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Potent natural products and herbal medicines for treating liver fibrosis.

Chen SR, Chen XP, Lu JJ, Wang Y, Wang YT - Chin Med (2015)

Bottom Line: The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue.The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways.This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao, SAR China.

ABSTRACT
Liver fibrosis is a wound-healing response to chronic liver injury characterized by progressive inflammation and deposition of extracellular matrix components. The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue. The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways. This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.

No MeSH data available.


Related in: MedlinePlus

Signaling pathway mediates hepatic fibrogenesis: (A) the TGF-β1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFβ1/NFκB pathway.
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Fig1: Signaling pathway mediates hepatic fibrogenesis: (A) the TGF-β1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFβ1/NFκB pathway.

Mentions: TGF-β1 is a member of the TGF β superfamily [11] and is involved in liver fibrosis (Figure 1A). Under normal conditions, TGF-β1 binds to latency-associated peptide and remains inactivated. Upon activation, TGF-β1 binds to its receptors and phosphorylates the downstream signal SMAD2/3. Phosphorylated SMAD2/3 recruits the common mediator SMAD4 to form a hetero-oligomer complex. The SMAD complex then translocates into the nucleus and activates transcription of collagens [12]. Elevated collagen expression induces trans-differentiation of myofibroblasts, which secrete ECMS that can overwhelm the cellular capacity for ECM degradation and lead to fibrosis [13].Figure 1


Potent natural products and herbal medicines for treating liver fibrosis.

Chen SR, Chen XP, Lu JJ, Wang Y, Wang YT - Chin Med (2015)

Signaling pathway mediates hepatic fibrogenesis: (A) the TGF-β1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFβ1/NFκB pathway.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403904&req=5

Fig1: Signaling pathway mediates hepatic fibrogenesis: (A) the TGF-β1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFβ1/NFκB pathway.
Mentions: TGF-β1 is a member of the TGF β superfamily [11] and is involved in liver fibrosis (Figure 1A). Under normal conditions, TGF-β1 binds to latency-associated peptide and remains inactivated. Upon activation, TGF-β1 binds to its receptors and phosphorylates the downstream signal SMAD2/3. Phosphorylated SMAD2/3 recruits the common mediator SMAD4 to form a hetero-oligomer complex. The SMAD complex then translocates into the nucleus and activates transcription of collagens [12]. Elevated collagen expression induces trans-differentiation of myofibroblasts, which secrete ECMS that can overwhelm the cellular capacity for ECM degradation and lead to fibrosis [13].Figure 1

Bottom Line: The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue.The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways.This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao, SAR China.

ABSTRACT
Liver fibrosis is a wound-healing response to chronic liver injury characterized by progressive inflammation and deposition of extracellular matrix components. The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue. The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways. This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.

No MeSH data available.


Related in: MedlinePlus