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Intraoperative Optical Coherence Tomography Using the RESCAN 700: Preliminary Results in Collagen Crosslinking.

Pahuja N, Shetty R, Jayadev C, Nuijts R, Hedge B, Arora V - Biomed Res Int (2015)

Bottom Line: The mean corneal hyperreflectance in the epi-on group was 12.97 ± 1.49 gray scale units (GSU) before instillation of riboflavin and 14.46 ± 2.09 GSU after AXCL (P = 0.019) while in the epi-off group it was 11.43 ± 2.68 GSU and 16.98 ± 8.49 GSU, respectively (P = 0.002).The average depth of the band of hyperreflectance in the epi-on group was 149.39 ± 15.63 microns and in the epi-off group it was 191.04 ± 32.18 microns.This novel in vivo, real time imaging study demonstrates riboflavin penetration during epi-on and epi-off ACXL.

View Article: PubMed Central - PubMed

Affiliation: Department of Cornea & Refractive Surgery, Narayana Nethralaya 121/C, Chord Road, 1st "R" Block, Rajajinagar, Bangalore, Karnataka 560 010, India.

ABSTRACT

Purpose: To compare the penetration of riboflavin using a microscope-integrated real time spectral domain optical coherence tomography (ZEISS OPMI LUMERA 700 and ZEISS RESCAN 700) in keratoconus patients undergoing accelerated collagen crosslinking (ACXL) between epithelium on (epi-on) and epithelium off (epi-off).

Methods: Intraoperative images were obtained during each of the procedures. Seven keratoconus patients underwent epi-on ACXL and four underwent epi-off ACXL. A software tool was developed using Microsoft.NET and Open Computer Vision (OpenCV) libraries for image analysis. Pre- and postprocedure images were analyzed for changes in the corneal hyperreflectance pattern as a measure of the depth of riboflavin penetration.

Results: The mean corneal hyperreflectance in the epi-on group was 12.97 ± 1.49 gray scale units (GSU) before instillation of riboflavin and 14.46 ± 2.09 GSU after AXCL (P = 0.019) while in the epi-off group it was 11.43 ± 2.68 GSU and 16.98 ± 8.49 GSU, respectively (P = 0.002). The average depth of the band of hyperreflectance in the epi-on group was 149.39 ± 15.63 microns and in the epi-off group it was 191.04 ± 32.18 microns.

Conclusion: This novel in vivo, real time imaging study demonstrates riboflavin penetration during epi-on and epi-off ACXL.

No MeSH data available.


Related in: MedlinePlus

Average depth of hyperreflectance band seen in patients after epi-off ACXL.
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fig6: Average depth of hyperreflectance band seen in patients after epi-off ACXL.

Mentions: The average depth of the hyperreflective band in the epi-on group was 149.39 ± 15.63 microns (Figure 5) and in the epi-off group was 191.04 ± 32.18 microns (Figure 6).


Intraoperative Optical Coherence Tomography Using the RESCAN 700: Preliminary Results in Collagen Crosslinking.

Pahuja N, Shetty R, Jayadev C, Nuijts R, Hedge B, Arora V - Biomed Res Int (2015)

Average depth of hyperreflectance band seen in patients after epi-off ACXL.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402560&req=5

fig6: Average depth of hyperreflectance band seen in patients after epi-off ACXL.
Mentions: The average depth of the hyperreflective band in the epi-on group was 149.39 ± 15.63 microns (Figure 5) and in the epi-off group was 191.04 ± 32.18 microns (Figure 6).

Bottom Line: The mean corneal hyperreflectance in the epi-on group was 12.97 ± 1.49 gray scale units (GSU) before instillation of riboflavin and 14.46 ± 2.09 GSU after AXCL (P = 0.019) while in the epi-off group it was 11.43 ± 2.68 GSU and 16.98 ± 8.49 GSU, respectively (P = 0.002).The average depth of the band of hyperreflectance in the epi-on group was 149.39 ± 15.63 microns and in the epi-off group it was 191.04 ± 32.18 microns.This novel in vivo, real time imaging study demonstrates riboflavin penetration during epi-on and epi-off ACXL.

View Article: PubMed Central - PubMed

Affiliation: Department of Cornea & Refractive Surgery, Narayana Nethralaya 121/C, Chord Road, 1st "R" Block, Rajajinagar, Bangalore, Karnataka 560 010, India.

ABSTRACT

Purpose: To compare the penetration of riboflavin using a microscope-integrated real time spectral domain optical coherence tomography (ZEISS OPMI LUMERA 700 and ZEISS RESCAN 700) in keratoconus patients undergoing accelerated collagen crosslinking (ACXL) between epithelium on (epi-on) and epithelium off (epi-off).

Methods: Intraoperative images were obtained during each of the procedures. Seven keratoconus patients underwent epi-on ACXL and four underwent epi-off ACXL. A software tool was developed using Microsoft.NET and Open Computer Vision (OpenCV) libraries for image analysis. Pre- and postprocedure images were analyzed for changes in the corneal hyperreflectance pattern as a measure of the depth of riboflavin penetration.

Results: The mean corneal hyperreflectance in the epi-on group was 12.97 ± 1.49 gray scale units (GSU) before instillation of riboflavin and 14.46 ± 2.09 GSU after AXCL (P = 0.019) while in the epi-off group it was 11.43 ± 2.68 GSU and 16.98 ± 8.49 GSU, respectively (P = 0.002). The average depth of the band of hyperreflectance in the epi-on group was 149.39 ± 15.63 microns and in the epi-off group it was 191.04 ± 32.18 microns.

Conclusion: This novel in vivo, real time imaging study demonstrates riboflavin penetration during epi-on and epi-off ACXL.

No MeSH data available.


Related in: MedlinePlus