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Diabetes mellitus and risk factors in human immunodeficiency virus-infected individuals at Jimma University Specialized Hospital, Southwest Ethiopia.

Mohammed AE, Shenkute TY, Gebisa WC - Diabetes Metab Syndr Obes (2015)

Bottom Line: To assess the magnitude of diabetes mellitus (DM) and associated risk factors in human immunodeficiency virus (HIV)-infected individuals.Two hundred and ninety-one (74%) and 77 (19.6%) of the study participants had normal (70-110 mg/dL) and impaired (111-125 mg/dL) fasting blood glucose values, respectively.After adjusting for the other variables, age (adjusted odds ratio [AOR] =4.812, 95% confidence interval [CI]: 1.668-13.881, P=0.004), duration of highly active antiretroviral therapy (HAART) (AOR =26.928, 95% CI: 3.722-194.822, P=0.001), hypertension (AOR =4.779, 95% CI: 1.646-13.874, P=0.004), and low-density lipoprotein cholesterol (AOR =5.669, 95% CI: 1.849-17.382, P=0.004) were significantly associated with DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Sciences and Pathology, College of Health Sciences, Jimma University, Jimma, Ethiopia.

ABSTRACT

Background: Globally, diabetes is rising dramatically causing high health burden in low- and middle-income countries. It is estimated that about 382 million people had diabetes in 2013. In 2013, diabetes caused 5.1 million deaths globally. Almost 80% of diabetes deaths occur in low- and middle-income countries.

Purpose: To assess the magnitude of diabetes mellitus (DM) and associated risk factors in human immunodeficiency virus (HIV)-infected individuals.

Methods: An institution-based cross-sectional study was conducted from April to May 2014 at Jimma University Specialized Hospital. Convenient sampling technique was implemented. Sociodemographic and anthropometric data were collected by senior clinical nurses. Venous blood was collected from each study participant. Serum glucose and lipid profile of the study participants was measured using HumaStar 80 spectrophotometer. Data were analyzed using SPSS version 20. Bivariate and multivariate logistic regressions were utilized.

Results: A total of 393 HIV-infected individuals of age ranging from 21 years to 75 years had enrolled in this study. The overall prevalence of DM in this study was 6.4% (n=25). Two hundred and ninety-one (74%) and 77 (19.6%) of the study participants had normal (70-110 mg/dL) and impaired (111-125 mg/dL) fasting blood glucose values, respectively. After adjusting for the other variables, age (adjusted odds ratio [AOR] =4.812, 95% confidence interval [CI]: 1.668-13.881, P=0.004), duration of highly active antiretroviral therapy (HAART) (AOR =26.928, 95% CI: 3.722-194.822, P=0.001), hypertension (AOR =4.779, 95% CI: 1.646-13.874, P=0.004), and low-density lipoprotein cholesterol (AOR =5.669, 95% CI: 1.849-17.382, P=0.004) were significantly associated with DM.

Conclusion: HAART may have an impact on the cause of diabetes. Hence, HIV-infected individuals should be screened for diabetes, both before and after initiation of HAART.

No MeSH data available.


Related in: MedlinePlus

Classification of serum glucose test values of HIV-infected individuals at JUSH comprehensive chronic care and training center, Southwest Ethiopia, 2014.Abbreviations: HIV, human immunodeficiency virus; JUSH, Jimma University Specialized Hospital; IFG, impaired fasting glucose; DM, diabetes mellitus.
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f1-dmso-8-197: Classification of serum glucose test values of HIV-infected individuals at JUSH comprehensive chronic care and training center, Southwest Ethiopia, 2014.Abbreviations: HIV, human immunodeficiency virus; JUSH, Jimma University Specialized Hospital; IFG, impaired fasting glucose; DM, diabetes mellitus.

Mentions: The overall prevalence of DM in this study was 6.4% (n=25). Seven of the DM-positive individuals knew about their DM status before our study, and they did not start using drug. Two hundred and ninety-one (74%) and 77 (19.6%) of the study participants had normal glucose value (70–110 mg/dL) and impaired fasting glucose value (111–125 mg/dL), respectively (Figure 1).


