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New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity.

Wang Y, Zhang L, Wang F, Li ZH, Dong ZJ, Liu JK - Nat Prod Bioprospect (2015)

Bottom Line: One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms.The new compounds were elucidated based on their spectroscopic data.This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

ABSTRACT

One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

No MeSH data available.


Structures of compounds 1–6
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Fig1: Structures of compounds 1–6

Mentions: In order to search for more novel and potentially bioactive secondary metabolites, the chemical constituents of E. goetzii cultures were investigated by altering the culture conditions of the fungus and enlarging the fermentation scale. This investigation led to the isolation and identification of one new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene named engleromycenol (3), along with three known rosane-type diterpenes: rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) [7]. Their structures (Fig. 1) were elucidated based on the spectroscopic data analyses. The cholesterol ester transfer protein (CETP) inhibition activities of compounds 1–6 were examined and engleromycenolic acid A (1) showed CETP inhibition activity with IC50 value at 7.55 µM.Fig. 1


New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity.

Wang Y, Zhang L, Wang F, Li ZH, Dong ZJ, Liu JK - Nat Prod Bioprospect (2015)

Structures of compounds 1–6
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4402584&req=5

Fig1: Structures of compounds 1–6
Mentions: In order to search for more novel and potentially bioactive secondary metabolites, the chemical constituents of E. goetzii cultures were investigated by altering the culture conditions of the fungus and enlarging the fermentation scale. This investigation led to the isolation and identification of one new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene named engleromycenol (3), along with three known rosane-type diterpenes: rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) [7]. Their structures (Fig. 1) were elucidated based on the spectroscopic data analyses. The cholesterol ester transfer protein (CETP) inhibition activities of compounds 1–6 were examined and engleromycenolic acid A (1) showed CETP inhibition activity with IC50 value at 7.55 µM.Fig. 1

Bottom Line: One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms.The new compounds were elucidated based on their spectroscopic data.This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

ABSTRACT

One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

No MeSH data available.