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Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BE - J Clin Med (2015)

Bottom Line: We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD).Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included.Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

ABSTRACT
We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included. A 6-level severity scale including no drusen, 4 levels of increasing area (from minimal [<2596 μm(2)] to large [>9086 μm(2)]) of only small hard drusen, and intermediate drusen was used. The 5-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (P<.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (P<0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

No MeSH data available.


Related in: MedlinePlus

Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by age group (<60, 60-69, and ≥70 years) and severity level at the beginning of the interval.
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Figure 2: Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by age group (<60, 60-69, and ≥70 years) and severity level at the beginning of the interval.

Mentions: Figures 2-5 and Tables S1-S6 show the relationships between drusen severity level and AMD status at follow-up by age, sex and genetic information, stratified by initial drusen level. Figure 2 shows the distribution of the follow-up drusen severity level and AMD status by age group. Odds ratios for these relationships are presented in Tables S1-S6, with each possible outcome in a separate table. Older age was associated with higher 5-year incidence of most outcomes and the associations were stronger in eyes with larger areas of small hard drusen and more severe lesions. Sex was not associated with the development of any drusen outcome (Figure 3).


Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BE - J Clin Med (2015)

Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by age group (<60, 60-69, and ≥70 years) and severity level at the beginning of the interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402933&req=5

Figure 2: Five-year incidence of increasing area of small hard drusen, intermediate drusen, and any AMD by age group (<60, 60-69, and ≥70 years) and severity level at the beginning of the interval.
Mentions: Figures 2-5 and Tables S1-S6 show the relationships between drusen severity level and AMD status at follow-up by age, sex and genetic information, stratified by initial drusen level. Figure 2 shows the distribution of the follow-up drusen severity level and AMD status by age group. Odds ratios for these relationships are presented in Tables S1-S6, with each possible outcome in a separate table. Older age was associated with higher 5-year incidence of most outcomes and the associations were stronger in eyes with larger areas of small hard drusen and more severe lesions. Sex was not associated with the development of any drusen outcome (Figure 3).

Bottom Line: We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD).Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included.Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

ABSTRACT
We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included. A 6-level severity scale including no drusen, 4 levels of increasing area (from minimal [<2596 μm(2)] to large [>9086 μm(2)]) of only small hard drusen, and intermediate drusen was used. The 5-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (P<.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (P<0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

No MeSH data available.


Related in: MedlinePlus