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Comparability of tumor-cytogenetics and -DNA-cytometry.

Böcking A - Mol Cytogenet (2015)

Bottom Line: Knowledge of the karyotypes of cancer cells is the theoretical underpinning of diagnostic/prognostic DNA-cytometry.Currently the translation is hampered by different terminologies of both fields.The following letter tries to close current gaps between the two fields by harmonizing their different terminologies.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathology, City Hospital Düren, Roonstrasse 30, 52351 Düren, Germany.

ABSTRACT
Knowledge of the karyotypes of cancer cells is the theoretical underpinning of diagnostic/prognostic DNA-cytometry. Currently the translation is hampered by different terminologies of both fields. The following letter tries to close current gaps between the two fields by harmonizing their different terminologies.

No MeSH data available.


Related in: MedlinePlus

Rare nuclei with abnormally high DNA-contents in c, correspondig to non-clonal aneuploidy. 1c = DNA-content of one haploid chromosomal set. From a bile-duct brushing with in-situ cancer. Specifically stained for DNA according to Feulgen.
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Fig1: Rare nuclei with abnormally high DNA-contents in c, correspondig to non-clonal aneuploidy. 1c = DNA-content of one haploid chromosomal set. From a bile-duct brushing with in-situ cancer. Specifically stained for DNA according to Feulgen.

Mentions: What Bloomfield et al. call “non clonal aneuploidy” results in “single-cell aneuploidy” in DNA-image-cytometry. We call these abnormal DNA-values of single cells “rare events” (Figure 1). The detection of non clonal aneuploidy in atypical hyperplasias or dysplasias is associated with a lower PPV in subsequent months as compared with DNA-stemline-aneuploidy (e.g. 41,2% as compared to 76,3% for Pap-smears: Grote et al., [3]). As this PPV is too high to be left for surveillance only, we also recommend therapy of the respective lesions or at least tight follow-up with repeated biopsies.Figure 1


Comparability of tumor-cytogenetics and -DNA-cytometry.

Böcking A - Mol Cytogenet (2015)

Rare nuclei with abnormally high DNA-contents in c, correspondig to non-clonal aneuploidy. 1c = DNA-content of one haploid chromosomal set. From a bile-duct brushing with in-situ cancer. Specifically stained for DNA according to Feulgen.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403948&req=5

Fig1: Rare nuclei with abnormally high DNA-contents in c, correspondig to non-clonal aneuploidy. 1c = DNA-content of one haploid chromosomal set. From a bile-duct brushing with in-situ cancer. Specifically stained for DNA according to Feulgen.
Mentions: What Bloomfield et al. call “non clonal aneuploidy” results in “single-cell aneuploidy” in DNA-image-cytometry. We call these abnormal DNA-values of single cells “rare events” (Figure 1). The detection of non clonal aneuploidy in atypical hyperplasias or dysplasias is associated with a lower PPV in subsequent months as compared with DNA-stemline-aneuploidy (e.g. 41,2% as compared to 76,3% for Pap-smears: Grote et al., [3]). As this PPV is too high to be left for surveillance only, we also recommend therapy of the respective lesions or at least tight follow-up with repeated biopsies.Figure 1

Bottom Line: Knowledge of the karyotypes of cancer cells is the theoretical underpinning of diagnostic/prognostic DNA-cytometry.Currently the translation is hampered by different terminologies of both fields.The following letter tries to close current gaps between the two fields by harmonizing their different terminologies.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathology, City Hospital Düren, Roonstrasse 30, 52351 Düren, Germany.

ABSTRACT
Knowledge of the karyotypes of cancer cells is the theoretical underpinning of diagnostic/prognostic DNA-cytometry. Currently the translation is hampered by different terminologies of both fields. The following letter tries to close current gaps between the two fields by harmonizing their different terminologies.

No MeSH data available.


Related in: MedlinePlus