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Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BE - J Clin Med (2015)

Bottom Line: We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD).Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included.Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

ABSTRACT
We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included. A 6-level severity scale including no drusen, 4 levels of increasing area (from minimal [<2596 μm(2)] to large [>9086 μm(2)]) of only small hard drusen, and intermediate drusen was used. The 5-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (P<.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (P<0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

No MeSH data available.


Related in: MedlinePlus

Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by CFH Y402H (rs1061170) genotype and severity level at the beginning of the interval.
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Figure 4: Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by CFH Y402H (rs1061170) genotype and severity level at the beginning of the interval.

Mentions: Figures 4-5 and Tables S1-S6 show the relationships of the CFH and ARMS2 candidate genes stratified by drusen severity levels at the beginning of an interval to the 5-year incidences for each drusen severity level and AMD outcome. While few individuals had 2 risk alleles, especially for ARMS2, the increasing incidence was still apparent and statistically significant for some relationships. For CFH Y402H genotype (Figure 3), the strongest associations for incidence of Level 6 (Table S5) and incidence of any AMD (Table S6) occurred when the initial severity was at least Level 4. Incidence of Level 6 was about 9-10% regardless of the number of risk alleles for CFH Y402H (P=0.35 for any differences after adjusting for age and sex) when initial drusen severity was Level 3 but ranged from 14% to 25% for 0 vs. 2 risk alleles when the initial severity was Level 5 (OR=1.4 per risk allele, P<0.001 after adjusting for age and sex). Where an association with CFH was present, the association was stronger in individuals with 2 risk alleles compared to individuals with only 1 risk allele.


Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BE - J Clin Med (2015)

Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by CFH Y402H (rs1061170) genotype and severity level at the beginning of the interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402933&req=5

Figure 4: Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by CFH Y402H (rs1061170) genotype and severity level at the beginning of the interval.
Mentions: Figures 4-5 and Tables S1-S6 show the relationships of the CFH and ARMS2 candidate genes stratified by drusen severity levels at the beginning of an interval to the 5-year incidences for each drusen severity level and AMD outcome. While few individuals had 2 risk alleles, especially for ARMS2, the increasing incidence was still apparent and statistically significant for some relationships. For CFH Y402H genotype (Figure 3), the strongest associations for incidence of Level 6 (Table S5) and incidence of any AMD (Table S6) occurred when the initial severity was at least Level 4. Incidence of Level 6 was about 9-10% regardless of the number of risk alleles for CFH Y402H (P=0.35 for any differences after adjusting for age and sex) when initial drusen severity was Level 3 but ranged from 14% to 25% for 0 vs. 2 risk alleles when the initial severity was Level 5 (OR=1.4 per risk allele, P<0.001 after adjusting for age and sex). Where an association with CFH was present, the association was stronger in individuals with 2 risk alleles compared to individuals with only 1 risk allele.

Bottom Line: We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD).Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included.Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

ABSTRACT
We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included. A 6-level severity scale including no drusen, 4 levels of increasing area (from minimal [<2596 μm(2)] to large [>9086 μm(2)]) of only small hard drusen, and intermediate drusen was used. The 5-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (P<.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (P<0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

No MeSH data available.


Related in: MedlinePlus