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Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BE - J Clin Med (2015)

Bottom Line: We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD).Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included.Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

ABSTRACT
We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included. A 6-level severity scale including no drusen, 4 levels of increasing area (from minimal [<2596 μm(2)] to large [>9086 μm(2)]) of only small hard drusen, and intermediate drusen was used. The 5-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (P<.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (P<0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

No MeSH data available.


Related in: MedlinePlus

The relationship of no drusen, 4 areas of increasing involvement of the macula by small hard drusen and intermediate drusen to the 5-year incidence of more severe levels of drusen and any AMD in the Beaver Dam Eye Study, 1988-1990 to 2008-2010.
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Figure 1: The relationship of no drusen, 4 areas of increasing involvement of the macula by small hard drusen and intermediate drusen to the 5-year incidence of more severe levels of drusen and any AMD in the Beaver Dam Eye Study, 1988-1990 to 2008-2010.

Mentions: Figure 1 shows the distribution of drusen severity levels at the follow-up examination for each level at the start of the interval and Table 2 shows the results of incidence analyses for each drusen severity level. As severity level at the beginning of an interval increased, so did the development of the more severe drusen levels (Figure 1). For example, 8% of eyes with Level 1 (n=2206) at the start of a 5-year follow-up interval developed Level 5 or worse compared with 25% of eyes starting at Level 4 (n=2370). 49% of eyes with Level 1 (n=2206) developed Level 2 or worse by the end of a 5-year period, and 36% of eyes with Level 3 (n=2515) developed Level 4 or worse.


Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study.

Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BE - J Clin Med (2015)

The relationship of no drusen, 4 areas of increasing involvement of the macula by small hard drusen and intermediate drusen to the 5-year incidence of more severe levels of drusen and any AMD in the Beaver Dam Eye Study, 1988-1990 to 2008-2010.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402933&req=5

Figure 1: The relationship of no drusen, 4 areas of increasing involvement of the macula by small hard drusen and intermediate drusen to the 5-year incidence of more severe levels of drusen and any AMD in the Beaver Dam Eye Study, 1988-1990 to 2008-2010.
Mentions: Figure 1 shows the distribution of drusen severity levels at the follow-up examination for each level at the start of the interval and Table 2 shows the results of incidence analyses for each drusen severity level. As severity level at the beginning of an interval increased, so did the development of the more severe drusen levels (Figure 1). For example, 8% of eyes with Level 1 (n=2206) at the start of a 5-year follow-up interval developed Level 5 or worse compared with 25% of eyes starting at Level 4 (n=2370). 49% of eyes with Level 1 (n=2206) developed Level 2 or worse by the end of a 5-year period, and 36% of eyes with Level 3 (n=2515) developed Level 4 or worse.

Bottom Line: We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD).Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included.Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

ABSTRACT
We tested the hypothesis that large areas of small hard drusen (diameter <63 μm) and intermediate drusen (diameter 63-124 μm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least 2 consecutive visits spaced 5 years apart over a 20-year period were included. A 6-level severity scale including no drusen, 4 levels of increasing area (from minimal [<2596 μm(2)] to large [>9086 μm(2)]) of only small hard drusen, and intermediate drusen was used. The 5-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (P<.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (P<0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD.

No MeSH data available.


Related in: MedlinePlus