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Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors.

Liu JH, Tian SF, Ju Y, Li Y, Chen AL, Chen LH, Liu AL - BMC Cancer (2015)

Bottom Line: Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues.ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 222, Xigang District, Dalian, 116011, P. R China. liujinghong704@126.com.

ABSTRACT

Background: To determine the clinical value of apparent diffusion coefficient (ADC) measurement by diffusion weighted magnetic resonance imaging (DW-MRI) in differentiating renal tumors.

Methods: Electronic databases were searched using combinations of keywords and free words relating to renal tumor, ADC and DW-MRI. Based on carefully selected inclusion and exclusion criteria, relevant case-control studies were identified and the related clinical data was acquired. Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).

Results: Sixteen case-control studies were ultimately included in the present meta-analysis. These 16 high quality studies contained a combined total of 438 normal renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues. ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

Conclusions: ADC measurement by DW-MRI provided clinically useful information on the internal structure of renal tumors and could be an important radiographic index for differentiation of malignant renal tumors from benign renal tumors.

No MeSH data available.


Related in: MedlinePlus

Flow chart of literature selection process.
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Fig1: Flow chart of literature selection process.

Mentions: A total of 316 studies were retrieved after the search of electronic databases. Next, the articles were reviewed, resulting in 288 eligible articles after removing duplicates. After reading the full texts, we excluded 272 articles for the following reasons: the studies were not human studies (n = 22), were letters, reviews or meta-analyses (n = 4), were not related to research topics (n = 177), were not case–control studies (n = 21), were not relevant to kidney neoplasms (n = 26), were not relevant to MRI or ADC value (n = 21), and contained incomplete data in articles (n = 1). Sixteen articles [10,14,21,29-41] (14 in English and 2 in Chinese) satisfied the inclusion and exclusion criteria and were selected for data extraction and data analysis. Figure 1 shows the literature selection processes. All included studies were published between 2004 and 2014. Among the 16 studies, study subjects in 9 trials were Asians, 6 trials were performed in Caucasians and 1 trial was conducted in African population. Based on the country of publication, 4 studies were from China, 3 from Turkey, 1 from US, 2 from Japan, 2 from Italy, and 1 each from Austria, France, Germany, Egypt. This meta-analysis included 438 normal healthy renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The three types of MRI machines used were Siemens, GE and Philips, and the b-values were 500 s/mm2, 600 s/mm2, 800 s/mm2, 1000 s/mm2, 500/1000 s/mm2 and 400/800 s/mm2. The quality score and the baseline characteristics of included studies are shown in Figure 2 and Table 1, respectively.Figure 1


Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors.

Liu JH, Tian SF, Ju Y, Li Y, Chen AL, Chen LH, Liu AL - BMC Cancer (2015)

Flow chart of literature selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403953&req=5

Fig1: Flow chart of literature selection process.
Mentions: A total of 316 studies were retrieved after the search of electronic databases. Next, the articles were reviewed, resulting in 288 eligible articles after removing duplicates. After reading the full texts, we excluded 272 articles for the following reasons: the studies were not human studies (n = 22), were letters, reviews or meta-analyses (n = 4), were not related to research topics (n = 177), were not case–control studies (n = 21), were not relevant to kidney neoplasms (n = 26), were not relevant to MRI or ADC value (n = 21), and contained incomplete data in articles (n = 1). Sixteen articles [10,14,21,29-41] (14 in English and 2 in Chinese) satisfied the inclusion and exclusion criteria and were selected for data extraction and data analysis. Figure 1 shows the literature selection processes. All included studies were published between 2004 and 2014. Among the 16 studies, study subjects in 9 trials were Asians, 6 trials were performed in Caucasians and 1 trial was conducted in African population. Based on the country of publication, 4 studies were from China, 3 from Turkey, 1 from US, 2 from Japan, 2 from Italy, and 1 each from Austria, France, Germany, Egypt. This meta-analysis included 438 normal healthy renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The three types of MRI machines used were Siemens, GE and Philips, and the b-values were 500 s/mm2, 600 s/mm2, 800 s/mm2, 1000 s/mm2, 500/1000 s/mm2 and 400/800 s/mm2. The quality score and the baseline characteristics of included studies are shown in Figure 2 and Table 1, respectively.Figure 1

Bottom Line: Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues.ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 222, Xigang District, Dalian, 116011, P. R China. liujinghong704@126.com.

ABSTRACT

Background: To determine the clinical value of apparent diffusion coefficient (ADC) measurement by diffusion weighted magnetic resonance imaging (DW-MRI) in differentiating renal tumors.

Methods: Electronic databases were searched using combinations of keywords and free words relating to renal tumor, ADC and DW-MRI. Based on carefully selected inclusion and exclusion criteria, relevant case-control studies were identified and the related clinical data was acquired. Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX).

Results: Sixteen case-control studies were ultimately included in the present meta-analysis. These 16 high quality studies contained a combined total of 438 normal renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues. ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue.

Conclusions: ADC measurement by DW-MRI provided clinically useful information on the internal structure of renal tumors and could be an important radiographic index for differentiation of malignant renal tumors from benign renal tumors.

No MeSH data available.


Related in: MedlinePlus