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The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Wang Y, Ma M, Tang Q, Zhu L, Koleini M, Zou D - J Neuroeng Rehabil (2015)

Bottom Line: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups.In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

View Article: PubMed Central - PubMed

Affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. swallow-1113@163.com.

ABSTRACT

Background: After peripheral nerve injury, muscles without innervation begin to undergo atrophy. Research has suggested that MuRf-1 may play a role in muscle atrophy. The neurodynamic mobilization technique (NMT) is a manual therapy method used to elongate a nerve along its long axis, resulting in improved blood flow to the nerve. However, the nerve can be damaged if elongated too much. The purpose of this study is to observe the effect of NMT on muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Methods: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups. Four weeks post-treatment, the wet mass of the tricipital muscles and MuRf-1 expression were observed.

Results: The wet mass of the tricipital muscles in the NMT-B group was significantly greater than the NMT-A, NMT-C, and model groups. In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.

Conclusions: Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

No MeSH data available.


Related in: MedlinePlus

MuRf-1 expression in the triceps in lesion muscles was measured by Western blot. Levels of MuRf-1 in the NMT-B group were reduced compared with all groups except the sham group.
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Fig6: MuRf-1 expression in the triceps in lesion muscles was measured by Western blot. Levels of MuRf-1 in the NMT-B group were reduced compared with all groups except the sham group.

Mentions: MuRf-1 protein expression increased in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except in the sham group (p = 0.197). In the lesioned lateral muscle, MuRf-1 protein expression was lower in the NMT-A and NMT-B groups compared to the model group (p < 0.05); whereas no significant difference was observed between the model and NMT-C groups (p > 0.05). MuRf-1 protein expression was reduced in the NMT-B group compared to the NMT-A and NMT-C groups (p < 0.05) (Table 3 and Figures 5 and 6).Table 3


The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Wang Y, Ma M, Tang Q, Zhu L, Koleini M, Zou D - J Neuroeng Rehabil (2015)

MuRf-1 expression in the triceps in lesion muscles was measured by Western blot. Levels of MuRf-1 in the NMT-B group were reduced compared with all groups except the sham group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403708&req=5

Fig6: MuRf-1 expression in the triceps in lesion muscles was measured by Western blot. Levels of MuRf-1 in the NMT-B group were reduced compared with all groups except the sham group.
Mentions: MuRf-1 protein expression increased in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except in the sham group (p = 0.197). In the lesioned lateral muscle, MuRf-1 protein expression was lower in the NMT-A and NMT-B groups compared to the model group (p < 0.05); whereas no significant difference was observed between the model and NMT-C groups (p > 0.05). MuRf-1 protein expression was reduced in the NMT-B group compared to the NMT-A and NMT-C groups (p < 0.05) (Table 3 and Figures 5 and 6).Table 3

Bottom Line: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups.In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

View Article: PubMed Central - PubMed

Affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. swallow-1113@163.com.

ABSTRACT

Background: After peripheral nerve injury, muscles without innervation begin to undergo atrophy. Research has suggested that MuRf-1 may play a role in muscle atrophy. The neurodynamic mobilization technique (NMT) is a manual therapy method used to elongate a nerve along its long axis, resulting in improved blood flow to the nerve. However, the nerve can be damaged if elongated too much. The purpose of this study is to observe the effect of NMT on muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Methods: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups. Four weeks post-treatment, the wet mass of the tricipital muscles and MuRf-1 expression were observed.

Results: The wet mass of the tricipital muscles in the NMT-B group was significantly greater than the NMT-A, NMT-C, and model groups. In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.

Conclusions: Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

No MeSH data available.


Related in: MedlinePlus