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The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Wang Y, Ma M, Tang Q, Zhu L, Koleini M, Zou D - J Neuroeng Rehabil (2015)

Bottom Line: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups.In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

View Article: PubMed Central - PubMed

Affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. swallow-1113@163.com.

ABSTRACT

Background: After peripheral nerve injury, muscles without innervation begin to undergo atrophy. Research has suggested that MuRf-1 may play a role in muscle atrophy. The neurodynamic mobilization technique (NMT) is a manual therapy method used to elongate a nerve along its long axis, resulting in improved blood flow to the nerve. However, the nerve can be damaged if elongated too much. The purpose of this study is to observe the effect of NMT on muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Methods: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups. Four weeks post-treatment, the wet mass of the tricipital muscles and MuRf-1 expression were observed.

Results: The wet mass of the tricipital muscles in the NMT-B group was significantly greater than the NMT-A, NMT-C, and model groups. In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.

Conclusions: Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

No MeSH data available.


Related in: MedlinePlus

Wet mass of bilateral tricipital muscles. A significant reduction in the tricipital muscle wet mass was noted in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except the sham group (p > 0.05).In the lesioned lateral, the tricipital muscle wet mass in the NMT-B group was significantly increased compared with the NMT-A, NMT-C and model groups (p < 0.05).
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Fig4: Wet mass of bilateral tricipital muscles. A significant reduction in the tricipital muscle wet mass was noted in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except the sham group (p > 0.05).In the lesioned lateral, the tricipital muscle wet mass in the NMT-B group was significantly increased compared with the NMT-A, NMT-C and model groups (p < 0.05).

Mentions: The wet mass of the tricipital muscle was significantly less in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except the sham group (p = 0.289). Further, the tricipital muscle wet mass in the NMT-A and NMT-B groups was significantly increased compared to the model group (p < 0.05), whereas no significant difference was noted between the model and NMT-C groups (p > 0.05). The tricipital muscle wet mass in the NMT-B group was significantly higher than the NMT-A and NMT-C groups (Table 2 and Figure 4).Table 2


The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Wang Y, Ma M, Tang Q, Zhu L, Koleini M, Zou D - J Neuroeng Rehabil (2015)

Wet mass of bilateral tricipital muscles. A significant reduction in the tricipital muscle wet mass was noted in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except the sham group (p > 0.05).In the lesioned lateral, the tricipital muscle wet mass in the NMT-B group was significantly increased compared with the NMT-A, NMT-C and model groups (p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4403708&req=5

Fig4: Wet mass of bilateral tricipital muscles. A significant reduction in the tricipital muscle wet mass was noted in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except the sham group (p > 0.05).In the lesioned lateral, the tricipital muscle wet mass in the NMT-B group was significantly increased compared with the NMT-A, NMT-C and model groups (p < 0.05).
Mentions: The wet mass of the tricipital muscle was significantly less in the lesioned lateral muscle compared with the normal lateral muscle in all groups (p < 0.05) except the sham group (p = 0.289). Further, the tricipital muscle wet mass in the NMT-A and NMT-B groups was significantly increased compared to the model group (p < 0.05), whereas no significant difference was noted between the model and NMT-C groups (p > 0.05). The tricipital muscle wet mass in the NMT-B group was significantly higher than the NMT-A and NMT-C groups (Table 2 and Figure 4).Table 2

Bottom Line: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups.In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

View Article: PubMed Central - PubMed

Affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. swallow-1113@163.com.

ABSTRACT

Background: After peripheral nerve injury, muscles without innervation begin to undergo atrophy. Research has suggested that MuRf-1 may play a role in muscle atrophy. The neurodynamic mobilization technique (NMT) is a manual therapy method used to elongate a nerve along its long axis, resulting in improved blood flow to the nerve. However, the nerve can be damaged if elongated too much. The purpose of this study is to observe the effect of NMT on muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.

Methods: Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups. Four weeks post-treatment, the wet mass of the tricipital muscles and MuRf-1 expression were observed.

Results: The wet mass of the tricipital muscles in the NMT-B group was significantly greater than the NMT-A, NMT-C, and model groups. In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.

Conclusions: Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.

No MeSH data available.


Related in: MedlinePlus