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Immunoglobulin G4-related disease (IgG4-RD) in the orbit: mucosa-associated lymphoid tissue (MALT)-type lymphomas.

Oleś K, Składzień J, Szczepański W, Okoń K, Leszczyńska J, Bojanowska E, Bartuś K, Mika J - Med. Sci. Monit. (2015)

Bottom Line: The starting study population consisted of 167 patients with isolated infiltrative tumor diseases within the orbital region treated at the Department of Otolaryngology, Head and Neck Surgery of the Medical College Jagiellonian University in Cracow.The immunohistochemical assays using anti-IgG, anti-IgG4 and anti-CD138 antibodies were used to estimate the IgG4+/CD138+ and IgG4+/IgG+ ratios.In this study, results consistent with the criteria of IgG4-related disease were obtained in approximately 50% patients with immunohistochemical diagnosis of orbital MALT lymphoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Medical College Jagiellonian University, Cracow, Poland.

ABSTRACT

Background: MALT lymphomas were classified for differential diagnostics of IgG4-dependent disease due to their exceptional predilection to intraorbital localization. Therefore, the goal of our studies was large retrospective analysis of patients diagnosed with MALT lymphomas within the orbital tissues, since no such studies have been conducted in Poland.

Material/methods: The starting study population consisted of 167 patients with isolated infiltrative tumor diseases within the orbital region treated at the Department of Otolaryngology, Head and Neck Surgery of the Medical College Jagiellonian University in Cracow. The immunohistochemical assays using anti-IgG, anti-IgG4 and anti-CD138 antibodies were used to estimate the IgG4+/CD138+ and IgG4+/IgG+ ratios.

Results: Of all the studied and analyzed patients, a final group of 19 patients with orbital MALT lymphomas was selected to undergo diagnostic examinations for IgG4-related disease. Detailed analysis and diagnostic screening for IgG4-related disease was performed and results meeting the criteria of IgG4-dependent disease were obtained in 10 out of 19 patients with the diagnosis of MALT tumor established on the basis of immunohistochemical assays.

Conclusions: MALT lymphomas are the most common of all lymphomas occurring within orbital tissues. In this study, results consistent with the criteria of IgG4-related disease were obtained in approximately 50% patients with immunohistochemical diagnosis of orbital MALT lymphoma.

No MeSH data available.


Related in: MedlinePlus

An in-detail analysis of gender of all 167 patients undergoing surgeries for orbital tumors in years 2002–2012 (A) and of the 19 patients diagnosed with orbital MALT lymphoma subjected to immunohistochemical diagnostics for IgG4-related disease – analysis of gender (B) and tumor location (C).
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f3-medscimonit-21-1043: An in-detail analysis of gender of all 167 patients undergoing surgeries for orbital tumors in years 2002–2012 (A) and of the 19 patients diagnosed with orbital MALT lymphoma subjected to immunohistochemical diagnostics for IgG4-related disease – analysis of gender (B) and tumor location (C).

Mentions: We have analyses of patients diagnosed with MALT lymphomas, performed with histological and immunohistochemical differentiation of cases depending on the assessed status of IgG4-positive plasma cells. A detailed analysis of the gender of all 167 patients undergoing surgery for orbital tumors in years 2002–2012 revealed that non-malignant lesions were predominant in women (66%) compared to men (34%) (Figure 3A). Of all the studied and analyzed patients, a final group of 19 patients with orbital MALT lymphomas was selected to undergo diagnostic examinations for IgG4-related disease. A similar incidence was observed in patients of both genders diagnosed with MALT IgG4+ lymphomas, while a predominance of women was observed in the IgG4− group (Figure 3B). No significant differences were observed in relation to the affected orbit side (Figure 3C).


Immunoglobulin G4-related disease (IgG4-RD) in the orbit: mucosa-associated lymphoid tissue (MALT)-type lymphomas.

Oleś K, Składzień J, Szczepański W, Okoń K, Leszczyńska J, Bojanowska E, Bartuś K, Mika J - Med. Sci. Monit. (2015)

An in-detail analysis of gender of all 167 patients undergoing surgeries for orbital tumors in years 2002–2012 (A) and of the 19 patients diagnosed with orbital MALT lymphoma subjected to immunohistochemical diagnostics for IgG4-related disease – analysis of gender (B) and tumor location (C).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4403377&req=5

f3-medscimonit-21-1043: An in-detail analysis of gender of all 167 patients undergoing surgeries for orbital tumors in years 2002–2012 (A) and of the 19 patients diagnosed with orbital MALT lymphoma subjected to immunohistochemical diagnostics for IgG4-related disease – analysis of gender (B) and tumor location (C).
Mentions: We have analyses of patients diagnosed with MALT lymphomas, performed with histological and immunohistochemical differentiation of cases depending on the assessed status of IgG4-positive plasma cells. A detailed analysis of the gender of all 167 patients undergoing surgery for orbital tumors in years 2002–2012 revealed that non-malignant lesions were predominant in women (66%) compared to men (34%) (Figure 3A). Of all the studied and analyzed patients, a final group of 19 patients with orbital MALT lymphomas was selected to undergo diagnostic examinations for IgG4-related disease. A similar incidence was observed in patients of both genders diagnosed with MALT IgG4+ lymphomas, while a predominance of women was observed in the IgG4− group (Figure 3B). No significant differences were observed in relation to the affected orbit side (Figure 3C).

Bottom Line: The starting study population consisted of 167 patients with isolated infiltrative tumor diseases within the orbital region treated at the Department of Otolaryngology, Head and Neck Surgery of the Medical College Jagiellonian University in Cracow.The immunohistochemical assays using anti-IgG, anti-IgG4 and anti-CD138 antibodies were used to estimate the IgG4+/CD138+ and IgG4+/IgG+ ratios.In this study, results consistent with the criteria of IgG4-related disease were obtained in approximately 50% patients with immunohistochemical diagnosis of orbital MALT lymphoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Medical College Jagiellonian University, Cracow, Poland.

ABSTRACT

Background: MALT lymphomas were classified for differential diagnostics of IgG4-dependent disease due to their exceptional predilection to intraorbital localization. Therefore, the goal of our studies was large retrospective analysis of patients diagnosed with MALT lymphomas within the orbital tissues, since no such studies have been conducted in Poland.

Material/methods: The starting study population consisted of 167 patients with isolated infiltrative tumor diseases within the orbital region treated at the Department of Otolaryngology, Head and Neck Surgery of the Medical College Jagiellonian University in Cracow. The immunohistochemical assays using anti-IgG, anti-IgG4 and anti-CD138 antibodies were used to estimate the IgG4+/CD138+ and IgG4+/IgG+ ratios.

Results: Of all the studied and analyzed patients, a final group of 19 patients with orbital MALT lymphomas was selected to undergo diagnostic examinations for IgG4-related disease. Detailed analysis and diagnostic screening for IgG4-related disease was performed and results meeting the criteria of IgG4-dependent disease were obtained in 10 out of 19 patients with the diagnosis of MALT tumor established on the basis of immunohistochemical assays.

Conclusions: MALT lymphomas are the most common of all lymphomas occurring within orbital tissues. In this study, results consistent with the criteria of IgG4-related disease were obtained in approximately 50% patients with immunohistochemical diagnosis of orbital MALT lymphoma.

No MeSH data available.


Related in: MedlinePlus