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Reduced systemic levels of IL-10 are associated with the severity of obstructive sleep apnea and insulin resistance in morbidly obese humans.

Leon-Cabrera S, Arana-Lechuga Y, Esqueda-León E, Terán-Pérez G, Gonzalez-Chavez A, Escobedo G, Velázquez Moctezuma J - Mediators Inflamm. (2015)

Bottom Line: Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA.Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample.It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.

View Article: PubMed Central - PubMed

Affiliation: Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico.

ABSTRACT
Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance. Normal weight and MO subjects were subjected to overnight polysomnography in order to establish the severity of OSA, according to the apnea-hypopnea index (AHI). Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10). Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA. Besides being inversely associated with serum TNF-α and IL-12, decreased IL-10 levels were significantly related to increased AHI, hyperinsulinemia, and insulin resistance. Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample. It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.

No MeSH data available.


Related in: MedlinePlus

Circulating levels of IL-10 showed a negative significant association with (a) insulin levels and (b) HOMA-IR index. In contrast, AHI values were positively associated with (c) Insulin levels and (d) HOMA-IR index. Coefficient r and P values were calculated using Spearman's correlation model. The correlation level was considered significant when P < 0.05.
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fig2: Circulating levels of IL-10 showed a negative significant association with (a) insulin levels and (b) HOMA-IR index. In contrast, AHI values were positively associated with (c) Insulin levels and (d) HOMA-IR index. Coefficient r and P values were calculated using Spearman's correlation model. The correlation level was considered significant when P < 0.05.

Mentions: As was mentioned above, MO+OSA individuals exhibited a state of hyperinsulinemia and insulin resistance when compared with MO and control subjects (Table 1). Thus, to further analyze the association of IL-10 with these parameters, a correlation analysis was performed between IL-10 and both insulin and insulin resistance. Figure 2(a) shows a significant inverse correlation between IL-10 and blood insulin levels (r = −0.4; P = 0.007). As IL-10 levels decrease, insulin levels increase. A quite similar picture is observed in Figure 2(b). A significant inverse correlation between IL-10 levels and the insulin resistance index is shown (r = −0.40; P = 0.0002). As IL-10 decrease the HOMA-IR increases. To further analyze the relationship between insulin and the presence of AHI a correlation analysis was performed. As can be seen in Figures 2(c) and 2(d), there is a significant positive correlation between AHI and insulin (r = 0.48; P = 0.0003), as well as a positive correlation between AHI and HOMA-IR (r = 0.41; P = 0.004). The severity of apnea correlates with the increase of insulin and the increase of insulin resistance.


Reduced systemic levels of IL-10 are associated with the severity of obstructive sleep apnea and insulin resistance in morbidly obese humans.

Leon-Cabrera S, Arana-Lechuga Y, Esqueda-León E, Terán-Pérez G, Gonzalez-Chavez A, Escobedo G, Velázquez Moctezuma J - Mediators Inflamm. (2015)

Circulating levels of IL-10 showed a negative significant association with (a) insulin levels and (b) HOMA-IR index. In contrast, AHI values were positively associated with (c) Insulin levels and (d) HOMA-IR index. Coefficient r and P values were calculated using Spearman's correlation model. The correlation level was considered significant when P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4402489&req=5

fig2: Circulating levels of IL-10 showed a negative significant association with (a) insulin levels and (b) HOMA-IR index. In contrast, AHI values were positively associated with (c) Insulin levels and (d) HOMA-IR index. Coefficient r and P values were calculated using Spearman's correlation model. The correlation level was considered significant when P < 0.05.
Mentions: As was mentioned above, MO+OSA individuals exhibited a state of hyperinsulinemia and insulin resistance when compared with MO and control subjects (Table 1). Thus, to further analyze the association of IL-10 with these parameters, a correlation analysis was performed between IL-10 and both insulin and insulin resistance. Figure 2(a) shows a significant inverse correlation between IL-10 and blood insulin levels (r = −0.4; P = 0.007). As IL-10 levels decrease, insulin levels increase. A quite similar picture is observed in Figure 2(b). A significant inverse correlation between IL-10 levels and the insulin resistance index is shown (r = −0.40; P = 0.0002). As IL-10 decrease the HOMA-IR increases. To further analyze the relationship between insulin and the presence of AHI a correlation analysis was performed. As can be seen in Figures 2(c) and 2(d), there is a significant positive correlation between AHI and insulin (r = 0.48; P = 0.0003), as well as a positive correlation between AHI and HOMA-IR (r = 0.41; P = 0.004). The severity of apnea correlates with the increase of insulin and the increase of insulin resistance.

Bottom Line: Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA.Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample.It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.

View Article: PubMed Central - PubMed

Affiliation: Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico.

ABSTRACT
Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance. Normal weight and MO subjects were subjected to overnight polysomnography in order to establish the severity of OSA, according to the apnea-hypopnea index (AHI). Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10). Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA. Besides being inversely associated with serum TNF-α and IL-12, decreased IL-10 levels were significantly related to increased AHI, hyperinsulinemia, and insulin resistance. Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample. It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.

No MeSH data available.


Related in: MedlinePlus