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Development of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, diphenhydramine and pseudoephedrine in tablets.

Souri E, Rahimi A, Shabani Ravari N, Barazandeh Tehrani M - Iran J Pharm Res (2015)

Bottom Line: A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold.The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively.The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was performed using the (1)D value of acetaminophen at 281.5 nm, (2)D value of diphenhydramine hydrochloride at 226.0 nm and (4)D value of pseudoephedrine hydrochloride at 218.0 nm. The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%). The developed method was used for simultaneous determination of these drugs in pharmaceutical dosage forms and no interference from excipients was observed.

No MeSH data available.


Related in: MedlinePlus

Zero order spectra of (a) acetaminophen (20 μg/mL), (b) diphenhydramine hydrochloride (10 μg/mL) and (c) pseudoephedrine hydrochloride (7 μg/mL).
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Figure 2: Zero order spectra of (a) acetaminophen (20 μg/mL), (b) diphenhydramine hydrochloride (10 μg/mL) and (c) pseudoephedrine hydrochloride (7 μg/mL).

Mentions: The zero order absorption spectra of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride obtained in 0.1 M HCl solution in the presence of 0.1 M HCl as blank are shown in Figure 2. As direct simultaneous measurement of these drugs is not possible, the derivative spectra were examined. The derivative spectra of all three compounds were obtained at different orders and varied Δλ values to select the more suitable order of the derivative for measurements.


Development of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, diphenhydramine and pseudoephedrine in tablets.

Souri E, Rahimi A, Shabani Ravari N, Barazandeh Tehrani M - Iran J Pharm Res (2015)

Zero order spectra of (a) acetaminophen (20 μg/mL), (b) diphenhydramine hydrochloride (10 μg/mL) and (c) pseudoephedrine hydrochloride (7 μg/mL).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4403059&req=5

Figure 2: Zero order spectra of (a) acetaminophen (20 μg/mL), (b) diphenhydramine hydrochloride (10 μg/mL) and (c) pseudoephedrine hydrochloride (7 μg/mL).
Mentions: The zero order absorption spectra of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride obtained in 0.1 M HCl solution in the presence of 0.1 M HCl as blank are shown in Figure 2. As direct simultaneous measurement of these drugs is not possible, the derivative spectra were examined. The derivative spectra of all three compounds were obtained at different orders and varied Δλ values to select the more suitable order of the derivative for measurements.

Bottom Line: A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold.The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively.The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%).

View Article: PubMed Central - PubMed

Affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was performed using the (1)D value of acetaminophen at 281.5 nm, (2)D value of diphenhydramine hydrochloride at 226.0 nm and (4)D value of pseudoephedrine hydrochloride at 218.0 nm. The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 µg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2.2% and error<3%). The developed method was used for simultaneous determination of these drugs in pharmaceutical dosage forms and no interference from excipients was observed.

No MeSH data available.


Related in: MedlinePlus