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Assessment of vascular function in individuals with hyperglycemia: a cross-sectional study of glucose - induced changes in digital volume pulse.

Alaei-Shahmiri F, Zhao Y, Sherriff J - J Diabetes Metab Disord (2015)

Bottom Line: Our results showed a significantly higher (Ln) fasting SI in the hyperglycemic group compared with the control group (2.19 ± 0.32 vs. 1.96 ± 0.22, P = 0.005).However, this pattern reversed after adjustment for potential confounders.Increased arterial stiffness in pre-diabetic subjects is strongly associated with age and MAP.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Curtin University, Kent Street, Bentley, Perth, Western Australia ; Iran University of Medical Sciences (IUMS), Tehran, Iran.

ABSTRACT

Background: Arterial stiffness is an independent risk factor for cardiovascular disease and its progression may be accelerated in the presence of hyperglycemia, either fasting or postprandial. The current study assessed vascular function in subjects with pre-diabetes hyperglycemia, using digital volume pulse analysis technique.

Methods: We conducted a cross-sectional study examining vascular function in the fasting and postprandial (glucose-induced) state in 44 adults, consisting of 17 subjects with pre-diabetic hyperglycemia and 27 normoglycemic volunteers. Photoplethysmography of the digital volume pulse (DVP) was used to determine stiffness index (SI) and reflective index (RI), as main measures of larger artery stiffness and vascular tone, respectively.

Results: Our results showed a significantly higher (Ln) fasting SI in the hyperglycemic group compared with the control group (2.19 ± 0.32 vs. 1.96 ± 0.22, P = 0.005). However, this pattern reversed after adjustment for potential confounders. In multiple linear regression analysis, (Ln) SI was related to age (β = 0.01, 95% CI: 0.01-0.02, P < 0.001) and systolic blood pressure (SBP) (β = 0.01, 95% CI: 0.00-0.01, P < 0.05), but not with W/H, diastolic blood pressure (DBP), fasting plasma glucose (FPG) or serum lipids. Furthermore, age (β = 0.02, 95% CI: 0.01-0.03, P < 0.001) and mean arterial pressure (MAP) (β = 0.01, 95% CI: 0.00-0.02, P < 0.05) were found as the strong predictors of fasting SI in hyperglycemic group. Neither FPG nor 2-h plasma glucose was a significant predictor for SI in hyperglycemic group, after accounting for age and MAP. Subjects with hyperglycemia had a 15% blunted change in postprandial AUCs for RI, adjusted for the respective baseline measurements (-9.40 ± 3.59 vs. -11.00 ± 2.84%) but these did not attain statistical significance.

Conclusion: Increased arterial stiffness in pre-diabetic subjects is strongly associated with age and MAP. The increased DVP-derived SI reported in patients with pre-diabetic hyperglycemia may result from different frequently accompanied risk factors not just glycemic changes in this range.

No MeSH data available.


Related in: MedlinePlus

Indices derived from digital volume pulse analysis. SI, stiffness index; RI, reflection index; PPT, peak-to-peak time.
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Fig1: Indices derived from digital volume pulse analysis. SI, stiffness index; RI, reflection index; PPT, peak-to-peak time.

Mentions: The technique of DVP is based on measuring infra-red light transmission through the finger (photoplethysmography) [8]. Photoplethysmography of DVP is used to determine stiffness index (SI) and reflective index (RI), as main measures of larger artery stiffness and vascular tone of small arteries, respectively. RI is computed by the% ratio of the heights (amplitude) of reflected wave (diastolic component) to the systolic peak, and is a measure of pulse wave reflection and the small artery tone. SI can be calculated from the subject’s height divided by the time between systolic and diastolic peaks, and is a marker of large arterial stiffness [Figure 1] [11].Figure 1


Assessment of vascular function in individuals with hyperglycemia: a cross-sectional study of glucose - induced changes in digital volume pulse.

Alaei-Shahmiri F, Zhao Y, Sherriff J - J Diabetes Metab Disord (2015)

Indices derived from digital volume pulse analysis. SI, stiffness index; RI, reflection index; PPT, peak-to-peak time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403892&req=5

Fig1: Indices derived from digital volume pulse analysis. SI, stiffness index; RI, reflection index; PPT, peak-to-peak time.
Mentions: The technique of DVP is based on measuring infra-red light transmission through the finger (photoplethysmography) [8]. Photoplethysmography of DVP is used to determine stiffness index (SI) and reflective index (RI), as main measures of larger artery stiffness and vascular tone of small arteries, respectively. RI is computed by the% ratio of the heights (amplitude) of reflected wave (diastolic component) to the systolic peak, and is a measure of pulse wave reflection and the small artery tone. SI can be calculated from the subject’s height divided by the time between systolic and diastolic peaks, and is a marker of large arterial stiffness [Figure 1] [11].Figure 1

Bottom Line: Our results showed a significantly higher (Ln) fasting SI in the hyperglycemic group compared with the control group (2.19 ± 0.32 vs. 1.96 ± 0.22, P = 0.005).However, this pattern reversed after adjustment for potential confounders.Increased arterial stiffness in pre-diabetic subjects is strongly associated with age and MAP.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Curtin University, Kent Street, Bentley, Perth, Western Australia ; Iran University of Medical Sciences (IUMS), Tehran, Iran.

ABSTRACT

Background: Arterial stiffness is an independent risk factor for cardiovascular disease and its progression may be accelerated in the presence of hyperglycemia, either fasting or postprandial. The current study assessed vascular function in subjects with pre-diabetes hyperglycemia, using digital volume pulse analysis technique.

Methods: We conducted a cross-sectional study examining vascular function in the fasting and postprandial (glucose-induced) state in 44 adults, consisting of 17 subjects with pre-diabetic hyperglycemia and 27 normoglycemic volunteers. Photoplethysmography of the digital volume pulse (DVP) was used to determine stiffness index (SI) and reflective index (RI), as main measures of larger artery stiffness and vascular tone, respectively.

Results: Our results showed a significantly higher (Ln) fasting SI in the hyperglycemic group compared with the control group (2.19 ± 0.32 vs. 1.96 ± 0.22, P = 0.005). However, this pattern reversed after adjustment for potential confounders. In multiple linear regression analysis, (Ln) SI was related to age (β = 0.01, 95% CI: 0.01-0.02, P < 0.001) and systolic blood pressure (SBP) (β = 0.01, 95% CI: 0.00-0.01, P < 0.05), but not with W/H, diastolic blood pressure (DBP), fasting plasma glucose (FPG) or serum lipids. Furthermore, age (β = 0.02, 95% CI: 0.01-0.03, P < 0.001) and mean arterial pressure (MAP) (β = 0.01, 95% CI: 0.00-0.02, P < 0.05) were found as the strong predictors of fasting SI in hyperglycemic group. Neither FPG nor 2-h plasma glucose was a significant predictor for SI in hyperglycemic group, after accounting for age and MAP. Subjects with hyperglycemia had a 15% blunted change in postprandial AUCs for RI, adjusted for the respective baseline measurements (-9.40 ± 3.59 vs. -11.00 ± 2.84%) but these did not attain statistical significance.

Conclusion: Increased arterial stiffness in pre-diabetic subjects is strongly associated with age and MAP. The increased DVP-derived SI reported in patients with pre-diabetic hyperglycemia may result from different frequently accompanied risk factors not just glycemic changes in this range.

No MeSH data available.


Related in: MedlinePlus