were identified and the related clinical data was acquired. Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).

Results: Sixteen case-control studies were ultimately included in the present meta-analysis. These 16 high quality studies contained a combined total of 438 normal renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues. ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

Conclusions: ADC measurement by DW-MRI provided clinically useful information on the internal structure of renal tumors and could be an important radiographic index for differentiation of malignant renal tumors from benign renal tumors.

No MeSH data available.


Related in: MedlinePlus