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New Dimeric and seco-Abietane Diterpenoids from Salvia wardii.

Xiao QL, Xia F, Yang XW, Liao Y, Yang LX, Wei YK, Li X, Xu G - Nat Prod Bioprospect (2015)

Bottom Line: Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.

ABSTRACT

Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

No MeSH data available.


Related in: MedlinePlus

Key HMBC (), 1H-1H COSY (), and ROESY () correlations of 1
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Fig1: Key HMBC (), 1H-1H COSY (), and ROESY () correlations of 1

Mentions: Analysis of the 1D and 2D NMR spectra distinguished two sets of diterpenoid signals, C-1–C-20 and C-1′–C-20′, respectively. According to the characteristic signals for normal abietane diterpenoids at δC 40.1 (s, C-4), δC 46.7 (s, C-10), δC 24.3 (q, C-18), δC 30.8 (q, C-19), δC 24.2 (q, C-20), and an isopropyl group at δC 26.9 (d, C-15), δC 21.5 (q, Me-16), and δC 21.0 (q, Me-17), the structure of unit 1 can be ascribed to be an abietane diterpenoid [21–23]. The HMBC correlations (Fig. 1) from Me-20 (δH 1.40) to C-1 (δC 31.7), C-5 (δC 80.2), C-9 (δC 124.7), and C-10; from Me-18 (δH 1.32) and Me-19 (δH 1.02) to C-3 (δC 38.9), C-4, and C-5; from H-15 (δH 26.9) to C-12 (δC 181.8), C-13 (δC 141.3), and C-14 (δC 135.0); from H-14 (δH 6.55) to C-7 (δC 141.2), C-9, and C-12; and from H-6 (δH 5.42) to C-8 (δC 140.8), together with proton spin systems H-1/H-2/H-3 and H-6/H-7 obtained from the 1H–1H COSY spectrum (Fig. 1), established the structure of the unit 1.Fig. 1


New Dimeric and seco-Abietane Diterpenoids from Salvia wardii.

Xiao QL, Xia F, Yang XW, Liao Y, Yang LX, Wei YK, Li X, Xu G - Nat Prod Bioprospect (2015)

Key HMBC (), 1H-1H COSY (), and ROESY () correlations of 1
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4402580&req=5

Fig1: Key HMBC (), 1H-1H COSY (), and ROESY () correlations of 1
Mentions: Analysis of the 1D and 2D NMR spectra distinguished two sets of diterpenoid signals, C-1–C-20 and C-1′–C-20′, respectively. According to the characteristic signals for normal abietane diterpenoids at δC 40.1 (s, C-4), δC 46.7 (s, C-10), δC 24.3 (q, C-18), δC 30.8 (q, C-19), δC 24.2 (q, C-20), and an isopropyl group at δC 26.9 (d, C-15), δC 21.5 (q, Me-16), and δC 21.0 (q, Me-17), the structure of unit 1 can be ascribed to be an abietane diterpenoid [21–23]. The HMBC correlations (Fig. 1) from Me-20 (δH 1.40) to C-1 (δC 31.7), C-5 (δC 80.2), C-9 (δC 124.7), and C-10; from Me-18 (δH 1.32) and Me-19 (δH 1.02) to C-3 (δC 38.9), C-4, and C-5; from H-15 (δH 26.9) to C-12 (δC 181.8), C-13 (δC 141.3), and C-14 (δC 135.0); from H-14 (δH 6.55) to C-7 (δC 141.2), C-9, and C-12; and from H-6 (δH 5.42) to C-8 (δC 140.8), together with proton spin systems H-1/H-2/H-3 and H-6/H-7 obtained from the 1H–1H COSY spectrum (Fig. 1), established the structure of the unit 1.Fig. 1

Bottom Line: Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.

ABSTRACT

Two dimeric abietane diterpenoids, salviwardins A and B (1 and 2), and a seco-abietane diterpenoid salviwardin C (3), along with five known analogues (4-8), were isolated from the roots of Salvia wardii. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

No MeSH data available.


Related in: MedlinePlus