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Flavonoids from Salvia chloroleuca with α-Amylsae and α-Glucosidase Inhibitory Effect.

Asghari B, Salehi P, Sonboli A, Nejad Ebrahimi S - Iran J Pharm Res (2015)

Bottom Line: In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca.Compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 µM, respectively.Also these compounds exhibited moderate α-amylase activity with IC50 values 81.7, 61.5, and 76.3 µM, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Plant Production and Breeding, Faculty of Engineering and Technology, Imam Khomeini International University, Qazvin, Iran. ; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.

ABSTRACT
It is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca. The inhibitory activity of these compounds against α-amylase and α-glucosidase were evaluated. Compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 µM, respectively. Also these compounds exhibited moderate α-amylase activity with IC50 values 81.7, 61.5, and 76.3 µM, respectively.

No MeSH data available.


Related in: MedlinePlus

Chemical structures of isolated compounds.
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Figure 2: Chemical structures of isolated compounds.

Mentions: Bio-assay guided fractionation of active extracts led to the isolation of luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), and diosmetin 7-O-glucuronide (3) as active compounds of methanolic extract, whereas salvigenin (4) was the major compound isolated from n-hexane extract. Isolated compounds were identified by ESI-MS, 1D and 2D NMR spectroscopy, and by comparison with published data (19-22). Chemical structures of the compounds are shown in Figure 2.


Flavonoids from Salvia chloroleuca with α-Amylsae and α-Glucosidase Inhibitory Effect.

Asghari B, Salehi P, Sonboli A, Nejad Ebrahimi S - Iran J Pharm Res (2015)

Chemical structures of isolated compounds.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403079&req=5

Figure 2: Chemical structures of isolated compounds.
Mentions: Bio-assay guided fractionation of active extracts led to the isolation of luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), and diosmetin 7-O-glucuronide (3) as active compounds of methanolic extract, whereas salvigenin (4) was the major compound isolated from n-hexane extract. Isolated compounds were identified by ESI-MS, 1D and 2D NMR spectroscopy, and by comparison with published data (19-22). Chemical structures of the compounds are shown in Figure 2.

Bottom Line: In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca.Compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 µM, respectively.Also these compounds exhibited moderate α-amylase activity with IC50 values 81.7, 61.5, and 76.3 µM, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Plant Production and Breeding, Faculty of Engineering and Technology, Imam Khomeini International University, Qazvin, Iran. ; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.

ABSTRACT
It is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca. The inhibitory activity of these compounds against α-amylase and α-glucosidase were evaluated. Compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 µM, respectively. Also these compounds exhibited moderate α-amylase activity with IC50 values 81.7, 61.5, and 76.3 µM, respectively.

No MeSH data available.


Related in: MedlinePlus