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Development of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, diphenhydramine and pseudoephedrine in tablets.

Souri E, Rahimi A, Shabani Ravari N, Barazandeh Tehrani M - Iran J Pharm Res (2015)

Bottom Line: A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold.The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively.The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was performed using the (1)D value of acetaminophen at 281.5 nm, (2)D value of diphenhydramine hydrochloride at 226.0 nm and (4)D value of pseudoephedrine hydrochloride at 218.0 nm. The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%). The developed method was used for simultaneous determination of these drugs in pharmaceutical dosage forms and no interference from excipients was observed.

No MeSH data available.


Related in: MedlinePlus

Second order derivative spectra of (a) acetaminophen (20  g/mL), (b) diphenhydramine hydrochloride (10  g/mL) and (c) pseudoephedrine hydrochloride (7  g/mL).
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Figure 4: Second order derivative spectra of (a) acetaminophen (20  g/mL), (b) diphenhydramine hydrochloride (10  g/mL) and (c) pseudoephedrine hydrochloride (7  g/mL).

Mentions: The second order derivative and fourth order derivative spectra were also showed suitable wavelength for determination of other drugs. The zero-crossing point for acetaminophen and pseudoephedrine hydrochloride at 226.0 nm in the second order derivative spectra (Figure 4) could be used for the determination of diphenhydramine hydrochloride. Also the zero-crossing point for acetaminophen and diphenhydramine hydrochloride at 218.0 nm in the fourth order derivative spectra (Figure 5) was suitable for quantification of pseudoephedrine hydrochloride. These selected wavelengths, showed the best linear response to the analyte concentration, which was not affected by the concentration of other components.


Development of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, diphenhydramine and pseudoephedrine in tablets.

Souri E, Rahimi A, Shabani Ravari N, Barazandeh Tehrani M - Iran J Pharm Res (2015)

Second order derivative spectra of (a) acetaminophen (20  g/mL), (b) diphenhydramine hydrochloride (10  g/mL) and (c) pseudoephedrine hydrochloride (7  g/mL).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403059&req=5

Figure 4: Second order derivative spectra of (a) acetaminophen (20  g/mL), (b) diphenhydramine hydrochloride (10  g/mL) and (c) pseudoephedrine hydrochloride (7  g/mL).
Mentions: The second order derivative and fourth order derivative spectra were also showed suitable wavelength for determination of other drugs. The zero-crossing point for acetaminophen and pseudoephedrine hydrochloride at 226.0 nm in the second order derivative spectra (Figure 4) could be used for the determination of diphenhydramine hydrochloride. Also the zero-crossing point for acetaminophen and diphenhydramine hydrochloride at 218.0 nm in the fourth order derivative spectra (Figure 5) was suitable for quantification of pseudoephedrine hydrochloride. These selected wavelengths, showed the best linear response to the analyte concentration, which was not affected by the concentration of other components.

Bottom Line: A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold.The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively.The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was performed using the (1)D value of acetaminophen at 281.5 nm, (2)D value of diphenhydramine hydrochloride at 226.0 nm and (4)D value of pseudoephedrine hydrochloride at 218.0 nm. The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%). The developed method was used for simultaneous determination of these drugs in pharmaceutical dosage forms and no interference from excipients was observed.

No MeSH data available.


Related in: MedlinePlus