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Epidemiology of childhood enterovirus infections in Hangzhou, China.

Li W, Zhang X, Chen X, Cheng YP, Wu YD, Shu Q, Chen XJ, Shang SQ - Virol. J. (2015)

Bottom Line: Samples were collected from children admitted to the inpatient wards and outpatient departments between January 2010 and December 2012 in the Children's Hospital, Zhejiang University School of Medicine.The annual enterovirus-positive rate decreased from 32.78% in 2010 to 14.23% in 2012.Serotypes causing severe symptoms such as HFMD including EV71 and CA16 were decreasing, while the proportion of unidentified EV serotypes causing herpangina and viral encephalitis were on the rise.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng road, Hangzhou, 310003, China. liwei19860607@163.com.

ABSTRACT

Background: There are over 100 serotypes of enterovirus species A-D, which are the common cause of various symptoms in infants, such as meningitis, encephalitis and hand foot mouth disease (HFMD). This study aims to investigate the epidemiological characteristics of enteroviruses in Hangzhou, Zhejiang province, China, and to provide relevant information to guide public health responses and interventions.

Methods: Systematic surveillance was conducted on enterovirus infections. Samples were collected from children admitted to the inpatient wards and outpatient departments between January 2010 and December 2012 in the Children's Hospital, Zhejiang University School of Medicine. Enteroviruses from all specimens were detected by RT-PCR using a commercialized detection kit.

Results: From 13026 samples collected and examined, 2673 (21.21%) were found positive for enteroviruses. The annual enterovirus-positive rate decreased from 32.78% in 2010 to 14.23% in 2012. Positivity rate for enteroviruses was highest among children aged less than 5 years. The monthly positivity rate for enterovirus infection ranged from 2.6% to 34.83%, with a peak in June and July. Serotypes causing severe symptoms such as HFMD including EV71 and CA16 were decreasing, while the proportion of unidentified EV serotypes causing herpangina and viral encephalitis were on the rise.

Conclusions: EV infection is highly prevalent among young children in Hangzhou, as it is in the most other parts of the world. Further surveillance using methods that can subtype all EVs is warranted to better monitor these infections and their etiology.

No MeSH data available.


Related in: MedlinePlus

Monthly distribution of entervirus infection among children younger than 14 years.
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Fig2: Monthly distribution of entervirus infection among children younger than 14 years.

Mentions: EV infections occurred year-round, but there was a well-defined seasonality during the 3-year surveillance period. The monthly positive detection rates for EV infections all year round ranged from 2.57% to 34.62%, with a peak in June and July, and steadily declined in the previous and the following months (Figure 2).Figure 2


Epidemiology of childhood enterovirus infections in Hangzhou, China.

Li W, Zhang X, Chen X, Cheng YP, Wu YD, Shu Q, Chen XJ, Shang SQ - Virol. J. (2015)

Monthly distribution of entervirus infection among children younger than 14 years.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403759&req=5

Fig2: Monthly distribution of entervirus infection among children younger than 14 years.
Mentions: EV infections occurred year-round, but there was a well-defined seasonality during the 3-year surveillance period. The monthly positive detection rates for EV infections all year round ranged from 2.57% to 34.62%, with a peak in June and July, and steadily declined in the previous and the following months (Figure 2).Figure 2

Bottom Line: Samples were collected from children admitted to the inpatient wards and outpatient departments between January 2010 and December 2012 in the Children's Hospital, Zhejiang University School of Medicine.The annual enterovirus-positive rate decreased from 32.78% in 2010 to 14.23% in 2012.Serotypes causing severe symptoms such as HFMD including EV71 and CA16 were decreasing, while the proportion of unidentified EV serotypes causing herpangina and viral encephalitis were on the rise.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng road, Hangzhou, 310003, China. liwei19860607@163.com.

ABSTRACT

Background: There are over 100 serotypes of enterovirus species A-D, which are the common cause of various symptoms in infants, such as meningitis, encephalitis and hand foot mouth disease (HFMD). This study aims to investigate the epidemiological characteristics of enteroviruses in Hangzhou, Zhejiang province, China, and to provide relevant information to guide public health responses and interventions.

Methods: Systematic surveillance was conducted on enterovirus infections. Samples were collected from children admitted to the inpatient wards and outpatient departments between January 2010 and December 2012 in the Children's Hospital, Zhejiang University School of Medicine. Enteroviruses from all specimens were detected by RT-PCR using a commercialized detection kit.

Results: From 13026 samples collected and examined, 2673 (21.21%) were found positive for enteroviruses. The annual enterovirus-positive rate decreased from 32.78% in 2010 to 14.23% in 2012. Positivity rate for enteroviruses was highest among children aged less than 5 years. The monthly positivity rate for enterovirus infection ranged from 2.6% to 34.83%, with a peak in June and July. Serotypes causing severe symptoms such as HFMD including EV71 and CA16 were decreasing, while the proportion of unidentified EV serotypes causing herpangina and viral encephalitis were on the rise.

Conclusions: EV infection is highly prevalent among young children in Hangzhou, as it is in the most other parts of the world. Further surveillance using methods that can subtype all EVs is warranted to better monitor these infections and their etiology.

No MeSH data available.


Related in: MedlinePlus