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Dynamic responses of selective brain white matter fiber tracts to binge alcohol and recovery in the rat.

Pfefferbaum A, Zahr NM, Mayer D, Rohlfing T, Sullivan EV - PLoS ONE (2015)

Bottom Line: Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix.These effects were confirmed with tract-based spatial statistics (TBSS).The directionality of changes in DTI metrics reproduce those observed in human alcoholism.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Program, SRI International, Menlo Park, CA, United States of America; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America.

ABSTRACT
To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure. Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days of intragastric alcohol to blood alcohol levels of ~250 mg/dL; and after one week of recovery. Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix. These effects were confirmed with tract-based spatial statistics (TBSS). The directionality of changes in DTI metrics reproduce those observed in human alcoholism. That a single exposure to binge alcohol can cause substantial transient changes detectable in DTI metrics demonstrates the potential for rapid neuroplasticity.

No MeSH data available.


Related in: MedlinePlus

Graphs show quantified results of λL (top) and λT (bottom) in corpus callosum genu and splenium.
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pone.0124885.g005: Graphs show quantified results of λL (top) and λT (bottom) in corpus callosum genu and splenium.

Mentions: Two-group-by-three session interactions were also significant for λL (F(2,55) = 4.44, p = .02) but not λT (F(2,55) = 1.88, p = .16) in genu (Fig 5). Here the pattern of changes were similar to FA, that is, attributable to a drop in λL from DTI 1 to DTI 2, followed by a return of λL to baseline levels at DTI 3, in the alcohol but not control group. Significant group-by-session interactions were noted for both λL (left: F(2,55) = 3.42, p = .04; right: (F(2,55) = 5.45, p = .007) and λT (left: F(2,55) = 10.94, p = .0001; right: (F(2,55) = 12.5, p = .00003) in fimbria-fornix, but followed the MD pattern, that is, both were elevated at DTI 2 but returned to baseline at DTI 3 in the alcohol-treated group only (Fig 6). The same patterns were present in the groups including animals that only completed the first two scanning sessions.


Dynamic responses of selective brain white matter fiber tracts to binge alcohol and recovery in the rat.

Pfefferbaum A, Zahr NM, Mayer D, Rohlfing T, Sullivan EV - PLoS ONE (2015)

Graphs show quantified results of λL (top) and λT (bottom) in corpus callosum genu and splenium.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403879&req=5

pone.0124885.g005: Graphs show quantified results of λL (top) and λT (bottom) in corpus callosum genu and splenium.
Mentions: Two-group-by-three session interactions were also significant for λL (F(2,55) = 4.44, p = .02) but not λT (F(2,55) = 1.88, p = .16) in genu (Fig 5). Here the pattern of changes were similar to FA, that is, attributable to a drop in λL from DTI 1 to DTI 2, followed by a return of λL to baseline levels at DTI 3, in the alcohol but not control group. Significant group-by-session interactions were noted for both λL (left: F(2,55) = 3.42, p = .04; right: (F(2,55) = 5.45, p = .007) and λT (left: F(2,55) = 10.94, p = .0001; right: (F(2,55) = 12.5, p = .00003) in fimbria-fornix, but followed the MD pattern, that is, both were elevated at DTI 2 but returned to baseline at DTI 3 in the alcohol-treated group only (Fig 6). The same patterns were present in the groups including animals that only completed the first two scanning sessions.

Bottom Line: Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix.These effects were confirmed with tract-based spatial statistics (TBSS).The directionality of changes in DTI metrics reproduce those observed in human alcoholism.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Program, SRI International, Menlo Park, CA, United States of America; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America.

ABSTRACT
To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure. Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days of intragastric alcohol to blood alcohol levels of ~250 mg/dL; and after one week of recovery. Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix. These effects were confirmed with tract-based spatial statistics (TBSS). The directionality of changes in DTI metrics reproduce those observed in human alcoholism. That a single exposure to binge alcohol can cause substantial transient changes detectable in DTI metrics demonstrates the potential for rapid neuroplasticity.

No MeSH data available.


Related in: MedlinePlus