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Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.

Koeda M, Watanabe A, Tsuda K, Matsumoto M, Ikeda Y, Kim W, Tateno A, Naing BT, Karibe H, Shimada T, Suzuki H, Matsuura M, Okubo Y - Front Behav Neurosci (2015)

Bottom Line: The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG).This result suggests that rs7794745 genotype affects voice-specific brain function.Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.

ABSTRACT
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.

No MeSH data available.


CNTNAP2 (rs7794745) effect on cerebral response to language processing. The results of the main effect of rs7794745 (A/A or A/T) in the analysis of full factorial design are shown. The error bar shows the distribution of beta values of cerebral activation under rSEN minus baseline (mean: black squares; dashed line) and under SEN minus baseline (mean: black triangles; line) at the peak coordinates with the main effect of rs7794745 (A/A or A/T). Significant difference was observed in right MFG. Abbreviations: R, right hemisphere; MFG, middle frontal gyrus.
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Figure 5: CNTNAP2 (rs7794745) effect on cerebral response to language processing. The results of the main effect of rs7794745 (A/A or A/T) in the analysis of full factorial design are shown. The error bar shows the distribution of beta values of cerebral activation under rSEN minus baseline (mean: black squares; dashed line) and under SEN minus baseline (mean: black triangles; line) at the peak coordinates with the main effect of rs7794745 (A/A or A/T). Significant difference was observed in right MFG. Abbreviations: R, right hemisphere; MFG, middle frontal gyrus.

Mentions: In order to investigate the genetic effects on cerebral activation in language processing, fMRI data were analyzed based on the 2 × 2 × 2 full factorial design with the three factors: rs7794745 (A/A or A/T), rs2710102 [G/G or A carriers (G/A and A/A)], and task (rSEN or SEN) [voxel level: p < 0.001, cluster level p < 0.05 corrected for multiple comparisons, Monte–Carlo simulation (n = 1000)]. Main effect of rs7794745 (A/A or A/T) was significantly observed in R MFG (voxel level: p < 0.005, cluster level p < 0.05 corrected) (Figure 5 and Table 3C), whereas main effect of rs2710102 [G/G, or A carriers (G/A and A/A)] was not significantly different.


Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.

Koeda M, Watanabe A, Tsuda K, Matsumoto M, Ikeda Y, Kim W, Tateno A, Naing BT, Karibe H, Shimada T, Suzuki H, Matsuura M, Okubo Y - Front Behav Neurosci (2015)

CNTNAP2 (rs7794745) effect on cerebral response to language processing. The results of the main effect of rs7794745 (A/A or A/T) in the analysis of full factorial design are shown. The error bar shows the distribution of beta values of cerebral activation under rSEN minus baseline (mean: black squares; dashed line) and under SEN minus baseline (mean: black triangles; line) at the peak coordinates with the main effect of rs7794745 (A/A or A/T). Significant difference was observed in right MFG. Abbreviations: R, right hemisphere; MFG, middle frontal gyrus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403548&req=5

Figure 5: CNTNAP2 (rs7794745) effect on cerebral response to language processing. The results of the main effect of rs7794745 (A/A or A/T) in the analysis of full factorial design are shown. The error bar shows the distribution of beta values of cerebral activation under rSEN minus baseline (mean: black squares; dashed line) and under SEN minus baseline (mean: black triangles; line) at the peak coordinates with the main effect of rs7794745 (A/A or A/T). Significant difference was observed in right MFG. Abbreviations: R, right hemisphere; MFG, middle frontal gyrus.
Mentions: In order to investigate the genetic effects on cerebral activation in language processing, fMRI data were analyzed based on the 2 × 2 × 2 full factorial design with the three factors: rs7794745 (A/A or A/T), rs2710102 [G/G or A carriers (G/A and A/A)], and task (rSEN or SEN) [voxel level: p < 0.001, cluster level p < 0.05 corrected for multiple comparisons, Monte–Carlo simulation (n = 1000)]. Main effect of rs7794745 (A/A or A/T) was significantly observed in R MFG (voxel level: p < 0.005, cluster level p < 0.05 corrected) (Figure 5 and Table 3C), whereas main effect of rs2710102 [G/G, or A carriers (G/A and A/A)] was not significantly different.

Bottom Line: The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG).This result suggests that rs7794745 genotype affects voice-specific brain function.Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.

ABSTRACT
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.

No MeSH data available.