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Aspiration pneumonia and bronchopneumonia in progressive supranuclear palsy treated with qing fei tang: two case reports.

Nozaki I, Kato-Motozaki Y, Ikeda T, Takahashi K, Tagami A, Ishida C, Komai K - J Med Case Rep (2015)

Bottom Line: Qing fei tang, which is used for various respiratory diseases, is useful for reducing relapse of aspiration pneumonia and bronchopneumonia in stroke, but the effect remains unknown in Parkinson's syndrome.Both of our patients clearly showed a reduced incidence of respiratory infection.Both of our patients clearly showed a reduced incidence of respiratory infection after the administration of qing fei tang.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1, Takara-machi, Kanazawa, 920-8640, Japan. ichi51@med.kanazawa-u.ac.jp.

ABSTRACT

Introduction: Qing fei tang, which is used for various respiratory diseases, is useful for reducing relapse of aspiration pneumonia and bronchopneumonia in stroke, but the effect remains unknown in Parkinson's syndrome. We report two cases of Japanese patients with progressive supranuclear palsy and relapsing aspiration pneumonia and bronchopneumonia, which was successfully prevented by qing fei tang.

Case presentation: Two Japanese men with progressive supranuclear palsy and receiving total enteral feeding (patient one (66-years-old) and patient two (76-years-old)) had experienced recurrent aspiration pneumonia and bronchopneumonia, which was unresponsive to conventional therapy. The respiratory infection developed twice at intervals of two months in patient one, and nine times at almost monthly intervals in patient two. Thereafter, they were given qing fei tang. After administration of qing fei tang, the respiratory infection reoccurred only once; after 5.5 months for patient one, and six months for patient two. Both of our patients clearly showed a reduced incidence of respiratory infection.

Conclusions: Both of our patients clearly showed a reduced incidence of respiratory infection after the administration of qing fei tang. Qing fei tang could be useful for the prevention of recurrent aspiration pneumonia and bronchopneumonia in progressive supranuclear palsy.

No MeSH data available.


Related in: MedlinePlus

The clinical course of patient two. The incidence of aspiration pneumonia and bronchopneumonia, which are shown by black triangles was shown before and after the administration of qing fei tang at X month in patient two.
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Fig2: The clinical course of patient two. The incidence of aspiration pneumonia and bronchopneumonia, which are shown by black triangles was shown before and after the administration of qing fei tang at X month in patient two.

Mentions: A 74-year-old Japanese man presented to us with a three-year history of difficulty in moving his upper limbs, a tendency to fall, and slow movements. His neurological examination revealed supranuclear vertical gaze palsy, dysarthria, bradykinesia, muscular rigidity, and loss of postural reflex. Magnetic resonance imaging of his head demonstrated severe atrophy of his midbrain tegmentum. These clinical manifestations led to a diagnosis of probable PSP according to NINDS-SPSP criteria [2]. A PEG was performed in a bedridden condition because of progressive dysphagia 23 months after the diagnosis, but then aspiration pneumonia and bronchopneumonia developed nine times during 10 months, at intervals of about one month, with medication including ambroxol, L-carbocysteine, clarithromycin, bromhexine, and amantadine (Figure 2). Qing fei tang was given daily at a dose of 9g, and then aspiration pneumonia occurred only once, six months after starting the treatment (Figure 2). The types of bacteria in his sputum did not change compared with before starting qing fei tang (P. aeruginosa, MRSA and Klebsiella pneumoniae).Figure 2


Aspiration pneumonia and bronchopneumonia in progressive supranuclear palsy treated with qing fei tang: two case reports.

Nozaki I, Kato-Motozaki Y, Ikeda T, Takahashi K, Tagami A, Ishida C, Komai K - J Med Case Rep (2015)

The clinical course of patient two. The incidence of aspiration pneumonia and bronchopneumonia, which are shown by black triangles was shown before and after the administration of qing fei tang at X month in patient two.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403770&req=5

Fig2: The clinical course of patient two. The incidence of aspiration pneumonia and bronchopneumonia, which are shown by black triangles was shown before and after the administration of qing fei tang at X month in patient two.
Mentions: A 74-year-old Japanese man presented to us with a three-year history of difficulty in moving his upper limbs, a tendency to fall, and slow movements. His neurological examination revealed supranuclear vertical gaze palsy, dysarthria, bradykinesia, muscular rigidity, and loss of postural reflex. Magnetic resonance imaging of his head demonstrated severe atrophy of his midbrain tegmentum. These clinical manifestations led to a diagnosis of probable PSP according to NINDS-SPSP criteria [2]. A PEG was performed in a bedridden condition because of progressive dysphagia 23 months after the diagnosis, but then aspiration pneumonia and bronchopneumonia developed nine times during 10 months, at intervals of about one month, with medication including ambroxol, L-carbocysteine, clarithromycin, bromhexine, and amantadine (Figure 2). Qing fei tang was given daily at a dose of 9g, and then aspiration pneumonia occurred only once, six months after starting the treatment (Figure 2). The types of bacteria in his sputum did not change compared with before starting qing fei tang (P. aeruginosa, MRSA and Klebsiella pneumoniae).Figure 2

Bottom Line: Qing fei tang, which is used for various respiratory diseases, is useful for reducing relapse of aspiration pneumonia and bronchopneumonia in stroke, but the effect remains unknown in Parkinson's syndrome.Both of our patients clearly showed a reduced incidence of respiratory infection.Both of our patients clearly showed a reduced incidence of respiratory infection after the administration of qing fei tang.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1, Takara-machi, Kanazawa, 920-8640, Japan. ichi51@med.kanazawa-u.ac.jp.

ABSTRACT

Introduction: Qing fei tang, which is used for various respiratory diseases, is useful for reducing relapse of aspiration pneumonia and bronchopneumonia in stroke, but the effect remains unknown in Parkinson's syndrome. We report two cases of Japanese patients with progressive supranuclear palsy and relapsing aspiration pneumonia and bronchopneumonia, which was successfully prevented by qing fei tang.

Case presentation: Two Japanese men with progressive supranuclear palsy and receiving total enteral feeding (patient one (66-years-old) and patient two (76-years-old)) had experienced recurrent aspiration pneumonia and bronchopneumonia, which was unresponsive to conventional therapy. The respiratory infection developed twice at intervals of two months in patient one, and nine times at almost monthly intervals in patient two. Thereafter, they were given qing fei tang. After administration of qing fei tang, the respiratory infection reoccurred only once; after 5.5 months for patient one, and six months for patient two. Both of our patients clearly showed a reduced incidence of respiratory infection.

Conclusions: Both of our patients clearly showed a reduced incidence of respiratory infection after the administration of qing fei tang. Qing fei tang could be useful for the prevention of recurrent aspiration pneumonia and bronchopneumonia in progressive supranuclear palsy.

No MeSH data available.


Related in: MedlinePlus