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Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.

Koeda M, Watanabe A, Tsuda K, Matsumoto M, Ikeda Y, Kim W, Tateno A, Naing BT, Karibe H, Shimada T, Suzuki H, Matsuura M, Okubo Y - Front Behav Neurosci (2015)

Bottom Line: The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG).This result suggests that rs7794745 genotype affects voice-specific brain function.Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.

ABSTRACT
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.

No MeSH data available.


CNTNAP2 (rs7794745) effect on cerebral response to human voice perception. The results of the main effect of rs7794745 in the analysis of full factorial design are shown (voxel level: p < 0.001, cluster level: p < 0.05/3, Monte–Carlo simulation). The error bar shows the distribution of beta values in cerebral activation under rSEN minus baseline (mean: black squares, line) and under SND minus baseline (mean: black triangles, dashed line) at the peak coordinates with the main effect of rs7794745. Asterisks (*) show significant differences with Bonferroni correction in the 3 ROIs (p < 0.05/3). Abbreviations: L, left hemisphere; R, right hemisphere; MFG, middle frontal gyrus; STG, superior temporal gyrus.
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Figure 4: CNTNAP2 (rs7794745) effect on cerebral response to human voice perception. The results of the main effect of rs7794745 in the analysis of full factorial design are shown (voxel level: p < 0.001, cluster level: p < 0.05/3, Monte–Carlo simulation). The error bar shows the distribution of beta values in cerebral activation under rSEN minus baseline (mean: black squares, line) and under SND minus baseline (mean: black triangles, dashed line) at the peak coordinates with the main effect of rs7794745. Asterisks (*) show significant differences with Bonferroni correction in the 3 ROIs (p < 0.05/3). Abbreviations: L, left hemisphere; R, right hemisphere; MFG, middle frontal gyrus; STG, superior temporal gyrus.

Mentions: In order to examine the genetic effects on cerebral response to human voice perception, fMRI data were analyzed based on the 2 × 2 × 2 full factorial design with the three factors: rs7794745 (A/A or A/T), rs2710102 [G/G, or A carriers (G/A and A/A)], and task (rSEN or SND) [voxel level: p < 0.001, cluster level p < 0.05 corrected for multiple comparisons, Monte–Carlo simulation (n = 1000)]. Main effect of rs7794745 (A/A or A/T) was significantly observed in bilateral STG and R MFG (voxel level: p < 0.005, cluster level p < 0.05 corrected) (Figure 4 and Table 3B), whereas main effect of rs2710102 [G/G, or A carriers (G/A and A/A)] was not significantly different. From the results of main effect of rs7794745, ROIs were set on 3 regions: L STG [−54, −30, 6], R STG [56, −24, 4], and R MFG [46, 48, 0]. In these ROIs, beta values under rSEN or SND conditions were calculated by using rfxplot (Glascher, 2009). In Figure 4, cerebral activations between rSEN and SND were compared by Wilcoxon Signed Rank Test. In rs7794745 A/A, the beta values of rSEN were significantly greater than those of SND [L STG: Z = −3.01, p = 0.002 (p < 0.05/3); R STG: Z = −4.38, p < 0.001 (p < 0.05/3); R MFG: −3.33, p = 0.001, (p < 0.05/3)], whereas in rs7794745 A/T, the beta values were not significantly different between rSEN and SND (L STG: Z = −0.39, p > 0.05/3; R STG: Z = −1.90, p > 0.05/3; R MFG: Z = −0.17, p > 0.05/3).


Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.

Koeda M, Watanabe A, Tsuda K, Matsumoto M, Ikeda Y, Kim W, Tateno A, Naing BT, Karibe H, Shimada T, Suzuki H, Matsuura M, Okubo Y - Front Behav Neurosci (2015)

CNTNAP2 (rs7794745) effect on cerebral response to human voice perception. The results of the main effect of rs7794745 in the analysis of full factorial design are shown (voxel level: p < 0.001, cluster level: p < 0.05/3, Monte–Carlo simulation). The error bar shows the distribution of beta values in cerebral activation under rSEN minus baseline (mean: black squares, line) and under SND minus baseline (mean: black triangles, dashed line) at the peak coordinates with the main effect of rs7794745. Asterisks (*) show significant differences with Bonferroni correction in the 3 ROIs (p < 0.05/3). Abbreviations: L, left hemisphere; R, right hemisphere; MFG, middle frontal gyrus; STG, superior temporal gyrus.
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Related In: Results  -  Collection

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Figure 4: CNTNAP2 (rs7794745) effect on cerebral response to human voice perception. The results of the main effect of rs7794745 in the analysis of full factorial design are shown (voxel level: p < 0.001, cluster level: p < 0.05/3, Monte–Carlo simulation). The error bar shows the distribution of beta values in cerebral activation under rSEN minus baseline (mean: black squares, line) and under SND minus baseline (mean: black triangles, dashed line) at the peak coordinates with the main effect of rs7794745. Asterisks (*) show significant differences with Bonferroni correction in the 3 ROIs (p < 0.05/3). Abbreviations: L, left hemisphere; R, right hemisphere; MFG, middle frontal gyrus; STG, superior temporal gyrus.
Mentions: In order to examine the genetic effects on cerebral response to human voice perception, fMRI data were analyzed based on the 2 × 2 × 2 full factorial design with the three factors: rs7794745 (A/A or A/T), rs2710102 [G/G, or A carriers (G/A and A/A)], and task (rSEN or SND) [voxel level: p < 0.001, cluster level p < 0.05 corrected for multiple comparisons, Monte–Carlo simulation (n = 1000)]. Main effect of rs7794745 (A/A or A/T) was significantly observed in bilateral STG and R MFG (voxel level: p < 0.005, cluster level p < 0.05 corrected) (Figure 4 and Table 3B), whereas main effect of rs2710102 [G/G, or A carriers (G/A and A/A)] was not significantly different. From the results of main effect of rs7794745, ROIs were set on 3 regions: L STG [−54, −30, 6], R STG [56, −24, 4], and R MFG [46, 48, 0]. In these ROIs, beta values under rSEN or SND conditions were calculated by using rfxplot (Glascher, 2009). In Figure 4, cerebral activations between rSEN and SND were compared by Wilcoxon Signed Rank Test. In rs7794745 A/A, the beta values of rSEN were significantly greater than those of SND [L STG: Z = −3.01, p = 0.002 (p < 0.05/3); R STG: Z = −4.38, p < 0.001 (p < 0.05/3); R MFG: −3.33, p = 0.001, (p < 0.05/3)], whereas in rs7794745 A/T, the beta values were not significantly different between rSEN and SND (L STG: Z = −0.39, p > 0.05/3; R STG: Z = −1.90, p > 0.05/3; R MFG: Z = −0.17, p > 0.05/3).

Bottom Line: The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG).This result suggests that rs7794745 genotype affects voice-specific brain function.Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.

ABSTRACT
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.

No MeSH data available.