Diabetes mellitus and risk factors in human immunodeficiency virus-infected individuals at Jimma University Specialized Hospital, Southwest Ethiopia.

Mohammed AE, Shenkute TY, Gebisa WC - Diabetes Metab Syndr Obes (2015)

Classification of serum glucose test values of HIV-infected individuals at JUSH comprehensive chronic care and training center, Southwest Ethiopia, 2014.Abbreviations: HIV, human immunodeficiency virus; JUSH, Jimma University Specialized Hospital; IFG, impaired fasting glucose; DM, diabetes mellitus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403746&req=5

f1-dmso-8-197: Classification of serum glucose test values of HIV-infected individuals at JUSH comprehensive chronic care and training center, Southwest Ethiopia, 2014.Abbreviations: HIV, human immunodeficiency virus; JUSH, Jimma University Specialized Hospital; IFG, impaired fasting glucose; DM, diabetes mellitus.
Mentions: The overall prevalence of DM in this study was 6.4% (n=25). Seven of the DM-positive individuals knew about their DM status before our study, and they did not start using drug. Two hundred and ninety-one (74%) and 77 (19.6%) of the study participants had normal glucose value (70–110 mg/dL) and impaired fasting glucose value (111–125 mg/dL), respectively (Figure 1).

Bottom Line: To assess the magnitude of diabetes mellitus (DM) and associated risk factors in human immunodeficiency virus (HIV)-infected individuals.Two hundred and ninety-one (74%) and 77 (19.6%) of the study participants had normal (70-110 mg/dL) and impaired (111-125 mg/dL) fasting blood glucose values, respectively.After adjusting for the other variables, age (adjusted odds ratio [AOR] =4.812, 95% confidence interval [CI]: 1.668-13.881, P=0.004), duration of highly active antiretroviral therapy (HAART) (AOR =26.928, 95% CI: 3.722-194.822, P=0.001), hypertension (AOR =4.779, 95% CI: 1.646-13.874, P=0.004), and low-density lipoprotein cholesterol (AOR =5.669, 95% CI: 1.849-17.382, P=0.004) were significantly associated with DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Laboratory Sciences and Pathology, College of Health Sciences, Jimma University, Jimma, Ethiopia.

ABSTRACT

Background: Globally, diabetes is rising dramatically causing high health burden in low- and middle-income countries. It is estimated that about 382 million people had diabetes in 2013. In 2013, diabetes caused 5.1 million deaths globally. Almost 80% of diabetes deaths occur in low- and middle-income countries.

Purpose: To assess the magnitude of diabetes mellitus (DM) and associated risk factors in human immunodeficiency virus (HIV)-infected individuals.

Methods: An institution-based cross-sectional study was conducted from April to May 2014 at Jimma University Specialized Hospital. Convenient sampling technique was implemented. Sociodemographic and anthropometric data were collected by senior clinical nurses. Venous blood was collected from each study participant. Serum glucose and lipid profile of the study participants was measured using HumaStar 80 spectrophotometer. Data were analyzed using SPSS version 20. Bivariate and multivariate logistic regressions were utilized.

Results: A total of 393 HIV-infected individuals of age ranging from 21 years to 75 years had enrolled in this study. The overall prevalence of DM in this study was 6.4% (n=25). Two hundred and ninety-one (74%) and 77 (19.6%) of the study participants had normal (70-110 mg/dL) and impaired (111-125 mg/dL) fasting blood glucose values, respectively. After adjusting for the other variables, age (adjusted odds ratio [AOR] =4.812, 95% confidence interval [CI]: 1.668-13.881, P=0.004), duration of highly active antiretroviral therapy (HAART) (AOR =26.928, 95% CI: 3.722-194.822, P=0.001), hypertension (AOR =4.779, 95% CI: 1.646-13.874, P=0.004), and low-density lipoprotein cholesterol (AOR =5.669, 95% CI: 1.849-17.382, P=0.004) were significantly associated with DM.

Conclusion: HAART may have an impact on the cause of diabetes. Hence, HIV-infected individuals should be screened for diabetes, both before and after initiation of HAART.

No MeSH data available.


Related in: MedlinePlus