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Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial.

Trabal J, Forga M, Leyes P, Torres F, Rubio J, Prieto E, Farran-Codina A - Clin Interv Aging (2015)

Bottom Line: Clinically significant gains were found in isometric leg strength at both assessment time points.No significant changes were observed for the rest of the outcomes.The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.

ABSTRACT

Objective: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.

Methods: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.

Results: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.

Conclusion: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.

No MeSH data available.


Related in: MedlinePlus

Flowchart of study groups at different time points.Note: Subject dropout is reported as “lost”.
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f1-cia-10-713: Flowchart of study groups at different time points.Note: Subject dropout is reported as “lost”.

Mentions: From December 2009 to December 2012, a total of 82 older adults over 70 years of age were screened for inclusion criteria in different nursing homes and adult day care centers within the Barcelona metropolitan area; of these, 30 subjects were recruited to participate in the study. The exclusion criteria were: chronic kidney disease, a disability that did not allow the practice of exercise (eg, a fractured limb during the last 6 months), performing resistance training on a regular basis, dietary protein restriction, following a low-calorie diet for weight loss, the need for oral nutritional supplementation or enteral nutrition, the need for drugs with orexigenic or anabolic effects, and long-term use of corticosteroids. Figure 1 illustrates the subject screening process, randomization to treatments, and time points of assessment over the course of the 12-week intervention. All subjects were given oral and written information about the nature of the study before a signed informed consent was obtained. The procedures used were in accordance with ethical standards and with the 2008 Helsinki Declaration. Study approval was granted by the Ethics Committee of Clinical Research of the Hospital Clínic Universitari de Barcelona.


Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial.

Trabal J, Forga M, Leyes P, Torres F, Rubio J, Prieto E, Farran-Codina A - Clin Interv Aging (2015)

Flowchart of study groups at different time points.Note: Subject dropout is reported as “lost”.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403814&req=5

f1-cia-10-713: Flowchart of study groups at different time points.Note: Subject dropout is reported as “lost”.
Mentions: From December 2009 to December 2012, a total of 82 older adults over 70 years of age were screened for inclusion criteria in different nursing homes and adult day care centers within the Barcelona metropolitan area; of these, 30 subjects were recruited to participate in the study. The exclusion criteria were: chronic kidney disease, a disability that did not allow the practice of exercise (eg, a fractured limb during the last 6 months), performing resistance training on a regular basis, dietary protein restriction, following a low-calorie diet for weight loss, the need for oral nutritional supplementation or enteral nutrition, the need for drugs with orexigenic or anabolic effects, and long-term use of corticosteroids. Figure 1 illustrates the subject screening process, randomization to treatments, and time points of assessment over the course of the 12-week intervention. All subjects were given oral and written information about the nature of the study before a signed informed consent was obtained. The procedures used were in accordance with ethical standards and with the 2008 Helsinki Declaration. Study approval was granted by the Ethics Committee of Clinical Research of the Hospital Clínic Universitari de Barcelona.

Bottom Line: Clinically significant gains were found in isometric leg strength at both assessment time points.No significant changes were observed for the rest of the outcomes.The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.

ABSTRACT

Objective: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.

Methods: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.

Results: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.

Conclusion: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.

No MeSH data available.


Related in: MedlinePlus