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New Dimeric and seco-Abietane Diterpenoids from Salvia wardii.

Xiao QL, Xia F, Yang XW, Liao Y, Yang LX, Wei YK, Li X, Xu G - Nat Prod Bioprospect (2015)

Bottom Line: Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.

ABSTRACT

Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

No MeSH data available.


Related in: MedlinePlus

Key HMBC () and 1H-1H COSY () correlations of 2
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Fig2: Key HMBC () and 1H-1H COSY () correlations of 2

Mentions: The molecular formula of salviwardin B (2) was determined to be C40H52O4 from its 13C NMR and HRESIMS spectral data, indicating one more unsaturation than 1. Comparison of their 1D and 2D NMR data indicated that the structures of 1 and 2 were similar to each other (Tables 1, 2). The difference lied in that the two methylenes (C-6′ δC 19.3 and C-7′ δC 32.4) in 1 were replaced by a double bond (C-6′ δC 126.9 and C-7′ δC 128.0) in 2, which indicated that 2 was a 6′,7′-dehydrogen derivative of 1. This was confirmed by HMBC correlations from H-6′ (δH 5.82) to C-4′ (δC 33.3), C-5′ (δC 51.6) and C-8′ (δC 125.8), and from H-7′ (δH 6.37) to C-5′and C-14′ (δC 118.0). By detailed analysis of its ROESY (Fig. 2) spectrum, the relative configuration of 2 was also elucidated to be the same as that of 1. Ultimately, the structure of 2 was determined and named salviwardin B.Fig. 2


New Dimeric and seco-Abietane Diterpenoids from Salvia wardii.

Xiao QL, Xia F, Yang XW, Liao Y, Yang LX, Wei YK, Li X, Xu G - Nat Prod Bioprospect (2015)

Key HMBC () and 1H-1H COSY () correlations of 2
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4402580&req=5

Fig2: Key HMBC () and 1H-1H COSY () correlations of 2
Mentions: The molecular formula of salviwardin B (2) was determined to be C40H52O4 from its 13C NMR and HRESIMS spectral data, indicating one more unsaturation than 1. Comparison of their 1D and 2D NMR data indicated that the structures of 1 and 2 were similar to each other (Tables 1, 2). The difference lied in that the two methylenes (C-6′ δC 19.3 and C-7′ δC 32.4) in 1 were replaced by a double bond (C-6′ δC 126.9 and C-7′ δC 128.0) in 2, which indicated that 2 was a 6′,7′-dehydrogen derivative of 1. This was confirmed by HMBC correlations from H-6′ (δH 5.82) to C-4′ (δC 33.3), C-5′ (δC 51.6) and C-8′ (δC 125.8), and from H-7′ (δH 6.37) to C-5′and C-14′ (δC 118.0). By detailed analysis of its ROESY (Fig. 2) spectrum, the relative configuration of 2 was also elucidated to be the same as that of 1. Ultimately, the structure of 2 was determined and named salviwardin B.Fig. 2

Bottom Line: Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.

ABSTRACT

Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

No MeSH data available.


Related in: MedlinePlus